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81.
Sodium bromide efficiently catalyses the regioselective cleavage of oxiranes with chlorotrimethylsilane to the corresponding O-silylated chlorohydrins in excellent yields. 相似文献
82.
S. D. Katore K. S. Adhav A. Y. Shaikh N. K. Sarkate 《International Journal of Theoretical Physics》2010,49(10):2358-2363
An exact higher dimensional LRS Bianchi type-I cosmological model is obtained in presence of thick domain walls in a scalar
tensor theory of gravitation proposed by Saez and Ballester (Phys. Lett. A113:467, 1985). Some physical and kinematical properties of the models are also discussed. 相似文献
83.
84.
In this Letter we investigate the propagation of coupled nonlinear Alfven-spin and helicon-spin waves in a composite medium having the properties of both magnetic and semiconducting materials. We arrive at the nonlinear evolution equations for these coupled waves using the reductive perturbation method for which we obtain soliton solutions. We also discuss the limiting cases for the two materials separately. 相似文献
85.
Varun A. Morde Mushtaque S. Shaikh Raghuvir R. S. Pissurlenkar Evans C. Coutinho 《Molecular diversity》2009,13(4):501-517
The search for new antimalarial agents is necessary as current drugs in the market become vulnerable due to the emergence
of resistance strains of Plasmodium falciparum (P. falciparum). The biosynthetic pathway for fatty acids has been recognized and validated as an important drug target in P.falciparum. One of the important enzymes in this pathway that has a determinant role in completing the cycles of chain elongation is
Enoyl-ACP reductase (ENR) also popularly known as FabI. In this paper we report the design, synthesis, and microbial evaluation of inhibitors of Plasmodium enoyl reductase (PfENR). The search for inhibitors involved a virtual screening of the iResearch database with docking simulations. One of the
hits was selected and modified to optimize its binding to PfENR; this resulted in the development of analogues of N-benzylidene-4-phenyl-1,3-thiazol-2-amine. The activity of these analogues was predicted from comparative molecular field
analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) models constructed from a dataset of 43 known
inhibitors of PfENR. The most promising molecules were synthesized and their structures characterized by spectroscopic techniques. The molecules
were screened for in vitro antimalarial activity by whole-cell assay method. Two molecules, viz. VRC-007 and VRC-009, were
found to be active at 4.67 and 7.01 μM concentrations, respectively. 相似文献
86.
Atta-Ur-Rahman Nasim S Baig I Ara Jahan I Sener B Orhan I Choudhary MI 《Chemical & pharmaceutical bulletin》2002,50(8):1100-1102
Four isoflavone glycosides were isolated from the rhizomes of Iris germanica. Compounds 1 and 2 are new, while compounds 3 and 4 are known isoflavone glycosides. These compounds were identified as iriskashmirianin 4'-O-beta-D-glucoside (1), nigricin 4'-O-beta-D-glucoside (2), irilone 4'-O-beta-D-glucoside (3) and iridin (4). Their structures were determined with the help of spectroscopic methods. 相似文献
87.
N-Cinnamoyl-L-proline can be used as a template on which beta-substituted phenylalanine and beta-phenylisoserine residues can be synthesized leading to tripeptide derivatives as structural analogues of HIV protease inhibitors. 相似文献
88.
The absorption spectra of7LiH have been photographed in the 3,500?2,900 Å region using the second order of a 3.4 M Ebert spectrograph. Observations comprise previously observedA 1 Σ +-X 1 Σ + transitions and several new vibrational bands of this system near the ionisation limit. Rotational and vibrational analysis of these bands (16≦V′≦20) have been carried out and the rotational constants for the upper states have been determined. 相似文献
89.
90.
A very rapid method for the separation of molybdenum(VI) from neutron irradiated uranium and its fission products is described. The procedure is based on the selective extraction of molybdenum(VI) by a 0.1M solution of 2-hexylpyridine in benzene from 4M HCl+0.04M KSCN. Decontamination factors were estimated to be >104 for the radionuclides of niobium, zirconium, ruthenium, lanthanum, cerium, promethium, yttrium, strontium and barium. 相似文献