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131.
Robabeh Baharfar Mohammad Javad Taghizadeh Majid Ahmadian Seyed Meysam Baghbanian 《中国化学快报》2010,21(2):175-178
<正>The addition of 2,4-dihydroxyaceto(and benzo)phenone to propiolic ester is catalyzed by triphenylphosphine or tert-butyl isocyanide to form O-vinyl aryl derivatives in fairly good yields. 相似文献
132.
Seyed Jalal Hosseinimehr Amirhossein Ahmadi Reza Taghvai 《Journal of Radioanalytical and Nuclear Chemistry》2010,284(3):563-566
Free radicals and oxidative stress are the primary causes of several chronic diseases such as cancer and heart disease. Quercetin
is a natural compound with potent antioxidant activity. We have prepared and evaluated technetium-99m (99mTc)-labeled quercetin as a potential radical scavenging radiotracer. A 99mTc-quercetin complex was prepared using quercetin, SnCl2 and Na99mTcO4 in a buffered solution over 30 min. The participation coefficient was measured in octanol and queues solutions. The stability
was determined in phosphate buffered saline and serum. The biodistribution in normal mice was evaluated at 0.5, 2, 6 and 24 h
post-injection. The radiochemical purity (>99%) was determined by thin layer chromatography (TLC) in normal saline solution
as the mobile phase. It has a log P of 0.204. It was mainly cleared by the kidneys and showed negligible brain uptake at four time points measured post-injection.
The pharmacological properties of quercetin, mainly its free radical scavenging, may potentially cat as a radiopharmaceutical
agent for radical-targeted imaging of tissue with high levels of reactive oxygen species. 相似文献
133.
A mild and efficient method for the synthesis of 1H-chromeno[2,3-d]pyrimidine-5-carboxamide derivatives via a one-pot, three-component reaction of an isocyanide, barbituric acid, and a salicylaldehyde in the presence of acetic acid in ethanol/water mixture at 75 °C is reported. This high atom economy reaction led to the construction of one benzopyran ring, and one amide group in a single synthetic step. 相似文献
134.
Background
Hemodialysis patient are at high risk for hepatitis B virus (HBV) infection. 相似文献135.
Nanomolar Determination of Methyldopa in the Presence of Large Amounts of Hydrochlorothiazide Using a Carbon Paste Electrode Modified with Graphene Oxide Nanosheets and 3‐(4′‐Amino‐3′‐hydroxy‐biphenyl‐4‐yl)‐acrylic Acid 下载免费PDF全文
A novel electrochemical sensor for sensitive detection of methyldopa at physiological pH was developed by the bulk modification of carbon paste electrode (CPE) with graphene oxide nanosheets and 3‐(4′‐amino‐3′‐hydroxy‐biphenyl‐4‐yl)‐acrylic acid (3,′AA). Applying square wave voltammetry (SWV), in phosphate buffer solution (PBS) of pH 7.0, the oxidation current increased linearly with two concentration intervals of methyldopa, one is 1.0×10?8–1.0×10?6 M and the other is 1.0×10?6–4.5×10?5 M. The detection limit (3σ) obtained by SWV was 9.0 nM. The modified electrode was successfully applied for simultaneous determination of methyldopa and hydrochlorothiazide. Finally, the proposed method was applied to the determination of methyldopa and hydrochlorothiazide in some real samples. 相似文献
136.
137.
Masoumeh Zakeri Mohamed Mahmoud Nasef Tina Kargaran Arshad Ahmad Ebrahim Abouzari-Lotf Jahanbakhsh Asadi 《Research on Chemical Intermediates》2017,43(2):717-728
Optimization of a green approach to the synthesis of pyrano[2,3-c]pyrazoles based on the one-pot, four-component condensation via a domino Knoevenagel/Michael/cyclization sequence was investigated. This method involved the evaluation of the activity of several ionic liquids (ILs) in various solvents. This one-pot, four-component reaction revealed simplicity, higher yield and lower toxicity advantages over a corresponding three-component method. The effect of reaction parameters including the type and amount of catalyst, type of solvent, reaction temperature and time were studied with respect to yield of pyrano[2,3-c]pyrazoles. Catalyst recyclability and time-saving aspects of the reaction suggest that this method presents real alternatives over conventional reaction protocols. 相似文献
138.
Esmail Vessally Akram Hosseinian Ladan Edjlali Ebrahim Ghorbani-Kalhor Rahim Hosseinzadeh-Khanmiri 《Journal of the Iranian Chemical Society》2017,14(11):2339-2353
Indole derivatives are an important class of heterocycle found in a large number of natural products and synthetic pharmaceuticals. Given the low cost and easy availability of N-propargyl anilines, synthesis of indole cores from these versatile structural motifs has attracted a lot of attention in the past decade. In this review, we summarize the most representative and interesting reports on this rapidly advancing area, with special emphasis on mechanistic aspects of the reactions. 相似文献
139.
Zahra Shokri Behzad Zeynizadeh Seyed Ali Hosseini Behrooz Azizi 《Journal of the Iranian Chemical Society》2017,14(1):101-109
Magnetically separable nano core–shell Fe3O4@Cu(OH)x with 22 % Cu content was prepared by the addition of sodium hydroxide to a mixture of CuCl2·2H2O and nano Fe3O4 in water. Characterization of the impregnated copper hydroxide was carried out by X-ray fluorescence (XRF), X-ray diffraction (XRD) atomic absorption spectroscopy (AAS), scanning electron microscopy (SEM), value stream mapping (VSM) and Brunauer–Emmett–Teller (BET) analysis. The core–shell nanocatalyst exhibited the excellent catalytic activity toward reduction of various nitro compounds to the corresponding amines with NaBH4. All reactions were carried out in H2O (55–60 °C) within 3–15 min to afford amines in high to excellent yields. Reusability of core–shell Cu(OH)x catalyst was examined 9 times without significant loss of its catalytic activity. 相似文献
140.
The synthesis of coumarins by hydroxyalkylation of phenols with ethyl acetoacetate (via Pechmann reaction) is attempted using magnetically separable and reusable CuFe2O4 nanoparticles in water.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications ® for the following free supplemental resource(s): Full experimental and spectral details.] 相似文献