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991.
Min‐Jung Song Jong‐Hoon Kim Seung‐Koo Lee Dae‐Soon Lim Sung Woo Hwang Dongmok Whang 《Electroanalysis》2011,23(10):2408-2414
An electrochemical biosensor was developed using Pt‐nanoparticles (Pt‐NPs) dispersed graphene based on a boron‐doped diamond thin film electrode. To compare its performances with those of other biosensors, glucose was used as a target analyte. This biosensor exhibited a wide linear range, a low detection limit and a higher sensitivity compared to other amperometric biosensors using graphene‐based electrodes. In addition, the biosensor promotes a direct electron transfer between the redox enzymes and the electrode surface and detects low concentration analytes. The excellent performance of the biosensor is attributed to the synergistic effect of the Pt‐NPs, graphene sheet and the BDD thin film. Therefore, it can be a promising application for electrochemical detection of analytes. 相似文献
992.
Woo Gi Lee Jin Suk Lee Chul Seung Shin Soon Chul Park Ho Nam Chang Yong Keun Chang 《Applied biochemistry and biotechnology》1999,78(1-3):547-559
Ethanol production from concentrated oak wood hydrolysate was carried out to obtain a high ethanol concentration and a high
ethanol yield. The effect of added inhibitory compounds, which are typically produced in the pretreatment step of steam-explosion
on ethanol fermentation, was also examined. p-Hydroxybenzoic aldehyde, a lignin-degradation product, was the most inhibitory compound tested in this study. Compounds with
additional methyl groups had reduced toxicity and the aromatic acids were less toxic than the corresponding aldehydes. The
lignin-degradation products were more inhibitory than the sugar-derived products, such as furfural and 5-hydroxymethylfurfural
(HMF). Adaptation of yeast cells to the wood hydrolysate and detoxification methods, such as using charcoal and overlime,
had some beneficial effects on ethanol production using the concentrated wood hydrolysate. After treatment with charcoal and
low-temperature sterilization, the yeast cells could utilize the concentrated wood hydrolysate with 170 as well as 140 g/L
glucose, and produce 69.9 and 74.2 g/L ethanol, respectively, with a yield of 0.46–0.48 g ethanol/g glucose. In contrast,
the cells could not completely utilize untreated wood hydrolysate with 100 g/L glucose. Low-temperature sterilization, with
or without charcoal treatment, was very effective for ethanol production when highly concentrated wood hydrolysates were used.
Low-temperature sterilization has advantages over traditional detoxification methods, such as using overlime, ion exchange,
and charcoal, because of the reduction in the total cost of ethanol production. 相似文献
993.
994.
995.
A long alkylsilyl group was attached to a thiophene ring system to overcome the instability of 2,5‐bis(halomethyl)thiophene monomers, by imparting steric hindrance and electronic delocalization. The resulting stable monomer could be used directly to prepare low‐band‐gap poly(thienylenevinylene) (1.57 eV) through heteroaromatic dehydrohalogenation polymerization.
996.
Structure and surface properties of polymers confined between two surfaces are studied in the presence of diluent by using an off‐lattice Monte Carlo method. When the diluent–chain interaction is weak, the density of diluent beads near the surface increases sharply with increasing the diluent–surface interaction while the chain bead density near the surface decreases gradually. The total bead density near the surface increases with increasing the diluent–surface interaction until it exceeds the total bulk density. This is mainly due to a large increase in the diluent bead density near the surface. Because of the increase of diluent at the surface, chains near the surface change their conformation, i.e., long tails become abundant while short trains and loops are relatively depleted. On the other hand, when the diluent–chain interaction becomes strong, the total bead density near the surface increases slightly, but it exceeds the total bulk density only when the diluent–surface interaction is strong enough, because the diluents approaching the surface induce chain beads to move to the surface due to strong interaction between the chain and diluent. 相似文献
997.
998.
999.
Su Bin Kim Yoon Sin Oh Kwang Joon Kim Sung Woo Cho Seung Ki Park Dong Jae Baek Eun-Young Park 《Molecules (Basel, Switzerland)》2022,27(10)
Sphingosine kinase (SK) is involved in the growth of cells, including cancer cells. However, which of its two isotypes—SK1 and SK2—is more favorable for cancer growth remains unclear. Although PF-543 strongly and selectively inhibits SK1, its anticancer effect is not high, and the underlying reason remains difficult to explain. We previously determined that the tail group of PF-543 is responsible for its low metabolic stability (MS). In this study, compounds containing aromatic or aliphatic tails in the triazole group were synthesized, and changes in the SK-inhibitory effect and anticancer activity of PF-543 were assessed using pancreatic cancer cells. The compounds with aliphatic tails showed high inhibitory effects on pancreatic cancer cells but slightly lower selectivity for SK1. A compound with an introduced aliphatic tail activated protein phosphatase 2A (PP2A), showing an effect similar to that of FTY720. Molecular docking analysis revealed that the PP2A-binding form of this newly synthesized compound was different from that noted in the case of FTY720. This compound also improved the MS of PF-543. These results indicate that the tail structure of PF-543 influences MS. 相似文献
1000.
Chonglu Li Yuling Xu Le Tu Minhyeok Choi Yifan Fan Xiaoqiang Chen Jonathan L. Sessler Jong Seung Kim Yao Sun 《Chemical science》2022,13(22):6541
Ruthenium complexes are emerging as potential complements to platinum drugs. They also show promise as photo-diagnostic and therapeutic agents. However, most ruthenium species studied to date as potential drugs are characterized by short excitation/emission wavelengths. This limits their applicability for deep-tissue fluorescence imaging and light-based therapeutic treatments. Here, we report a Ru(ii) metallacycle (Ru1100) that emits at ≥1000 nm. This system possesses excellent deep-tissue penetration capability (∼7 mm) and displays good chemo-phototherapeutic performance. In vitro studies revealed that Ru1100 benefits from good cellular uptake and produces a strong anticancer response against several cancer cell lines, including a cisplatin-resistant A549 cell line (IC50 = 1.6 μM vs. 51.4 μM for cisplatin). On the basis of in vitro studies, it is concluded that Ru1100 exerts its anticancer action by regulating cell cycle progression and triggering cancer cell apoptosis. In vivo studies involving the use of a nanoparticle formulation served to confirm that Ru1100 allows for high-performance NIR-II fluorescence imaging-guided precise chemo-phototherapy in the case of A549 tumour mouse xenografts with no obvious side effects. This work thus provides a paradigm for the development of long-wavelength emissive supramolecular theranostic agents based on ruthenium.Along-wavelength emissive Ru(ii) metallacycle chemo-phototheranostic was prepared via self-assembly that exhibits excellent photostability, deep-tissue penetration capability, and promising chemo-phototherapeutic performance in vitro and in vivo. 相似文献