Orlicz spaces for a family of measures

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Sulfanilamide-containing coordination compounds of Cu(II) with isatin and N-methylisatin thiosemicarbazones

Isatin (L¹) and N-methylisatin (L²) β-thiosemicarbazones react in ethanol with Cu(II) chloride and bromide in the presence of sulfanilamide (Streptocid, Sf¹), N-acetylsulfanilamide (Sulfacyl, Sf²), Norsulfazole (Sf³), Aethazolum (Sf⁴), and Sulfadimesine (Sf⁵) to form coordination compounds Cu(Sf^1–5)L^1–2X₂ · nH₂O (X = Cl, Br; n = 2–5). All the complexes have a monomeric structure. Thiosemicarbazones L¹ and L² in these complexes are tridentate O,N,S ligands, and sulfanilamides Sf^1–5 are monodentate ligands. Thermolysis of the substances involves the steps of dehydration (70–95°C) and complete decomposition (410–530°C).     

Donor—acceptor interactions of substituted benzenes with molecular chlorine and carbon disulfide

CNDO molecular orbital calculations have been performed to analyze donor—acceptor interactions between molecular chlorine and benzene, toluene, mesitylene and hexamethylbenzene and the, as yet, unreported chlorine—hexafluorobenzene and carbon disulfide—benzene pairs. The stabilization energy and the dipole moment and its derivative (?p/?R_CICI) calculated for the benzene—chlorine complex are in good agreement with the estimated experimental values. The trends in the experimental stabilization energies and the Cl-Cl vibrational frequencies with increasing methyl substitution appear to be well reproduced by the calculations. The charge transferred from the benzene donor is polarized toward the outer chlorine atom or sulfur atom. For hexafluorobenzene-chlorine the direction of electronic charge polarization is reversed from that of the benzene and methylbenzene complexes. The calculated results are discussed within the framework of Muliiken's simplified resonance theory for complexes.     

Synthesis and antifolate activity of 8,10-dideazaminopterin

A synthesis of 8,10-dideazaminopterin, using 2,4-diamino-6-bromomethyl-8-deazapteridine ( 2 ) as a key intermediate, is described. Condensation of the triphenylphosphinylide derived from 2 with p-formylbenzoyl-L-glutamate afforded a 9,10-dehydro-8,10-dideazaminopterin ester intermediate 5 . Hydrogenation of the olefinic linkage and subsequent hydrolysis of the glutamate ester gave the title compound. 8,10-Dideazaminopterin was a potent growth inhibitor of folate dependent bacteria. It was 16 times more potent then methotrexate as an inhibitor of dihydrofolate reductase derived from L1210 leukemia cells, and showed strong activity against L1210 in mice.     

The spectrophotometry and solvent-extraction behaviour of iron(III), vanadium(IV and V) and titanium(IV) chelates of 1-(o-carboxyphenyl)-3-hydroxy-3-methyltriazene

l-(o-Carboxyphenyl)-3-hydroxy-3-methyltriazene is proposed as an excellent reagent for the spectrophotometric determination of iron(III) and titanium(IV), and also for the separation of titanium from a large quantity of iron as well as other cations and anions. Iron(III) forms an anionic violet 1:2 complex at pH 4.0–9.4, and a cationic green 1:1 complex at pH 1.5–2.0, with absorption maxima at 570 nm and 660 nm, respectively. The violet complex is quantitatively extracted in chloroform containing n-octylamine at pH 3.0–9.0. The green and the violet iron(III) complexes obey Beer's law, the respective optimal ranges being 8.9–35.8 and 3.9–11.2 p.p.m. The yellow titanium chelate extracted into chloroform (absorption maximum at 410 nm) between pH 1.0 and 3.5, can be re-extracted into concentrated sulphuric acid a violet colour being produced with absorption maximum at 530 nm. Beer's law is obeyed in the ranges 0.8–5.7 p.p.m. for the titanium complex in chloroform and 3.4–19.2 p.p.m. when extracted in concentrated sulphuric acid. Interferences from diverse ions are not severe. Procedures for the separation and determination of titanium in the presence of a large quantity of iron are given. The isolation of the iron(III) and vanadium(IV and V) complexes, and their properties, are described.     

Highly efficient recycling of a "sandwich" type polyoxometalate oxidation catalyst using solvent resistant nanofiltration

A "sandwich" type polyoxometalate catalyst ([MeN(n-C8H17)3]12[WZn3(ZnW9O34)2]) was very efficiently recycled by nanofiltration with almost quantitative retention, using an alpha-alumina supported mesoporous gamma-alumina membrane.     

A one-pot synthesis of novel sugar derived 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones: an entry towards highly functionalized sugar-heterocyclic hybrids

An efficient and practical one-pot method for the synthesis of novel diversified sugar derived dihydro-quinazolino[4,3-b]quinazolin-8-ones has been reported. Various protected sugar hemiacetals were used to synthesize the hybrid tetracyclic ring system. The one-step reductive transformation of 2-(2-nitrophenyl)-3H-quinazolin-4-one with different sugar hemiacetals furnished the desired tetracyclic product in good yields and with high purity.     

Coordination chemistry of f-block elements with imine acids. Part IV. Synthetic and chiroptical studies on lanthanide(III) complexes of imine acids derived from L-alanine,L-valine,L-tyrosine and L-glutamic acid

Summary N-(orthovanillidene)L-alanine (OVAlaH₂), N-(salicylidene)L-valine (SValH₂), N-(orthovanillidene)L-valine (OVValH₂), N-(orthovanillidene)L-tyrosine (OVTyrH₃) and N-(salicylidene)L-glutamic acid (SGluH₃) react with La^III, Pr^III, Nd^III and Sm^III to yield new chiral complexes. Their dominant conformers were determined from c.d. spectra supported by¹H n.m.r. data, except for the L-glutamic acid derived complexes which were insoluble.     

Biyclo[2.2.1]heptane as cyclopentane precursor. Part 4 Stereocontrolled syhthesis of a potential intermediate to chromophycane dolastane and clavularane

The regio– and stereoselective synthesis of the keto-esters 20 and 22 are described, the latter being a potential intermediate to several diterpenes. The key steps involve the Diels-Alder cycloaddition between the benzocycloheptenone 5 and cyclopentadiene followed by a regioselective functionalisation of the adduct 6. A remarkable reversal of regioselectivity was observed during oxymercuration of the unsymmetric double bond in 6 and its reduced product 11 leading to 8 and 12 which were subsequently transformed to 20 and 22 respectively.     

Biomimetic studies on anti-thyroid drugs and thyroid hormone synthesis

The selenium analogues of anti-thyroid drugs exhibit their anti-thyroid action by a mechanism different from that of MMI. The selenium analogue of MMI and related selenium compounds exhibit high GPx activity, providing a novel method for the reversible inhibition of thyroid hormone biosynthesis.