全文获取类型
收费全文 | 1500篇 |
免费 | 80篇 |
专业分类
化学 | 1333篇 |
晶体学 | 3篇 |
力学 | 11篇 |
数学 | 101篇 |
物理学 | 132篇 |
出版年
2023年 | 7篇 |
2022年 | 17篇 |
2021年 | 24篇 |
2020年 | 36篇 |
2019年 | 31篇 |
2018年 | 18篇 |
2017年 | 5篇 |
2016年 | 54篇 |
2015年 | 52篇 |
2014年 | 46篇 |
2013年 | 66篇 |
2012年 | 90篇 |
2011年 | 131篇 |
2010年 | 70篇 |
2009年 | 79篇 |
2008年 | 85篇 |
2007年 | 91篇 |
2006年 | 82篇 |
2005年 | 70篇 |
2004年 | 71篇 |
2003年 | 61篇 |
2002年 | 59篇 |
2001年 | 27篇 |
2000年 | 19篇 |
1999年 | 23篇 |
1998年 | 23篇 |
1997年 | 27篇 |
1996年 | 26篇 |
1995年 | 19篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 11篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 6篇 |
1985年 | 9篇 |
1984年 | 6篇 |
1983年 | 3篇 |
1982年 | 9篇 |
1981年 | 7篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 8篇 |
1977年 | 5篇 |
1974年 | 2篇 |
1973年 | 4篇 |
1932年 | 2篇 |
1891年 | 2篇 |
排序方式: 共有1580条查询结果,搜索用时 15 毫秒
991.
Thomas Gutberlet Sabine Markwitz Harald Labischinski Hans Bradaczek 《Macromolecular Symposia》1991,46(1):283-287
Lipoteichoic acid (LTA) and mixtures of LTA with dipalmitoyldiphosphatidylglycerol (DPPG) were investigated with Langmuir-Blodgett techniques. In spite of its large hydrophilic portion LTA formed a monolayer when spread from a chloro-form/n-propanol/water system. In DPPG/LTA-mixed monolayers LTA influenced strongly the compression isotherms, indicating a stabilizing effect of LTA on DPPG monolayers. At higher concentrations of LTA phase separation was observed. 相似文献
992.
Zeyad I. Alehaideb Anuradha Venkatraman Mahadev Kokane Syed Ali Mohamed Saranya Rameshbabu Rasha S. Suliman Sahar S. Alghamdi Hamad Al-Eidi Bandar Alghanem Maha-Hamadien Abdulla Sabine Matou-Nasri 《Molecules (Basel, Switzerland)》2022,27(3)
Liver cancer is a leading cause of cancer death globally. Marine mollusc-derived drugs have gained attention as potential natural-based anti-cancer agents to overcome the side effects caused by conventional chemotherapeutic drugs during cancer therapy. Using liquid chromatography-mass spectrometry, the main biomolecules in the purple ink secretion released by the sea hare, named Bursatella leachii (B. leachii), were identified as hectochlorin, malyngamide X, malyngolide S, bursatellin and lyngbyatoxin A. The cytotoxic effects of B. leachii ink concentrate against human hepatocarcinoma (HepG2) cells were determined to be dose- and time-dependent, and further exploration of the underlying mechanisms causing the programmed cell death (apoptosis) were performed. The expression of cleaved-caspase-8 and cleaved-caspase-3, key cysteine-aspartic proteases involved in the initiation and completion of the apoptosis process, appeared after HepG2 cell exposure to the B. leachii ink concentrate. The gene expression levels of pro-apoptotic BAX, TP53 and Cyclin D1 were increased after treatment with the B. leachii ink concentrate. Applying in silico approaches, the high scores predicted that bioactivities for the five compounds were protease and kinase inhibitors. The ADME and cytochrome profiles for the compounds were also predicted. Altogether, the B. leachii ink concentrate has high pro-apoptotic potentials, suggesting it as a promising safe natural product-based drug for the treatment of liver cancer. 相似文献
993.
Sabine Kpper 《Nachrichten aus der Chemie》1992,40(10):1121-1123
994.
Ignacio Caretti Bart Dervaux Filip E. Du Prez Sabine Van Doorslaer 《Journal of polymer science. Part A, Polymer chemistry》2010,48(7):1493-1501
Identification of the paramagnetic species present in the Cu(I)Br‐catalyzed atom transfer radical polymerization (ATRP) of a model monomer (isobornyl acrylate) has been carried out by electron paramagnetic resonance (EPR) in the continuous wave mode at 90 K. Up to five different species—four copper‐based species and one organic radical—were detected with this technique. The EPR parameters of the copper‐based species are found to differ strongly, and originate from diverse isolated Cu(II) complexes, as well as dipolarly interacting and even exchange‐coupled Cu(II) species. The work highlights the complexity of the copper‐based EPR signal observed in copper‐mediated ATRP reactions. Analysis of the time evolution of the individual EPR contributions reveals the disadvantages of quantitative kinetics studies based on the summed EPR intensity of all copper‐based species, as is commonly used in literature for this type of reactions. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1493–1501, 2010 相似文献
995.
Daniela Volke Mohammed Daghish Lothar Hennig Matthias Findeisen Sabine Giesa Ramona Oehme Peter Welzel 《Helvetica chimica acta》2003,86(12):4214-4232
The synthesis of some 3‐aryl‐3‐(trifluoromethyl)3H‐diazirine and benzophenone‐based photoaffinity labels is reported. The photolabile group is bound to a scaffold that also accommodates functional groups to which an indicator unit (biotin) and the bioactive ligand can be attached orthogonally. To three of the labels, moenomycin was conjugated with the aim to provide tools for the identification of the moenomycin binding site within the transglycosylase domain of the enzyme PBP 1b. Some preliminary photoaffinity‐labeling experiments were carried out. 相似文献
996.
997.
Jens Totz Aad van den Boogaart Sabine Van Huffel Danielle Graveron-Demilly Ioannis Dologlou Ralf Heidler Dieter Michel 《Journal of magnetic resonance (San Diego, Calif. : 1997)》1997,124(2):400-409
In this paper, it is shown how the advantages of continuous regularization (CR) can be exploited to achieve an improved, fully automated LPSVD analysis of MRS time-domain data. The main advantage of CR is its ability to determine the number of spectral components even at low signal-to-noise ratios, which suggested its use forin vivospectroscopy. Estimation of the spectral parameters is possible. Two alternatives of automated data-analysis schemes are thoroughly investigated by means of Monte Carlo studies. The results suggest the combination of CR for model-order estimation with other methods for more-accurate parameter estimation. Several possible combinations, including those with an improved enhancement procedure and a total-least-squares method for quantitation, are discussed. Recommendations are given for spectral analysis, and a new data-analysis protocol which performs significantly better than previously used protocols of the same type is proposed. 相似文献
998.
999.