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101.
Two novel calix[4]arene receptors containing ferrocene units in cone (L1) and 1,3-alternate (L2) conformations have been synthesized from 25,27-dihydroxy-26,28-bis[(3-aminopropyl)oxy]calix[4]arene 4 or 25,26,27,28-tetra[(3-aminopropyl)oxy]calix[4]arene 6 and ferrocenecarboxaldehyde via condensation, respectively. Their structures have been characterized by 1H, 13C, APT, COSY NMR, FTIR, HSMR, and UV–vis spectral data. The electrochemical behavior of L1 and L2 has been investigated in the presence of F?, Cl?, Br?, H2PO4?, CH3COO? anions. Electrochemical studies show that these receptors electrochemically recognize CH3COO?, H2PO4?, and Cl?, anions. Using an UV–vis study, the selectivity to these anions in DMSO solution was confirmed. 相似文献
102.
Serkan Erdemir Mustafa Yilmaz 《Journal of inclusion phenomena and macrocyclic chemistry》2012,73(1-4):141-150
Two novel chiral di- and tri-amide derivatives of p-tert-butylcalix[4]arene were synthesized by (R)-(+)-1-Phenylethylamine via convenient reactions and then immobilized on aminopropyl functionalized silica particles. The prepared chiral calix[4]arenes and their silica polymers (Calix-SP1 and Calix-SP2) were characterized using 1H NMR, 13C NMR, FT-IR, and thermal and elemental analysis techniques. 相似文献
103.
Serkan Erdemir Ozlem Sahin Arzu Uyanik Mustafa Yilmaz 《Journal of inclusion phenomena and macrocyclic chemistry》2009,64(3-4):273-282
Synthesis of the glutaraldehyde derivatives calix[n]arene (n = 4,6,8) (Calix[n]-GA) and using as cross-linkers for immobilization of Candida rugosa lipase (CRL) have been discussed in this paper. The amino functional calix[n]arene derivatives (Calix[n]-NH 2) were synthesized via reduction of dinitrile, hexanitrile and octanitrile derivatives of calix[n]arenes. These amino functional calix[n]arene derivatives (Calix[n]-NH 2) were converted to their aldehyde derivativatives with glutaraldehyde. The calix[n]arene derivatives were used in lipase immobilization in order to see the role of calix[n]arene binding site on the lipase activitiy and stability. The activity recovery of calix[n]arene-supported lipases (Calix[n]-CRL) based on the Calix[4]-CRL, Calix[6]-CRL and Calix[8]-CRL reaches to 53.5, 66.1 and 76.4%, respectively. 相似文献
104.
Sertel S Plinkert PK Efferth T 《Combinatorial chemistry & high throughput screening》2010,13(10):849-854
The epidermal growth factor receptor (EGFR) has become an important molecular target in cancer therapy. Various small molecules and therapeutic antibodies targeting EGFR family members have been developed during recent years and are established in clinical oncology. However, increasing clinical application of EGFR tyrosine kinase inhibitors has resulted in the development of resistance to EGFR-targeting drugs due to the selection of EGFR-mutated variants. This phenomenon forced the search for novel EGFR inhibitors with activity towards EGFR-mutant tumors. This review describes recent achievements in natural products derived from medicinal plants as novel EGFR inhibitors. 相似文献
105.
In this paper, the interaction of rutin (Rt) with rifampicin (RIF) has been investigated using voltammetric and spectroscopic
techniques. With the addition of RIF into the Rt solution, both the reduction and oxidation currents of rutin decrease with
few changes in the peak potentials and no new peaks appeared. The binding of Rt with RIF forms a kind of supramolecular complex
Rt-RIF, which is electrochemically non-active. The experimental data showed that the formation of supramolecular complex is
due to the electrostatic attraction of Rt with RIF. The binding reaction resulted in the decrease of the concentration of
free Rt in the solution, and the decrease of the cathodic peak current of Rt. The stoichiometry of the Rt-RIF biocomplex was
determinated to be 1: 1 by means of voltammetric data. The effect of pH on the binding reaction has been also studied. Based
on the peak current values of Rt in the presence and absence of RIF, the binding constants of Rt-RIF at pHs 4, 7 and 9 were
calculated as 0.72 × 104 M−1, 1.28 × 104 M−1 and 0.19 × 104 M−1, respectively. The experimental results indicate that there is a strength interaction between Rt and RIF in neutral pH. This
binding reaction was supported by UV-Vis. and IR spectroscopy techniques. 相似文献
106.
Bahram?RangipourEmail author Serkan?Sütlü 《Communications in Mathematical Physics》2012,311(2):491-511
To any locally finite representation of a given double crossed sum (product) Lie algebra (group), we associate a stable anti
Yetter-Drinfeld (SAYD) module over the bicrossed product Hopf algebra which arises from the semidualization procedure. We
prove a van Est isomorphism between the relative Lie algebra cohomology of the total Lie algebra and the Hopf cyclic cohomology
of the corresponding Hopf algebra with coefficients in the associated SAYD module. 相似文献
107.
108.
Abstract
We propose a method of fluid simulation where boundary conditions are designed in such a way that fluid flow through porous media, pipes, and chokes can be realistically simulated. Such flows are known to be low Reynolds number incompressible flows and occur in many real life situations. To obtain a high quality fluid surface, we include a scalar value in isofunction. The scalar value indicates the relative position of each particle with respect to the fluid surface. 相似文献109.
Serkan Eryılmaz 《Statistics & probability letters》2010,80(9-10):834-839
In this paper we study stress–strength reliability for a general coherent system. The exact expression as well as bounds and approximations for system reliability are presented. We also illustrate the estimation procedure for exponential stress–strength distributions. 相似文献
110.
Ulviye Acar Çevik Derya Osmaniye Begüm N. Sağlik Serkan Levent Betül K. Çavuşoğlu Abdullah B. Karaduman Ümide D. Özkay Yusuf Özkay Zafer A. Kaplancikli Gülhan Turan 《Journal of heterocyclic chemistry》2020,57(5):2225-2233
Monoamine oxidases (MAO) are enzymes that catalyze the oxidative deamination of monoamines such as dopamine, noradrenaline, adrenaline, and serotonin. Recent studies have shown that numerous benzothiazole derivatives exhibit hMAO inhibitory activity in the micromolar concentration range. In this study, a novel series of benzothiazole-thiadiazole (5a-5l ) was synthesized and characterized their chemical structures by 1H-NMR, 13C-NMR, and Mass spectroscopy. These compounds were evaluated as inhibitors for types A and B MAO enzymes. Compounds 5f and 5l were the most active derivatives in the series with an IC50 values of 0.107 ± 0.003 and 0.128 ± 0.004, respectively. Furthermore, cytotoxicity of compounds 5f and 5l were investigated and found as non-cytotoxic. 相似文献