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排序方式: 共有137条查询结果,搜索用时 15 毫秒
131.
This paper presents an easily verifiable delay independent sufficient condition for the global robust asymptotic stability of the equilibrium point for bidirectional associative memory (BAM) neural networks with time delays by employing a class of Lyapunov functionals. The obtained results are applicable to all bounded continuous non-monotonic neuron activation functions. Some numerical examples are given to compare our results with the previous robust stability results derived in the literature. 相似文献
132.
Tsun-Thai Chai Clara Chia-Ci Wong Mohamad Zulkeflee Sabri Fai-Chu Wong 《Molecules (Basel, Switzerland)》2022,27(12)
Paramyosins, muscle proteins occurring exclusively in invertebrates, are abundant in seafoods. The potential of seafood paramyosins (SP) as sources of anti-angiotensin-converting-enzyme (ACE) and anti-dipeptidyl-peptidase (DPP-IV) peptides is underexplored. This in silico study investigated the release of anti-ACE and anti-DPP-IV peptides from SP after gastrointestinal (GI) digestion. We focused on SP of the common octopus, Humboldt squid, Japanese abalone, Japanese scallop, Mediterranean mussel, Pacific oyster, sea cucumber, and Whiteleg shrimp. SP protein sequences were digested on BIOPEP-UWM, followed by identification of known anti-ACE and anti-DPP-IV peptides liberated. Upon screening for high-GI-absorption, non-allergenicity, and non-toxicity, shortlisted peptides were analyzed via molecular docking and dynamic to elucidate mechanisms of interactions with ACE and DPP-IV. Potential novel anti-ACE and anti-DPP-IV peptides were predicted by SwissTargetPrediction. Physicochemical and pharmacokinetics of peptides were predicted with SwissADME. GI digestion liberated 2853 fragments from SP. This comprised 26 known anti-ACE and 53 anti-DPP-IV peptides exhibiting high-GI-absorption, non-allergenicity, and non-toxicity. SwissTargetPrediction predicted three putative anti-ACE (GIL, DL, AK) and one putative anti-DPP-IV (IAL) peptides. Molecular docking found most of the anti-ACE peptides may be non-competitive inhibitors, whereas all anti-DPP-IV peptides likely competitive inhibitors. Twenty-five nanoseconds molecular dynamics simulation suggests the stability of these screened peptides, including the three predicted anti-ACE and one predicted anti-DPP-IV peptides. Seven dipeptides resembling approved oral-bioavailable peptide drugs in physicochemical and pharmacokinetic properties were revealed: AY, CF, EF, TF, TY, VF, and VY. In conclusion, our study presented in silico evidence for SP being a promising source of bioavailable and safe anti-ACE and anti-DPP-IV peptides following GI digestions. 相似文献
133.
Nouha Bouali Manel Ben Hammouda Iqrar Ahmad Siwar Ghannay Amira Thouri Amal Dbeibia Harun Patel Walid Sabri Hamadou Karim Hosni Mejdi Snoussi Mohd Adnan Md Imtaiyaz Hassan Emira Noumi Kaïss Aouadi Adel Kadri 《Molecules (Basel, Switzerland)》2022,27(21)
To combat emerging antimicrobial-resistant microbes, there is an urgent need to develop new antimicrobials with better therapeutic profiles. For this, a series of 13 new spiropyrrolidine derivatives were designed, synthesized, characterized and evaluated for their in vitro antimicrobial, antioxidant and antidiabetic potential. Antimicrobial results revealed that the designed compounds displayed good activity against clinical isolated strains, with 5d being the most potent (MIC 3.95 mM against Staphylococcus aureus ATCC 25923) compared to tetracycline (MIC 576.01 mM). The antioxidant activity was assessed by trapping DPPH, ABTS and FRAP assays. The results suggest remarkable antioxidant potential of all synthesized compounds, particularly 5c, exhibiting the strongest activity with IC50 of 3.26 ± 0.32 mM (DPPH), 7.03 ± 0.07 mM (ABTS) and 3.69 ± 0.72 mM (FRAP). Tested for their α-amylase inhibitory effect, the examined analogues display a variable degree of α-amylase activity with IC50 ranging between 0.55 ± 0.38 mM and 2.19 ± 0.23 mM compared to acarbose (IC50 1.19 ± 0.02 mM), with the most active compounds being 5d, followed by 5c and 5j, affording IC50 of 0.55 ± 0.38 mM, 0.92 ± 0.10 mM, and 0.95 ± 0.14 mM, respectively. Preliminary structure–activity relationships revealed the importance of such substituents in enhancing the activity. Furthermore, the ADME screening test was applied to optimize the physicochemical properties and determine their drug-like characteristics. Binding interactions and stability between ligands and active residues of the investigated enzymes were confirmed through molecular docking and dynamic simulation study. These findings provided guidance for further developing leading new spiropyrrolidine scaffolds with improved dual antimicrobial and antidiabetic activities. 相似文献
134.
This study processes a facile and green approach for the Markovnikov-selective hydroamination of styrene with naphthylamine through irradiation with UV LED light (365 nm) via an electron donor–acceptor complexation between naphthylamines and oxygen in situ. This protocol showcases the synthetic potential for aerobic C–N bond formation without using a metal catalyst and photosensitizer. Three naphthylamines were examined and afforded desired C–N bond formation product in moderate yield. 相似文献
135.
Mohamed S. H. Salem Ahmed Sabri Md. Imrul Khalid Hiroaki Sasai Shinobu Takizawa 《Molecules (Basel, Switzerland)》2022,27(24)
A novel double aza-oxa[7]helicene was synthesized from the commercially available N1,N4-di(naphthalen-2-yl)benzene-1,4-diamine and p-benzoquinone in two steps. Combining the acid-mediated annulation with the electrochemical sequential reaction (oxidative coupling and dehydrative cyclization) afforded this double hetero[7]helicene. Moreover, the structural and optical features of this molecule have been studied using X-ray crystallographic analysis, and the absorption and emission behaviors were rationalized based on DFT calculations. 相似文献
136.
Wan Mohamad Ikhmal Wan Mohamad Kamaruzzaman Maria Fazira Mohd Fekeri Nursabrina Amirah Mohd Nasir Nur Aiman Syafiq Mohd Hamidi Mohamad Zahid Baharom Azila Adnan Muhamad Syaizwadi Shaifudin Wan Rafizah Wan Abdullah Wan Mohd Norsani Wan Nik Fariza Hanim Suhailin Khamirul Amin Matori Chen Soo Kien Mohd Hafiz Mohd Zaid Mohd Sabri Mohd Ghazali 《Molecules (Basel, Switzerland)》2021,26(11)
With the trend for green technology, the study focused on utilizing a forgotten herb to produce an eco-friendly coating. Andrographis paniculata or the kalmegh leaves extract (KLE) has been investigated for its abilities in retarding the corrosion process due to its excellent anti-oxidative and antimicrobial properties. Here, KLE was employed as a novel additive in coatings and formulations were made by varying its wt%: 0, 3, 6, 9, and 12. These were applied to stainless steel 316L immersed in seawater for up to 50 days. The samples were characterized and analyzed to measure effectiveness of inhibition of corrosion and microbial growth. The best concentration was revealed to be 6 wt% KLE; it exhibited the highest performance in improving the ionic resistance of the coating and reducing the growth of bacteria. 相似文献
137.
Sabri Touidjine Moulai Karim Boulkadid Djalal Trache Samir Belkhiri Hamdane Akbi Anes Abdessamed 《国际化学动力学杂志》2023,55(2):72-86
Polyester (HTPS) based polyurethane (PU) elastomers were currently established to be effective binders for high-energy composites with improved performances. Conventional PU binders are mostly non-energetic materials, and consequently reduce the energy performance significantly. Nitrocellulose (NC), is an energetic polymer widely used as an ingredient in propellants, explosives, fireworks, and gas generators, it may be introduced in PU-based compositions to overcome their performance drawback. Kinetic parameters must be specified in order to build PU binders with the most convenient and appropriate features. Therefore, the cure kinetics of polyester based polyurethane binder systems were investigated by Fourier transform infrared spectroscopy (FT-IR) isothermal method. The polyester prepolymer (Desmophen® 1200) was cured with hexamethylene diisocyanate (HDI: Desmodur® N100) at various molar ratios (R[NCO]/[OH] = 0.6, 1, 1.25, and 1.5) and under different isothermal conditions (T = 60°C, 80°C, 100°C, and 120°C). In addition, the effect of the addition of nitrocellulose on the kinetics of polymerization of PU was investigated. The progression of the reaction was followed based on the decrease of the peak intensity of –NCO group at 2271 cm−1 as a function of the reaction time. The curing kinetic model and the apparent activation energy (Eα) were determined by the use of Kamal autocatalytic model and Friedman isoconversional method, respectively. 相似文献