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We explore the effect of the external magnetic and Aharonov–Bohm (AB) flux fields on the energy levels of Dirac particle subjects to mixed scalar and vector anharmonic oscillator field in the two-dimensional (2D) space. We calculate the exact energy eigenvalues and the corresponding un-normalized two-spinor-components wave functions in terms of the chemical potential parameter, magnetic field strength, AB flux field and magnetic quantum number by using the Nikiforov–Uvarov (NU) method. 相似文献
64.
Sameer Chavda 《Tetrahedron letters》2008,49(52):7398-7402
The resolution of a series of active esters (derived from acetyl mandelic acid) using an equimolar combination of quasi-enantiomeric oxazolidin-2-ones is discussed. The levels of diastereoselectivity and the facial selectivity were found to be dependent on the structural nature of the pro-leaving group. 相似文献
65.
Angus S. Mackay Joshua W. C. Maxwell Max J. Bedding Dr. Sameer S. Kulkarni Dr. Stephen A. Byrne Lucas Kambanis Dr. Mihai V. Popescu Prof. Robert S. Paton Assoc. Prof. Lara R. Malins Dr. Anneliese S. Ashhurst Dr. Leo Corcilius Prof. Richard J. Payne 《Angewandte Chemie (International ed. in English)》2023,62(50):e202313037
Mild strategies for the selective modification of peptides and proteins are in demand for applications in therapeutic peptide and protein discovery, and in the study of fundamental biomolecular processes. Herein, we describe the development of an electrochemical selenoetherification (e-SE) platform for the efficient site-selective functionalization of polypeptides. This methodology utilizes the unique reactivity of the 21st amino acid, selenocysteine, to effect formation of valuable bioconjugates through stable selenoether linkages under mild electrochemical conditions. The power of e-SE is highlighted through late-stage C-terminal modification of the FDA-approved cancer drug leuprolide and assembly of a library of anti-HER2 affibody conjugates bearing complex cargoes. Following assembly by e-SE, the utility of functionalized affibodies for in vitro imaging and targeting of HER2 positive breast and lung cancer cell lines is also demonstrated. 相似文献
66.
Talreja S Kenis PJ Zukoski CF 《Langmuir : the ACS journal of surfaces and colloids》2007,23(8):4516-4522
The quality, size, and number of protein crystals grown under conditions of continuous solvent extraction are dependent on the rate of solvent extraction and the initial protein and salt concentration. An increase in the rate of solvent extraction leads to a larger number of crystals. The number of crystals decreases, however, when the experiment is started with an initial protein concentration that is closer to the solubility boundary. Here we develop a kinetic model capable of predicting changes in the number and size of protein crystals as a function of time under continuous evaporation. Moreover, this model successfully predicts the initial condition of drops that will result in gel formation. We test this model with experimental crystal growth data of hen egg white lysozyme for which crystal nucleation and growth rate parameters are known from other studies. The predicted and observed rates of crystal growth are in excellent agreement, which suggests that kinetic constants for nucleation and crystal growth for different proteins can be extracted by applying a kinetic model in combination with observations from a few evaporation-based crystallization experiments. 相似文献
67.
The physical properties of lipid bilayers can be remodeled by a variety of environmental factors. Here we investigate using molecular dynamics simulations the specific effects of nanoscopic substrates or external contact points on lipid membranes. We expose palmitoyl-oleoyl phosphatidylcholine bilayers unilaterally and separately to various model nanosized substrates differing in surface hydroxyl densities. We find that a surface hydroxyl density as low as 10% is sufficient to keep the bilayer juxtaposed to the substrate. The bilayer interacts with the substrate indirectly through multiple layers of water molecules; however, despite such buffered interaction, the bilayers exhibit certain properties different from unsupported bilayers. The substrates modify transverse lipid fluctuations, charge density profiles, and lipid diffusion rates, although differently in the two leaflets, which creates an asymmetry between bilayer leaflets. Other properties that include lipid cross-sectional areas, component volumes, and order parameters are minimally affected. The extent of asymmetry that we observe between bilayer leaflets is well beyond what has been reported for bilayers adsorbed on infinite solid supports. This is perhaps because the bilayers are much closer to our nanosized finite supports than to infinite solid supports, resulting in a stronger support-bilayer electrostatic coupling. The exposure of membranes to nanoscopic contact points, therefore, cannot be considered as a simple linear interpolation between unsupported membranes and membranes supported on infinite supports. In the biological context, this suggests that the exposure of membranes to nonintercalating proteins, such as those belonging to the cytoskeleton, should not always be considered as passive nonconsequential interactions. 相似文献
68.
Kozub DR Vakhshouri K Kesava SV Wang C Hexemer A Gomez ED 《Chemical communications (Cambridge, England)》2012,48(47):5859-5861
Through a combination of X-ray scattering and energy-filtered electron microscopy, we have quantitatively examined the relationship between the mesostructure of the photoactive layer and device performance in PBTTT/PC(71)BM solar cells. We can predict device performance from X-ray structural data through a simple morphological model which includes the exciton diffusion length. 相似文献
69.
Kulatilaka WD Chai N Naik SV Laurendeau NM Lucht RP Kuehner JP Roy S Gord JR 《Optics letters》2006,31(22):3357-3359
We have measured nitric oxide (NO) concentrations in flames by using electronic-resonance-enhanced coherent anti-Stokes Raman spectroscopy (ERE-CARS). Visible pump and Stokes beams were tuned to a Q-branch vibrational Raman resonance of NO. A UV probe beam was tuned into resonance with specific rotational transitions in the (v"=1,v'=0) vibrational band in the A(2)Sigma(+)-X(2)Pi electronic transition, thus providing a substantial electronic-resonance enhancement of the resulting CARS signal. NO concentrations were measured at levels down to 50 parts in 10(6) in H(2)/air flames at atmospheric pressure. NO was also detected in heavily sooting C(2)H(2)/air flames at atmospheric pressure with minimal background interference. 相似文献
70.
We study the approximate analytical solutions of the Dirac equation for the generalized Woods-Saxon potential with the pseudo-centrifugal term. We apply the Nikiforov-Uvarov method (which solves a second-order linear differential equation by reducing it to a generalized hypergeometric form) to spin- and pseudospin-symmetry to obtain, in closed form, the approximately analytical bound state energy eigenvalues and the corresponding upper- and lower-spinor components of two Dirac particles. The special cases κ = ±1 (s = $ \tilde l $ = 0, s-wave) and the non-relativistic limit can be reached easily and directly for the generalized and standard Woods-Saxon potentials. We compare the non-relativistic results with those obtained by others. 相似文献