Coalescing binaries—Probe of the universe

At present, coalescing binary systems containing neutron stars or black holes are thought to be the most likely sources of gravitational waves to be detected by long baseline interferometers being currently designed. In this essay we calculate the characteristics of the signal from a coalescing binary to the first post-Newtonian order. We show that at coalescence the eccentricity of the orbit, tidal effects, and magnetic interactions can be neglected. We also consider the effects of the expansion of the universe on the signal. We show that observations of gravitational waves from coalescing binaries by a network of detectors will provide a wealth of astrophysical information, e.g., determination of the Hubble constant, new rungs on the cosmic distance ladder, estimates of the masses of components of the binary systems, information about the mass distribution in the universe, highly accurate tests of general relativity, and constraints on neutron-star equations of state. Further development of laser interferometers may enable determination of the deceleration parameter, provide new information about evolution of the universe, and even enable observation of such effects as gravitational lensing.This essay received the second award from the Gravity Research Association for the year 1987-Ed.On leave of absence from Mathematical Institute, Polish Academy of Science, Warsaw, Poland.     

Pseudotensors in asymptotically curvilinear coordinates

We show how to calculate pseudotensor-based conserved quantities for isolated systems in general relativity, in a way which allows an arbitrary asymptotic behavior of the coordinate system used. Our method is a generalization of that given by Persides [1], and allows the asymptotic evaluation of energy, momentum, and angular momentum in any coordinate system. We carry out the calculation for the Schutz-Sorkin gravitational Noether operator, which is a pseudotensorial operator on vector fields that reduces to the familiar pseudotensors for particular choices of the fields.     

Nouveaux développements de la rhéologie des solutions macromoléculaires concentrées

Sans résuméEn l'honneur de Madame le ProfesseurE. Huseman à l'occasion de son 60e anniversaire.Communication présentée à la Deutsche Rheologische Gesellschaft à Berlin, le 20 Mai 1968.     

THE DESIGN AND IN VITRO RELEASE CHARACTERIZATION OF HUMAN CROSS-LINKED HAEMOSLDBIN MICROCAPSULES CONTAINING DOXORUBICIN FOR POTENTIAL CHEMOEMBOLIZATION USE

Cross-linked human haemoglobin microcapsules were prepared by reacting native haemoglobin with terephthaloyl chloride using an interfacial polymerization process. Low cross-linking agent concentration, and short time reaction produced weakly cross-linked microcapsules which incorporated 707. of the doxorubicin by adsorption from aqueous solution. Only small amounts of doxorubicin were released from the microcapsules in distilled water over 24 hours. However, the presence of electalytes in the aqueous sink solution altered profoundly the release profile of doxorubicin and significantly increased the release rate of the drug. These results suggest that there was a competitive fixation of the cation an the binding sites, identified as carboxyl groups available to the drug molecules. Release profile of doxorubicin from the microcapsules was analyzed according to kinetic models using the non-linear regression search procedure. Doxorubicin release from the microcapsules was found to be controlled by an ion-exchange particle diffusion process. This was confirmed by the “interruption test” which is considered the best technique for distinguishing between particle and film diffusion controlled kinetic process     

Conception and Evaluation of a Library of Cleavable Mass Tags for Digital Polymers Sequencing

A library of phosphoramidite monomers containing a main-chain cleavable alkoxyamine and a side-chain substituent of variable molar mass (i.e. mass tag) was prepared in this work. These monomers can be used in automated solid-phase phosphoramidite chemistry and therefore incorporated periodically as spacers inside digitally-encoded poly(phosphodiester) chains. Consequently, the formed polymers contain tagged cleavable sites that guide their fragmentation in mass spectrometry sequencing and enhance their digital readability. The spacers were all prepared via a seven steps synthetic procedure. They were afterwards tested for the synthesis and sequencing of model digital polymers. Uniform digitally-encoded polymers were obtained as major species in all cases, even though some minor defects were sometimes detected. Furthermore, the polymers were decoded in pseudo-MS³ conditions, thus confirming the reliability and versatility of the spacers library.