Synthesis,Thermal Behavior,and Dehydrogenation Kinetics Study of Lithiated Ethylenediamine

The lithiation of ethylenediamine by LiH is a stepwise process to form the partially lithiated intermediates LiN(H)CH₂CH₂NH₂ and [LiN(H)CH₂CH₂NH₂][LiN(H)CH₂CH₂N(H)Li]₂ prior to the formation of dilithiated ethylenediamine LiN(H)CH₂CH₂N(H)Li. A reversible phase transformation between the partial and dilithiated species was observed. One dimensional {Li_nN_n} ladders and three‐dimensional network structures were found in the crystal structures of LiN(H)CH₂CH₂NH₂ and LiN(H)CH₂CH₂N(H)Li, respectively. LiN(H)CH₂CH₂N(H)Li undergoes dehydrogenation with an activation energy of 181±8 kJ mol^?1, whereas the partially lithiated ethylenediamine compounds were polymerized and released ammonia at elevated temperatures. The dynamical dehydrogenation mechanism of the dilithiated ethylenediamine compounds was investigated by using the Johnson‐Mehl‐Avrami equation.     

Macrocyclic Protease Inhibitors with Reduced Peptide Character

There is a real need for simple structures that define a β‐strand conformation, a secondary structure that is central to peptide–protein interactions. For example, protease substrates and inhibitors almost universally adopt this geometry on active site binding. A planar pyrrole is used to replace two amino acids of a peptide backbone to generate a simple macrocycle that retains the required geometry for active site binding. The resulting β‐strand templates have reduced peptide character and provide potent protease inhibitors with the attachment of an appropriate amino aldehyde to the C‐terminus. Picomolar inhibitors of cathepsin L and S are reported and the mode of binding of one example to the model protease chymotrypsin is defined by X‐ray crystallography.     

Design and fabrication of subwavelength nanogratings based light-emitting diodes

Linearly polarized light from InGaN green light emitting diode grown on (0001) oriented sapphire is demonstrated by using subwavelength metallic nanogratings. Polarization ratio can reach 7:1 (∼88%), the highest ever reported from a single light emitting device. We discuss the design and fabrication of this device in detail.     

Supersymmetric right-handed s-b flavor mixing: implications of B(0)-->phiK(S) anomaly for B factories and colliders

Two recent experimental developments, when combined, may have far-reaching implications. S(phiK(S))<0, if confirmed, would imply large s-b mixing, a new CP phase, and right-handed dynamics. Large Deltam(B(s)) would be likely, making the B(s) program at hadron machines difficult. Reconstruction of B vertex from K(S) at B factories, as shown by BaBar's first measurement of SK(S)(pi(0)), makes SK(S)(pi(0)gamma) in B-->K(*0)gamma accessible. This would be a boon for B factory upgrades. Supersymmetric Abelian flavor symmetry, independently motivated, can realize all of this with a light sb(1) squark. B factory and collider studies of flavor, CP and supersymmetry, may not be what we had expected.     

Organic light‐emitting device dark spot growth behavior analysis by diffusion reaction theory

Dark spot growth rate tracing experiments performed on an organic light‐emitting device show that moisture entering into the device is relatively properly fitted by Fick's diffusion equation in the substrate/indium tin oxide (ITO)/hole transport layer (HTL)/silver (Ag) structure. It is believed that the moisture is dissolved into the polymer layer, which results in a decrease in the diffusion coefficient in the device with the substrate/ITO/HTL/electroluminescent (EL) polymer/Ag structure. The diffusion and chemical reaction occurring in the cathode layer further decreases the diffusion coefficient in the device with the substrate/ITO/HTL/EL polymer/calcium/Ag structure. Useful parameters, such as diffusion and solubility constants, describing possible mechanisms happening during dark spot growth on organic light‐emitting diode devices are extracted. © 2001 John Wiley & Sons, Inc. J Polym Sci Part B: Polym Phys 39: 1697–1703, 2001