Effect of ring substitution on synthesis of benzimidazolium salts and their silver(I) complexes: characterization,electrochemical studies and evaluation of anticancer potential

Transition Metal Chemistry - A series of bidendate 5,6-dimethyl benzimidazolium-based N-heterocyclic carbene (NHC) proligands and their silver complexes were synthesized. The synthetic approaches...     

Synthesis of new 3'-, 5-, and N(4)-modified 2'-O-methylcytidine libraries on solid support

A versatile solid phase combinatorial approach was developed and utilized for the rapid synthesis of new 2'-O-methylcytidine nucleoside libraries 1-7 containing 672 compounds with 3'-deoxy-3'-C-methyl, 3'-deoxy-3'-C-hydroxymethyl, and 5-alkyl/alkynyl modifications. The modified uridine scaffolds 8-10, 23-25, and 31 were loaded onto the 4-methoxytrityl chloride (MMT-Cl) polystyrene resin through the hydroxyl groups at the 5'-position as well as on the substituents at the 3'- and 5-positions. The scaffolds loaded on the resin were orthogonally protected by MMT group on the resin itself and TBDMS or acetyl protecting groups. The 4-position of the uridine derivatives was activated by 2,4,6-triisopropyl benzene sulfonyl chloride for further derivatization. The resins 14-16, 28-30, and 32 loaded with the corresponding activated scaffolds were reacted with the selected and validated amino building blocks in the 96 well format on the semiautomated synthesizer. The high-quality 2'-O-methylcytidine libraries 1-7 were thus generated and characterized by liquid chromatography-mass spectrometry (LC-MS) analysis with 63-99% successful rates.     

Preparation,characterization, and applications of a novel solid-phase microextraction fiber by sol-gel technology on the surface of stainless steel wire for determination of poly cyclic aromatic hydrocarbons in aquatic environmental samples

A novel solid-phase microextraction(SPME) fiber was prepared using sol–gel technology with ethoxylated nonylphenol as a fiber coating material. The fiber was employed to develop a headspace SPME–GC–MS method suitable for quantification of 13 polycyclic aromatic hydrocarbons (PAHs) in water samples. Surface characteristics of the fibers were inspected by energy dispersive X-ray (EDX) spectroscopy as well as by scanning electron microscopy (SEM). The SEM measurements showed the presence of highly porous nano-sized particles in the coating. Important parameters affecting the extraction efficiency such as extraction temperature and time, desorption conditions as well as ionic strength have been evaluated and optimized. In the next step, the validation of the new method have been performed, finding it to be specific in the trace analysis of PAHs, with the limit of detection (LOD) ranging from 0.01 to 0.5 μg L⁻¹ and the linear range from the respective LOD to 200 μg L⁻¹with RSD amounting to less than 8%. The thermal stability of the fibers was investigated as well and they were found to be durable at 280 °C for 345 min. Furthermore, the proposed method was successfully applied for quantification of PAHs in real water samples.     

Comportements compares des sols et des roches

Résumé Les sols et les roches sont des corps dont le comportement rhéologique est régi par les liaisons de contact entre les éléments qui les constituent. On peut schématiser ces structures en disant que dans les sols, les contacts sont ponctuels entre les grains alors qu'ils ont lieu sur les surfaces que forment les fissures entre les blocs pour les massifs rocheux. Au cours des déformations qui précèdent la rupture, des glissements se produisent le long de surfaces irrégulières et les mouvements sont accompagnés d'une variation de volume, qui est positive pour les roches et les sables denses, et négative pour les sables lâches et la plupart des argiles. Les roches présentent un effet d'échelle: les caractéristiques mécaniques de la rupture sont des fonctions décroissantes de la dimension de la zone soumise aux contraintes et ceci est lié à l'hétérogénéité de la fissuration. Cet effet n'apparaît pas dans les sols, mais dans un champ de contraintes hétérogène, comme celui qui existe sous un poinçon, un phénomène analogue se produit pour les sables denses. On peut l'expliquer par l'hétérogénéité introduite dans le milieu par la création d'une ligne de glissement isolée.

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Summary Rheological behaviour of soils and rocks is determined by contact forces between constitutive elements. For soils, the contacts are punctual. For rocks they occur along the surfaces of cracks or joints. During the deformation before the failure, sliding movements occur along irregularly shaped surfaces with a volume change, which is positive for rocks and dense sands, negative for loose sands and most of clays. Size effect in rocks is due to cracks heterogeneity: mechanical characteristics at failure decrease with increasing size of specimens. This effect does not exist in soils, but in a heterogeneous stress field a similar phenomenon appears in dense sands. It is connected with the heterogeneity induced by the creation of an isolated slip line.

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Avec 9 figures     

An experimental investigation of heat transfer to pulsating pipe air flow with different amplitudes

Heat transfer characteristics to both laminar and turbulent pulsating pipe flows under different conditions of Reynolds number, pulsation frequency, pulsator location and tube diameter were experimentally investigated. The tube wall of uniform heat flux condition was considered for both cases. Reynolds number varied from 750 to 12,320 while the frequency of pulsation ranged from 1 to 10 Hz. With locating the pulsator upstream of the inlet of the test section tube, results showed an increase in heat transfer rate due to pulsation by as much as 30% with flow Reynolds number of 1,643 and pulsation frequency of 1 Hz, depending on the upstream location of the pulsator valve. Closer the valve to the tested section inlet, the better improvement in the heat transfer coefficient is achieved. Upon comparing the heat transfer results of the upstream and the downstream pulsation, at Reynolds number of 1,366 and 1,643, low values of the relative mean Nusselt number were obtained with the upstream pulsation. Comparing the heat transfer results of the two studied test sections tubes for Reynolds number range from 8,000 to 12,000 and pulsation frequency range from 1.0 to 10 Hz showed that more improvement in heat transfer rate was observed with a larger tube diameter. For Reynolds number ranging from 8,000 to 12,000 and pulsation frequency of 10 Hz, an improvement in the relative mean Nusselt number of about 50% was obtained at Reynolds number of 8,000 for the large test section diameter of 50 mm. While, for the small test section diameter of 15 mm, at same conditions of Reynolds number and frequency, a reduction in the relative mean Nusselt number of up to 10% was obtained.     

Independent measurement of the total active 8B solar neutrino flux using an array of 3He proportional counters at the Sudbury Neutrino Observatory

The Sudbury Neutrino Observatory (SNO) used an array of 3He proportional counters to measure the rate of neutral-current interactions in heavy water and precisely determined the total active (nu_x) 8B solar neutrino flux. This technique is independent of previous methods employed by SNO. The total flux is found to be 5.54_-0.31;+0.33(stat)-0.34+0.36(syst)x10(6) cm(-2) s(-1), in agreement with previous measurements and standard solar models. A global analysis of solar and reactor neutrino results yields Deltam2=7.59_-0.21;+0.19x10(-5) eV2 and theta=34.4_-1.2;+1.3 degrees. The uncertainty on the mixing angle has been reduced from SNO's previous results.     

Impact of laser produced X-rays on the surface of gold

In the paper an attempt has been made to use the laser-induced plasma as an X-ray source for the growth of nanostructures on the surface of gold. For this purpose, an Nd:YAG laser operated at second harmonics (λ = 532 nm, E = 400 mJ) is used to produce plasma from analytical grade 5N pure Al, Cu and W targets. An analytical grade (5N pure) gold substrate was irradiated by X-rays generated from Al, Cu and W plasma under the vacuum ∼10⁻⁴ Torr. The surface was analyzed by two techniques, XRD and AFM. The aberrations in the XRD peaks show that there are significant structural changes in the exposed gold, in terms of decreased reflection intensities, increased dislocation line density, changes in the d-spacing and disturbance in the periodicity of the planes. AFM used to explore the topography of the irradiated gold reveals that regardless of the source, nm sized hillocks have been produced on the gold surface. The roughness of the surface has increased due to the growth of these hillocks.     

First-Order Intertwining Operators with Position Dependent Mass and <Emphasis Type="Italic">η</Emphasis>-Weak-Pseudo-Hermiticity Generators

A Hermitian and an anti-Hermitian first-order intertwining operators are introduced and a class of η-weak-pseudo-Hermitian position-dependent mass (PDM) Hamiltonians are constructed. A corresponding reference-target η-weak-pseudo-Hermitian PDM—Hamiltonians’ map is suggested. Some η-weak-pseudo-Hermitian -symmetric Scarf II and periodic-type models are used as illustrative examples. Energy-levels crossing and flown-away states phenomena are reported for the resulting Scarf II spectrum. Some of the corresponding η-weak-pseudo-Hermitian Scarf II- and periodic-type-isospectral models ( -symmetric and non- -symmetric) are given as products of the reference-target map.     

Improvement of thermal and spectroscopic behavior of Er<Superscript>3+</Superscript>/Ce<Superscript>3+</Superscript> co-doped tellurite glass for lasing materials

Tellurite glasses (TeO₂–ZnO–Nb₂O₅) mono-doped Er³⁺ and co-doped Er³⁺/Ce³⁺ have been prepared using the melt-quenching technique. To evaluate the effect of Ce³⁺ on the structural, thermal stability of glass hosts and fluorescence properties of Er³⁺, X-ray diffraction patterns, Ftir spectra, differential scanning calorimeter curves, absorption spectra, fluorescence emission spectra, fluorescence lifetimes, up-conversion emission spectra of glass samples were measured and investigated. Using Judd–Ofelt theory, we calculated intensity parameters (Ω₂, Ω₄ and Ω₆), spontaneous emission probabilities, the radiative lifetime, luminescence branching factors and the quantum yield of luminescence for ⁴I_13/2 → ⁴I_15/2 transition. The co-doping with Ce³⁺ was effective on the suppression of up-conversion emission of Er³⁺ owing to the phonon-assisted energy transfer: Er³⁺:⁴I_11/2 + Ce³⁺:²F_5/2 → Er³⁺:⁴I_13/2 + Ce³⁺:²F_7/2 which contributed the effective enhancement of 1.53 µm fluorescence emission. The change in optical properties with the addition of Ce³⁺ ions have been discussed and compared with other glasses. Using the Mc Cumber method for the ⁴I_13/2 → ⁴I_15/2 transition, absorption cross-section, calculated emission cross-section, and gain cross-section values support that TZNEr1Ce1 glass is a potential material for developing broad-band and high-gain erbium-doped fiber amplifiers applied for 1.53 µm.