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61.
Tarik E. Ali Salah A. Abdel-Aziz Somaya M. El-Edfawy El-Hossain A. Mohamed Somaia M. Abdel-Kariem 《合成通讯》2014,44(24):3610-3629
A convenient synthetic approach leading to a series of novel substituted azoles, azines, and azepines linked to the α-aminophosphonate moiety was achieved. The methodology depends on ring opening and ring closure (RORC) of the chromone ring of diethyl chromonyl α-aminophosphonate 1 via its reaction with nitrogen nucleophiles such as primary amines and 1,2-, 1,3-, and 1,4-bi-nucleophiles in ethanolic sodium ethoxide. Also, treatment of compound 1 with some acyclic and cyclic active methylene compounds under the same reaction conditions afforded interesting novel isolated and fused pyridine systems bearing phosphonate groups at the α-position. The screening of antimicrobial activity for the synthesized compounds indicates that connection of pyrazole, oxazepine, and benzodiazepine rings with α-aminophosphonate moiety exhibited good antimicrobial effects. Also, evaluation of their antioxidant properties shows that the compounds having 1,5-benzoxazepinyl and 1,5-benzodiazepinyl units in combination with α-aminophosphonic diester moiety are the most powerful antioxidant agents. 相似文献
62.
Ethyl 7‐amino‐3‐(3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐5‐aryl‐5H‐thiazolo[3,2‐a]pyrimidine‐6‐carboxylate was hydrolyzed with an ethanolic sodium hydroxide and the sodium salt thus formed underwent cyclization with acetic anhydride to afford 2‐methyl‐7‐(3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐5‐arylthiazolo[3,2‐a]pyrimido[4,5‐d]oxazin‐4(5H)‐one. This compound was transformed to related heterocyclic systems via its reaction with various reagents. The biological activity of the prepared compounds was tested against Gram positive and Gram negative bacteria as well as yeast‐like and filamentous fungi. They revealed in some cases excellent biocidal properties. 相似文献
63.
Here we report an effective method for protein immobilization on a surface plasmon resonance (SPR) gold chip, describing the combination of cysteine- and oligomerization domain-mediated immobilization of enhanced green fluorescent protein (EGFP) as a model protein for the purpose of orientation-controlled surface density packing. In order to facilitate the oligomerization of EGFP, the dimeric and trimeric constructs derived from GCN4- leucine zipper domain were chosen for multimeric EGFP assembly. For orientation-controlled immobilization of the protein, EGFP modified with cysteine residues showing excellent orientation on a gold chip was used as a starting protein, as previously reported in our earlier study (Anal. Chem., 2007, 79, 2680-2687). Constructs of EGFP with oligomerization domains were genetically engineered, and corresponding fusion proteins were purified, applied to a gold chip, and then analyzed under SPR. The immobilized EGFP density on a gold chip increased according to the states of protein oligomerization, as dimeric and trimeric EGFPs displayed better adsorption capability than monomeric and dimeric forms, respectively. Fluorescence measurement corroborated the SPR results. Taken together, our findings indicated that the combination of cysteine- and oligomerization domain-mediated immobilization of protein could be used in SPR biosensor applications, allowing for an excellent orientation and high surface density simultaneously. 相似文献
64.
Youcef Bouizem Salah Boulaaras Bachir Djebbar 《Mathematical Methods in the Applied Sciences》2019,42(7):2465-2474
The paper deals with some existence results for an elliptic equation of Kirchhoff‐type with changing sign data and a logarithmic nonlinearity by direct variational method, Galerkin approach, and sub‐super solutions method. Our results are natural extension of Boulaaras' work in (Math Methods Appl Sci; 41(13):5203‐5210). 相似文献
65.
In this paper, we establish three iteration methods to compute solutions for a class of (weakly) singular two-point boundary value problems (xy′)′=f(x,y), where x(0,1) and <2. We obtain the sufficient conditions for existence of a unique solution on
. Finally, we given some numerical examples. 相似文献
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We give a polynomial time controlled version of a theorem of M. Hall: every real number can be written as the sum of two irrational numbers whose developments into a continued fraction contain only 1, 2, 3 or 4. Mathematics Subject Classification: 03D15, 03F60, 11A55, 68Q25. 相似文献
69.
A mathematical model is presented for the determination of optimal mix of asbestos fibres to satisfy a set of desired pipe properties which vary with pipe size, class, and material availability. The approach utilizes a linear/separable programming model which is aimed at minimizing the total cost of fibres used. The fibre properties, such as reinforcing strength, processability, and length as well as cost and stocks available are taken into account in the model. Also represented are the profile of the ideal mix relative to the required composite strength, processability, and ‘dust content’. Asbestos mixes designed using the model have been implemented in the production of asbestos/cement pipes in one of the asbestos/cement pipe manufacturing plants in the Gulf area. Optimum model mixes have demonstrated significant technical and economic merits over the conventionally designed mixes. 相似文献
70.
An indirect method is outlined for the spectrophotometric determination of small amounts of perchlorate. Perchlorate is quantitatively precipitated as nitron perchlorate in the presence of excess nitron. After separating off the precipitate, the excess reagent is determined in the supernatant liquid as nitron cobaltothiocyanate. The latter compound is extracted in 30% cyclohexanone in carbon tetrachloride and the absorbance of the extract measured at 625 nm. The method is simple, reproducible, and accurate to ±1%. The interferences of other anions were also investigated. 相似文献