Automated data processing of [1H-decoupled] 13C MR spectra acquired from human brain in vivo

In clinical 13C infusion studies, broadband excitation of 200 ppm of the human brain yields 13C MR spectra with a time resolution of 2-5 min and generates up to 2000 metabolite peaks over 2h. We describe a fast, automated, observer-independent technique for processing [1H-decoupled] 13C spectra. Quantified 13C spectroscopic signals, before and after the administration of [1-13C]glucose and/or [1-13C]acetate in human subjects are determined. Stepwise improvements of data processing are illustrated by examples of normal and pathological results. Variation in analysis of individual 13C resonances ranged between 2 and 14%. Using this method it is possible to reliably identify subtle metabolic effects of brain disease including Alzheimer's disease and epilepsy.     

Dennett on Free Will

Daniel Dennett maintains that regardless of determinism humans are both free to act and have a meaningful existence. Yet Dennett’s compatibilism entails that a felicity-advancing interaction with the world is all that we could wish for, which seems false. I also argue that Dennett’s attempt to define the terms central to this metaphysical debate fails. The weaknesses of Dennett’s case suggest that he is motivated more by his desire to complete the naturalistic project than he is by the pursuit of philosophical coherence.     

A phase regulated back wave propagation technique for geoacoustic inversion

An inversion method based on the concept of back wave propagation (BWP) is described in this paper for estimation of geoacoustic parameters from acoustic field data. A phase-regulation technique is introduced to increase the sensitivity of the method for geoacoustic model parameters having low sensitivity. The case of data consisting of signal plus additive noise is also addressed. It is shown theoretically that the sensitivity can be increased by a factor alpha using the phase regulation procedure, and that the spatial resolution of signal energy that is concentrated by BWP at the known source position is increased when a increases. This result suggests an effective criterion for use in the inversion, based on the spatial distribution of signal energy around the true source location. The basis for the criterion is the spatial variance of the back-propagated pressure field in a window around the known source location. A multistep search process is proposed to avoid using a complicated multidimensional search process. Inversion results from both simulations and experimental data are given. The real data were taken from the Pacific Shelf experiment carried out in shallow water off the West Coast of Vancouver Island in the Northeast Pacific Ocean.     

A novel piezo-optical styrene sensor incorporating polymer-supported tribromide ion

Encapsulation of Amberlyst A-26 supported tribromide in a 10,000 MW polyethylene glycol matrix gives a robust colour-sensitive reagent matrix which can be deposited on indium-tin oxide coated polyvinylidene fluoride (PVDF) piezoelectric film for the detection of styrene (and other alkene) vapours.     

Regioselective silylation of sugars through palladium nanoparticle-catalyzed silane alcoholysis

Palladium(0)-catalyzed silane alcoholysis was applied to sugars for the first time using tert-butyldimethylsilane (TBDMS-H) and Ph(3)SiH as the silanes. The catalyst is a colloidal solution of Pd(0) generated in situ from PdX(2) (X = Cl(-), OAc(-)) and TBDMS-H in N,N-dimethylacetamide. The colloid has been characterized by dynamic light scattering and transmission electron microscopy and consists of catalytically highly active nanoparticles of approximately 2 nm diameter. The silane alcoholysis reaction is an effective method for the regioselective silylation of methyl and phenyl glycosides and generates hydrogen gas as the only side product. For many of the sugar substrates investigated, the distribution of regioisomers obtained is complementary to that of the traditional R(3)SiCl/base (base = pyridine, imidazole) methodology and gives convenient access to the 3,6- rather than the 2,6-silylated pyranosides, obtained as the main product by the silyl chloride method. The method also allows a selective axial silylation of levoglucosan and 1,3,5-O-methylidene-myo-inositol. In an attempt to rationalize the observed regioselectivities, ab initio predictions (HF/3-21G) have been made on the relative energies of some of the silylated products. They suggest that the observed regioselectivities do not reflect a kinetic vs thermodynamic product distribution but are induced by the silylation agent employed. Models for the possible origin of the observed regioselectivity in both silylation methods (silane- and silyl chloride-based) are discussed.     

Extremely low vertical-emittance beam in the accelerator test facility at KEK

Electron beams with the lowest, normalized transverse emittance recorded so far were produced and confirmed in single-bunch-mode operation of the Accelerator Test Facility at KEK. We established a tuning method of the damping ring which achieves a small vertical dispersion and small x-y orbit coupling. The vertical emittance was less than 1% of the horizontal emittance. At the zero-intensity limit, the vertical normalized emittance was less than 2.8 x 10(-8) rad m at beam energy 1.3 GeV. At high intensity, strong effects of intrabeam scattering were observed, which had been expected in view of the extremely high particle density due to the small transverse emittance.     

A Hochschild Homology Euler Characteristic for Circle Actions

We define an S¹-Euler characteristic, _S ¹(X), of a circle action on a compact manifold or finite complex X. It lies in the first Hochschild homology group HH ₁(G) where G is the fundamental group of X. This _S ¹(X) is analogous in many ways to the ordinary Euler characteristic. One application is an intuitively satisfying formula for the Euler class (integer coefficients) of the normal bundle to a smooth circle action without fixed points on a manifold. In the special case of a three-dimensional Seifert fibered space, this formula is particularly effective.