Valeria Viviana Belloni;Mostafa Hassan;Luca Furfaro;Remo Giust;Anne-Magali Seydoux-Guillaume;Sergio Sao-Joao;Francois Courvoisier; 《Laser u0026amp; Photonics Reviews》2024,18(3):2300687

Engineering the polarization and spatial phase of ultrafast laser pulses represents a compelling strategy for enhancing control over laser–matter interaction and enabling rapid and innovative nano-fabrication processes. Here, the single-shot, ultrafast laser fabrication of high-aspect-ratio, vertically standing nano-pillars with a diameter of ≈800$approx 800$ nm and height up to 15 µm on the surface of sapphire, is reported. To achieve this, the distinctive properties of diffraction-free, first-order Bessel beams endowed with either radial or azimuthal polarization distributions, are harnessed under tight focusing conditions. The highly intense laser–matter interaction in this configuration generates a tubular-shaped, high-pressure field beneath the material surface, leading to the rapid expulsion of material across the surface. Three distinct regimes for the pillar generation are identified in addition to a mechanism based on the Rayleigh-Plateau theory that explains the distinct morphological regimes observed. The findings not only shed light on the underlying physical mechanisms of intense excitation of transparent dielectrics but also offer exciting prospects for the rapid fabrication of positive nano-structures and material compression across various fields of application.  相似文献   

    

Mohsen M. Mostafa  Abdelmonem H. Elaskalany  Doaa E. El-Kkholy 《应用有机金属化学》2020,34(9):e5734

A novel and efficient synthesis of 1-[(1,2,4-triazole-4-yl)imino]diacetyl monoxime ( L ) is described. The advantages of this method are that it is inexpensive, the starting reactants are readily available, and it has good yield and short reaction times. The hull of the product was suggested by elemental analyses, spectral and single crystal X-ray. Novel Co ²⁺ , Pd²⁺, and Fe ³⁺ chelates derived from L were characterized by Fourier transform infrared spectroscopy, suggesting that L acts as bidentate via the two azomethine groups. Tetrahedral geometry for Fe³⁺ and Co²⁺ and square-planar geometry around the Pd²⁺ chelate were suggested depending on the spectral and magnetic data. The results of density functional theory were applied to illustrate the geometry of L towards the metal ions. Coats–Redfern and Horowitz–Metzger methods were applied to investigate the kinetic and thermodynamic parameters of the chelates. Cyclic voltammetry was carried out to study the stability of the Co²⁺ and Fe³⁺ chelates. L and its complexes were tested against three types of cancer cells, antibacterial and antifungal.  相似文献   

    

Mostafa Abbaszadeh  Mehdi Dehghan  Ionel Michael Navon 《国际流体数值方法杂志》2020,92(10):1415-1436

In the recent decade, the meshless methods have been handled for solving most of PDEs due to easiness of the meshless methods. One of the popular meshless methods is the element-free Galerkin (EFG) method that was first proposed for solving some problems in the solid mechanics. The test and trial functions of the EFG are based on the special basis. Recently, some modifications have been developed to improve the EFG method. One of these improvements is the variational multiscale EFG procedure. In the current article, the shape functions of interpolation moving least squares approximation have been applied to the variational multiscale EFG technique for solving the incompressible magnetohydrodynamics flow. In order to reduce the elapsed CPU time of simulation, we employ a reduced-order model based on the proper orthogonal decomposition technique. The current combination can be referred to as the reduced-order variational multiscale EFG technique. To illustrate the reduction in CPU time used as well as the efficiency of the proposed method, we applied it for the two-dimensional cases.  相似文献   

    

Mohammadreza Moghaddam-manesh  Hamid Beyzaei  Mostafa Heidari Majd  Sara Hosseinzadegan  Kiarash Ghazvini 《Journal of heterocyclic chemistry》2021,58(7):1525-1530

In this study, anticancer, antibacterial (against hospital-isolated antibiotic-resistant Escherichia coli strains), antifungal, and antioxidant effects of synthesized heterocyclic compounds 5 and 7 containing thiazole core were examined. Cytotoxicity testing was utilized against MCF-7 breast cancer cells via MTT cell viability assay. Antibacterial and antifungal activities were checked out according to Clinical and Laboratory Standards Institute (CLSI) guidelines, and antioxidant properties were evaluated through scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals. Results showed the viability of breast cancer cell lines was reliant on concentration of heterocycles and time of incubation. Synthetic compounds exhibited excellent antibacterial and antifungal properties base on their minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) values as well as high antioxidant activities according to their IC₅₀ values. Higher anticancer and antibacterial properties were observed with compound 7; on the contrary, thiazole 5 had better antioxidant effects. They can be introduced as potent antimicrobial, antioxidant, and anticancer agents.  相似文献   

    

Marjan Abdi Jamali  Alireza Arvani  Prof. Dr. Mostafa M. Amini 《ChemCatChem》2021,13(1):293-303

The wet impregnation method was applied to prepare vanadium species on the chromium(III) terephthalate metal-organic framework (MIL-101) and on the aluminum fumarate metal-organic framework (A520), two highly efficient catalysts, as well as vanadium species on the zinc terephthalate metal-organic framework (MOF-5), using vanadium(V) oxytributoxide as a precursor. The prepared catalysts were characterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDX), N₂ sorption measurement (BET), thermal analysis (TGA-DTA), and X-ray photoelectron spectroscopy (XPS). The prepared materials were utilized as catalysts for the oxidation of the refractory aromatic sulfur compound, dibenzothiophene (DBT), in a model diesel fuel. The catalytic oxidation of DBT to DBT-sulfone was performed in the presence of tert-butyl hydroperoxide (TBHP) under mild operating conditions. The heterogeneous catalysts, OV(O^tBu)_3−x(OH)_x@MIL-101(Cr), OV(O^tBu)_3−x(OH)_x@A520, and OV(O^tBu)_3−x(OH)_x@MOF-5 demonstrated activities of 98, 98, and 10 %, respectively, in the oxidative desulfurization (ODS) process at 60 °C. The catalysts were recycled easily and reused without a significant decrease in their activity. The oxidation of DBT to DBT-sulfone was investigated using gas chromatography, and the formation of DBT-sulfone was confirmed by FT-IR and ¹H NMR spectroscopies.  相似文献   

    

Wahid M. Basyouni  Samir Y. Abbas  Khairy A. M. El-Bayouki  Reham M. Dawood  Mostafa K. El Awady  Tawfeek H. Abdelhafez 《Journal of heterocyclic chemistry》2021,58(9):1766-1774

7-Chloro-2-(propylthio)thiazolo[5,4-d]pyrimidine 4 was prepared and used as a precursor for synthesizing new derivatives of thiazolo[5,4-d]pyrimidine through the nucleophilic displacement of the chlorine atom by different types of amino derivatives. Reaction of compound 4 with primary and secondary amines produced the corresponding substituted amino derivatives. Reaction of 4 with hydrazine hydrate then followed by condensation with aromatic aldehydes afforded hydrazone derivatives. Reaction of 4 with hydrazine hydrate then followed by reaction with isothiocyanates gave the disubstituted thiosemicarbazides. Finally, treatment of 4 with hydrazine derivatives afforded the novel disubstituted hydrazine derivatives. Preliminary antiviral screening on the bovine viral diarrhea virus (BVDV) was carried out, which was classified as a member of the same family of Hepatitis C virus. The results indicated that some of the tested compounds exhibited anti-BVDV activity which may be suitable for a new lead molecule to design more potent anti-BVDV agents.  相似文献   

    

Abdulnasir A. Majeed  Mostafa M.H. Khalil  Ahmed Fetoh  Ayman A. Abdel Aziz  G.M. Abu El‐Reash 《应用有机金属化学》2021,35(1)

In this work, (Z)‐N‐benzoyl‐N′‐(1H‐1,2,4‐triazol‐3‐yl)carbamimidothioic acid and its Mn(II), Co(II), Cu(II) and Cd(II) complexes were introduced for the first time. This carbonyl thiourea ligand was prepared by the reaction of 1H‐1,2,4‐triazol‐3‐amine with benzoyl isothiocyanate. The structural elucidation of these compounds was performed using elemental analysis and spectral and magnetic measurements. Octahedral structures of all complexes, except Cd(II) complex with a tetrahedral geometry, were confirmed by applying DFT structural optimization. The thermal decomposition behaviour of metal complexes of carbonyl thiourea ligand is discussed. The calculation of kinetic parameters for prepared complexes (E_a, A, ΔH*, ΔS* and ΔG*) of all thermal degradation stages has been evaluated using two comparable approaches. Antimicrobial and ABTS‐antioxidant studies indicated potent activity of Cd(II) complex compared with the other investigated compounds. The cytotoxic activity of the prepared compounds was investigated in vitro. The results indicated potent activity of Mn(II) complex against both HePG2 (liver carcinoma) and MCF‐7 (breast carcinoma) cancer cells.  相似文献   

    

Mostafa Abdelrahman  Sho Hirata  Takuya Mukae  Tomohiro Yamada  Yuji Sawada  Magdi El-Syaed  Yutaka Yamada  Muneo Sato  Masami Yokota Hirai  Masayoshi Shigyo 《Molecules (Basel, Switzerland)》2021,26(5)

Garlic (Allium sativum) is the second most important Allium crop that has been used as a vegetable and condiment from ancient times due to its characteristic flavor and taste. Although garlic is a sterile plant that reproduces vegetatively through cloves, garlic shows high biodiversity, as well as phenotypic plasticity and environmental adaptation capacity. To determine the possible mechanism underlying this phenomenon and to provide new genetic materials for the development of a novel garlic cultivar with useful agronomic traits, the metabolic profiles in the leaf tissue of 30 garlic accessions collected from different geographical regions, with a special focus on the Asian region, were investigated using LC/MS. In addition, the total saponin and fructan contents in the roots and cloves of the investigated garlic accessions were also evaluated. Total saponin and fructan contents did not separate the garlic accessions based on their geographical origin, implying that saponin and fructan contents were clone-specific and agroclimatic changes have affected the quantitative and qualitative levels of saponins in garlic over a long history of cultivation. Principal component analysis (PCA) and dendrogram clustering of the LC/MS-based metabolite profiling showed two major clusters. Specifically, many Japanese and Central Asia accessions were grouped in cluster I and showed high accumulations of flavonol glucosides, alliin, and methiin. On the other hand, garlic accessions grouped in cluster II exhibited a high accumulation of anthocyanin glucosides and amino acids. Although most of the accessions were not separated based on country of origin, the Central Asia accessions were clustered in one group, implying that these accessions exhibited distinct metabolic profiles. The present study provides useful information that can be used for germplasm selection and the development of new garlic varieties with beneficial biotic and abiotic stress-adaptive traits.  相似文献   

    

Hani A. Alhadrami  Ahmed M. Sayed  Ahmed M. Sharif  Esam I. Azhar  Mostafa E. Rateb 《Molecules (Basel, Switzerland)》2021,26(9)

SARS CoV-2 pandemic is still considered a global health disaster, and newly emerged variants keep growing. A number of promising vaccines have been recently developed as a protective measure; however, cost-effective treatments are also of great importance to support this critical situation. Previously, betulinic acid has shown promising antiviral activity against SARS CoV via targeting its main protease. Herein, we investigated the inhibitory potential of this compound together with three other triterpene congeners (i.e., ursolic acid, maslinic acid, and betulin) derived from olive leaves against the viral main protease (M^pro) of the currently widespread SARS CoV-2. Interestingly, betulinic, ursolic, and maslinic acids showed significant inhibitory activity (IC₅₀ = 3.22–14.55 µM), while betulin was far less active (IC₅₀ = 89.67 µM). A comprehensive in-silico analysis (i.e., ensemble docking, molecular dynamic simulation, and binding-free energy calculation) was then performed to describe the binding mode of these compounds with the enzyme catalytic active site and determine the main essential structural features required for their inhibitory activity. Results presented in this communication indicated that this class of compounds could be considered as a promising lead scaffold for developing cost-effective anti-SARS CoV-2 therapeutics.  相似文献   

    

Noureddine Bencheikh  Mohamed Bouhrim  Loubna Kharchoufa  Omkulthom Mohamed Al Kamaly  Hamza Mechchate  Imane Es-safi  Ahmed Dahmani  Sabir Ouahhoud  Soufiane El Assri  Bruno Eto  Mohamed Bnouham  Mohammed Choukri  Mostafa Elachouri 《Molecules (Basel, Switzerland)》2021,26(16)

Zizyphus lotus L. (Desf.) (Z. lotus) is a medicinal plant largely distributed all over the Mediterranean basin and is traditionally used by Moroccan people to treat many illnesses, including kidney failure. The nephrotoxicity of gentamicin (GM) has been well documented in humans and animals, although the preventive strategies against it remain to be studied. In this investigation, we explore whether the extract of Zizyphus lotus L. (Desf.) Fruit (ZLF) exhibits a protective effect against renal damage produced by GM. Indeed, twenty-four Wistar rats were separated into four equal groups of six each (♂/♀ = 1). The control group was treated orally with distilled water (10 mL/kg); the GM treated group received distilled water (10 mL/kg) and an intraperitoneal injection of GM (80 mg/kg) 3 h after; and the treated groups received ZLF extract orally at the doses 200 or 400 mg/kg and injected intraperitoneally with the GM. All treatments were given daily for 14 days. At the end of the experiment, the biochemical parameters and the histological observation related the kidney function was explored. ZLF treatment has significantly attenuated the nephrotoxicity induced by the GM. This effect was indicated by its capacity to decrease significantly the serum creatinine, uric acid, urea, alkaline phosphatase, gamma-glutamyl-transpeptidase, albumin, calcium, sodium amounts, water intake, urinary volume, and relative kidney weight. In addition, this effect was also shown by the increase in the creatinine clearance, urinary creatinine, uric acid, and urea levels, weight gain, compared to the rats treated only with the GM. The hemostasis of oxidants/antioxidants has been significantly improved with the treatment of ZLF extract, which was shown by a significant reduction in malondialdehydes levels. Histopathological analysis of renal tissue was correlated with biochemical observation. Chemical analysis by HPLC-DAD showed that the aqueous extract of ZLF is rich in phenolic compounds such as 3-hydroxycinnamic acid, catechin, ferulic acid, gallic acid, hydroxytyrosol, naringenin, p- coumaric Acid, quercetin, rutin, and vanillic acid. In conclusion, ZLF extract improved the nephrotoxicity induced by GM, through the improvement of the biochemical and histological parameters and thus validates its ethnomedicinal use.  相似文献