Synthesis and chiroptical properties of two new planar-chiral macrocycles

Could simple intraannular-arm macrocyclic systems exist in enantiopure stable forms? The effective synthesis of two representative compounds of such a class, their resolution into enantiomers, and experiments justifying their stability toward racemization are presented.     

Combined supercritical-fluid chromatography/mass spectrometry in the analysis of diuron in plasma using on-line phase-system switching

On-line sample pretreatment by means of the phase-system switching approach is an interesting technique for the analysis of aqueous samples, e.g., plasma, by means of supercritical-fluid chromatography. In order to analyse plasma samples the following analytical procedure is used. The plasma sample is injected on to a short precolumn, which is washed with water and subsequently dried with nitrogen. Next, the solutes are desorbed with the supercritical mobile phase, analysed with packed-column supercritical-fluid chromatography and detected with either a UV detector or a mass spectrometer, equipped with a moving-belt interface. The herbicide diuron is selected as a test compound to study the feasibility of this approach. Using a selective detector the procedure is sufficiently sensitive to detect diuron in plasma, but not appropriate to detect the diuron metabolites in a post-mortem plasma sample. These have been identified with liquid chromatography/mass spectrometry. The detection limit of diuron in plasma using the procedure described is about 30 ng/mL.     

Collective flow model for the pion transverse momentum spectra from relativistic nuclear collisions at CERN

The transverse momentum spectra for pions observed by WA80 and NA35 collaborations are analysed within a fireball model with collective isentropic expansion and a realistic freeze-out criterion. By varing the initial state of the fireball, an excellent fit to the data is achieved for the whole measured range ofP _T . Slight differences in the data for the spectral slopes from central and pheripheral collisions originate in our model from the difference in the size of the fireball and in the number of participating nucleons in central and peripheral collisions. Using additional information from two-pion correlations, we can extrapolate our model back from the freeze-out point (determined from the spectra) to the initial state; we find that an initial energy density of 1.5–2GGeV/fm³ is sufficient to explain the data from central O+Au collisions at 200A GeV.     

Size complementarity in anion recognition by neutral macrocyclic tetraamides

Comparison of the anion binding properties of a series of uncharged macrocyclic tetraamides reveal significant effects of the receptor's size on the strength of its anion complexes. This study allowed for estimation of the optimal size of a macroring for complexation of common anions.     

Effect of superfluidity on the structure of the inner crust of neutron stars

A self-consistent, completely quantum calculation of the structure of the inner crust of neutron stars is carried out in the Wigner-Seitz approximation with a realistic phenomenological nuclear energy functional, where pair correlations of neutrons and protons are included in the explicit form. It has been shown that the superfluidity of neutrons and protons affects the structure of the ground state of the crust.     

Reactions of massive nuclei for the synthesis of heavy and superheavy nuclei

We study the effect of the entrance channel and the shell structure of reacting massive nuclei on the fusion mechanism and the formation of evaporation residues of heavy and superheavy nuclei. In the framework of the combined dinuclear system concept and advanced statistical model, we analyze the reactions ³²S+¹⁸²W, ⁴⁸Ti+¹⁶⁶Er and ⁶⁰Ni+¹⁵⁴Sm leading to ²¹⁴Th^*, and the reactions ⁴⁸Ca+²⁴⁸Cm and the ⁴⁸Ca+²⁴⁹Cf leading to the ²⁹⁶116 and ²⁹⁷118 compound nuclei, respectively.     

Recent advances in the analysis of steroid hormones and related drugs.

The development during the last 15 years and the state-of-the-art in the analysis of bulk steroid hormone drugs and hormone-like structures and pharmaceutical formulations made thereof are summarized. Other steroids (sterols, bile acids, cardiac glycosides, vitamins D) as well as biological-clinical aspects and pharmacokinetic and metabolic studies are excluded from this review. The state-of-the-art is summarized based on comparisons of monographs in the latest editions of the European Pharmacopoeia, United States Pharmacopoeia and the Japanese Pharmacopoeia. This is followed by sections dealing with new developments in the methodology for the fields of spectroscopic and spectrophotometric, chromatographic, electrophoretic and hyphenated techniques as well electroanalytical methods. The review is terminated by two problem-oriented sections: examples on impurity and degradation profiling as well as enantiomeric analysis.     

Electrochemical reduction of 1-([(4-halophenyl)imino]methyl)-2-naphthols in aprotic media.

The electrochemical reduction of 1-([(4-halophenyl)imino]methyl)-2-naphthols on graphite electrodes was studied using cyclic voltammetry, chronoamperometry, constant-potential coulometry and preparative constant-potential electrolysis techniques. The data revealed that the reduction on graphite was irreversible and followed an EC mechanism. The diffusion coefficients and the number of electrons transferred were determined using the chronoamperometric Cottrell slope and the ultramicro disc Pt-electrode steady-state current. The number of electrons was also determined by bulk electrolysis. The compounds were subjected to constant-potential preparative electrolysis and the electrolysis products were purified and identified by spectroscopic methods. Based on these findings, a mechanism for the electro-reduction process is proposed.     

Synthesis of Novel Monomeric Dyes with Anthraquinone Residue

Two novel polymerizable dyes with anthraquinone residue have been prepared, and their structures were characterized by FTIR, ^1HNMR and EA.