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401.
One‐Pot Sequential Propargylation/Cycloisomerization: A Facile [4+2]‐Benzannulation Approach to Carbazoles 下载免费PDF全文
Dr. Chada Raji Reddy Reddi Rani Valleti Uredi Dilipkumar 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(7):2501-2506
A novel one‐pot [4+2]‐benzannulation approach to substituted carbazoles is accomplished by acid‐catalyzed C3‐propargylation of 2‐alkenyl/aryl indoles with 1‐aryl propargylic alcohols, followed by cycloisomerization. A variety of 2‐alkenylated indoles and 2‐aryl/heteroaryl indoles successfully participated in this tandem reaction with 1‐aryl/heteroaryl propargylic alcohols to provide diversely substituted and annulated carbazoles, as well as an aza[5]helicene. 相似文献
402.
Neha Atale Sharad Saxena J Grace Nirmala RT Narendhirakannan Sujata Mohanty Vibha Rani 《Applied biochemistry and biotechnology》2017,181(3):1140-1154
There exists a complex and multifactorial relationship between diabetes and cardiovascular disease. Hyperglycemia is an important factor imposing damage (glucose toxicity) on cardiac cell leading to diabetic cardiomyopathy. There are substantial clinical evidences on the adverse effects of conventional therapies in the prevention/treatment of diabetic cardiovascular complications. Currently, green-synthesized nanoparticles have emerged as a safe, efficient, and inexpensive alternative for therapeutic uses. The present study discloses the silver nanoparticle biosynthesizing capability and cardioprotective potential of Syzygium cumini seeds already reported to have antidiabetic properties. Newly generated silver nanoparticles S. cumini MSE silver nanoparticles (SmSNPs) were characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), zeta sizer, X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectroscopy. Using methanolic extract of S. cumini seeds, an average size of 40–100-nm nanoparticles with 43.02 nm and ?19.6 mV zeta potential were synthesized. The crystalline nature of SmSNPs was identified by using XRD. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) assays revealed the antioxidative potential to be 66.87 (±0.7) % and 86.07 (±0.92) % compared to 60.29 (±0.02) % and 85.67 (±1.27) % for S. cumini MSE. In vitro study on glucose-stressed H9C2 cardiac cells showed restoration in cell size, nuclear morphology, and lipid peroxide formation upon treatment of SmSNPs. Our findings concluded that S. cumini MSE SmSNPs significantly suppress the glucose-induced cardiac stress in vitro by maintaining the cellular integrity and reducing the oxidative damages therefore establishing its therapeutic potential in diabetic cardiomyopathy. 相似文献
403.
Vuradi Ravi Kumar Penumaka Nagababu G. Srinivas Mallepally Rajender Reddy M. Vinoda Rani Mudavath Ravi 《Journal of Coordination Chemistry》2017,70(22):3790-3809
An intercalative ligand, ppip (ppip = {2-(4-(piperidin-1-yl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline}), and its mononuclear Ru(II) polypyridyl complexes, [Ru(phen)2(ppip)]2+ (1) (phen=1,10-phenanthrolene), [Ru(bpy)2(ppip)]2+ (2) (bpy=2,2′-bipyridine) and [Ru(dmb)2(ppip)]2+ (3) (dmb=4,4′-dimethyl-2,2′-bipyridine), have been synthesized and characterized by elemental analysis and spectroscopic techniques such as UV–vis, IR, 1H, as well as 13C NMR and ESI-MS. The interaction of these complexes with DNA/BSA (bovine serum albumin) was investigated using absorption, emission spectroscopy, viscosity measurements and molecular docking studies. The docking study infers that the binding strength (Kb) of these complexes was in agreement with results from absorption and emission techniques. These studies reveal that these three Ru(II) polypyridyl complexes bind to DNA/BSA. The binding ability of these complexes in the presence of different ions and solvents were also reported. All complexes were effectively cleaving pBR322 DNA in different forms and follows order which is similar to absorption and emission studies. These complexes were effective exhibiting the antimicrobial activity against different microbes Bacillus subtilis, Escherichia coli and Staphylococcus aureus. 相似文献
404.
The dynamic response of a homogeneous, isotropic, generalized thermoelastic half-space with voids subjected to normal, tangential force and thermal source is investigated. The displacements, stresses, temperature distribution and change in volume fraction field so obtained in the physical domain are computed numerically and illustrated graphically. The numerical results of these quantities for magnesium crystal-like material are illustrated to depict the response of various sources in the Lord–Shulman (L–S) theory and Green–Lindsay (G–L) theory for an insulated boundary and temperature gradient boundary. Some particular cases have been deduced. 相似文献
405.
An efficient synthesis of 4-benzyl cinnolines from aryl phenylallylidene hydrazone is described. In this report aluminium chloride as a Lewis acid catalyst and toluene as a solvent are used for the synthesis. This method is expected to more advantageous than the other reported methods of synthesis of the cinnoline rings because of its low cost, better yield, and benign reaction conditions.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] 相似文献
406.
Mani Anusha Rani Veerappan JeyachandranMuthumani Muthu Subbiah SivakolunthuRaju Ranjith Kumar 《Tetrahedron letters》2014
A microwave-assisted chemoselective synthesis of novel pyrazolo[3,4-b]thieno[3,4-e]pyridines has been achieved via tandem Michael addition–cyclization–tautomerization–oxidative aromatization sequence of reactions. Compounds with ortho-substituted phenyl rings exhibited axial chirality due to restricted rotation around C–C single bond. 相似文献
407.
DABCO (1,4-diazabicyclo[2.2.2]octane) based Cu(I) metal organic framework (here after represented as Cu(I)-MOF) catalyzed Sonogashira cross-coupling reaction of iodobenzene and phenylacetylene was conducted smoothly to afford diphenylacetylene in excellent yield under N2 atmosphere. For comparative study, piperidine based Cu(I) clusters were also investigated. Among these catalysts, Cu(I)-MOF exhibited higher activity with good selectivity for the C–C cross-coupled product. Cu(I) catalysts investigated in this study exhibited similar activity in the C–C homo-coupling reaction of phenylacetylene in O2 atmosphere. Application of these catalysts was extended in the C–N coupling reactions between phenylboronic acid and aromatic/aliphatic/heterocyclic amines. Cu(I)-MOF can be readily recovered from the reaction mixture and reused for several cycles without loss in the catalytic activity. 相似文献
408.
Novel 4-aminoantipyrine based mixed ligand metal complexes with the Schiff bases ofL1(L1-4(furanylmethyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one and L2/ L3/ L4are 2-(2-chlorobenzylideneamino)phenol, 2-(3-chlorobenzylideneamino)phenol, 2-(4-chlorobenzylideneamino)phenol were synthesized. The structures of the mixed ligand complexes were established by analytical and spectral techniques. They were screened for in vitro antimicrobial activity against bacteria and fungi by disc diffusion method. The interaction of metal complexes with CT-DNA was investigated by UV–vis, cyclic voltammetry, viscosity and thermal denaturation studies.DNA interaction studies suggest that metal complex binds to calf thymus DNA (CT-DNA) through intercalation mode. Superoxide dismutase activity of these complexes has also been studied. The free ligands and their metal complexes have been tested for in vitro antioxidant activity by the reduction of 1,1-diphenyl-2-picryl hydrazyl (DPPH).The antioxidant activities of the complexes were studied and compared with the activity of ascorbic acid. Cu(II) complex showed superior antioxidant activity than other complexes. The solvatochromic behaviour of complexes was also performed in various solvents. 相似文献
409.
S. Ramanaiah P. Reddi Rani T. V. M. Sreekanth K. S. Reddy 《Journal of Macromolecular Science: Physics》2013,52(3):551-562
The specific retention volumes, , for adsorption of 21 solute probes on the solid surface of cellulose acetate butyrate (CAB) were determined in the temperature range 343.15 to 403.15 K by inverse gas chromatography (IGC). The weight fraction activity coefficients, , and Flory–Huggins interaction parameters, , were evaluated using . Both and values decreased with increase of temperature in all the solutes. Further, the values increased with increase of chain length in n-alkanes, but in the case of alcohols the trend was reversed. values were less than 0.5 in polar solutes and greater than 0.5 in 1-alkanes and alcohols. The Hansen solubility parameters (HSP) were calculated by relating with the cohesive energy of adsorption of the solutes on the surface of CAB. The adsorption model proposed by Snyder and Karger was used to determine the HSP for the CAB. The dispersive, , polar, , and hydrogen bonding components of HSP decreased with increase of temperature and the relative error associated with these parameters increased with increase of temperature. The characterization of the solid surface of CAB in terms of the three solubility parameter components was analyzed and is discussed. 相似文献
410.
We study dynamical wormhole solutions in the framework of $f(T)$ f ( T ) theory of gravity with anisotropic fluid. We assume a general dynamical spherically symmetric wormhole spacetime with specific form of the shape function and scale factor. The scale factor is taken in the power-law form in order to meet the accelerated expansion of the universe. We discuss the behavior of energy conditions for three particular choices of equation of state, i.e., radial and transverse pressures in linear form with energy density and traceless fluid. The energy conditions satisfy for certain time intervals in all cases. The radial coordinate does not play any role in graphs and the validity or violation of energy conditions depend upon the time coordinate only. The graphical behavior of the energy conditions become equivalent for radial and transverse pressures in all the three cases. 相似文献