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排序方式: 共有120条查询结果,搜索用时 31 毫秒
111.
Graeme Moad Katherine Dean Lex Edmond Natalia Kukaleva Guoxin Li Roshan T A Mayadunne Rudolf Pfaendner Armin Schneider George Simon Hendrik Wermter 《Macromolecular Symposia》2006,233(1):170-179
The use of various copolymers as dispersants/intercalants/exfoliants in polypropylene (PP)-clay nanocomposites based on unmodified montmorillonite clays (NaMMT) has been explored. The primary objective of this research has been to find dispersants that allow PP nanocomposites to be formed by direct melt mixing, that are effective with unmodified clays and that comprise only a minor component of the overall composition both with respect to both clay and PP. Two classes of dispersants were investigated: PEO-based nonionic surfactants and amphiphilic copolymers based on a long chain (meth)acrylate (e.g. octadecyl acrylate) and a more polar comonomer (e.g. maleic anhydride, N-vinylpyrrolidone, methyl methacrylate). The state of dispersion achieved and the properties of the derived nanocomposites were found to depend strongly on both on the level of dispersant and its overall composition but interestingly properties are not particularly dependent on the dispersant architecture (i.e. whether statistical, gradient or block copolymer). The nanocomposites possess a tensile modulus up to 40% greater that the precursor PP while elongation at break and impact strength are significantly improved over “clay alone” composites and reference organoclay-based nanocomposites. Also notable are significantly better thermal and thermo-oxidative stability as compared to both PP and “clay alone” composites. For optimal properties, it is both necessary and desirable that the surfactant should only be a minor constituent (20–50 wt-%) of the composition with respect to clay. 相似文献
112.
Roshan Ahmad Mohammad Zia-ul-Haq Shahid Hameed Humaira Akhtar Helmut Duddeck 《Monatshefte für Chemie / Chemical Monthly》2000,131(4):393-400
Summary. A convenient procedure is reported for the preparation of benzofuro-annelated 2-phenyl-1,5-benzothiazepine derivatives by
oxidative cyclocondensation of phenolic β-diketones with o-aminothiophenol in DMSO. The regiochemistry of these compounds is proven by HMBC signals and the existence of a five-bond 19F,13C-2 coupling. Surprisingly, treatment with LiAlH4 at room temperature led to a double reduction under opening of the five-membered ring. Refluxing such solutions with a higher
amount of LiAlH4 gave rise to a further reduced derivative possessing the trans-configuration. All structures (regio- and stereochemistry) were assigned on the basis of NMR spectroscopic data.
Received November 22, 1999. Accepted December 21, 1999 相似文献
113.
Schultz KC Supekova L Ryu Y Xie J Perera R Schultz PG 《Journal of the American Chemical Society》2006,128(43):13984-13985
An orthogonal tRNA/aminoacyl-tRNA synthetase pair has been evolved that makes it possible to selectively and efficiently incorporate para-cyanophenylalanine (pCNPhe) into proteins in E. coli at sites specified by the amber nonsense codon, TAG. Substitution of pCNPhe for histidine-64 in myoglobin (Mb) affords a sensitive vibrational probe of ligand binding. This methodology provides a useful infrared reporter of protein structure, biomolecular interactions, and conformational changes. 相似文献
114.
Negin Roshan Mohammad Reza Rahimpour 《Journal of Dispersion Science and Technology》2018,39(5):700-710
The main objective of this research is to determine the capability of four surface-active compounds namely poly(ethylene glycol) distearate, N,N-dimethyldodecylamine N–oxide solution, polyoxyethylene (10) tridecyl ether, and polyethylene glycol sorbitan monooleate as demulsifier agents in breaking water-in-crude oil emulsion through the bottle test method. The influence of temperature, concentration, water content, and pH on demulsification efficiency of the studied demulsifiers was investigated via the response surface methodology (RSM) and the central composite design method (CCD) was applied to design the experiments. The optimum values of input variables to obtain the maximum water separation efficiency were determined based on the developed model by analyze of variance (ANOVA). The R-squared values demonstrate that the developed models could appropriately predict the experimental results of all demulsifier agents. 相似文献
115.
Shekhar KC Roshan K. Dhungana Namrata Khanal Prof. Ramesh Giri 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(21):8124-8128
We report a Ni-catalyzed regioselective α-carbonylalkylarylation of vinylarenes with α-halocarbonyl compounds and arylzinc reagents. The reaction works with primary, secondary, and tertiary α-halocarbonyl molecules, and electronically varied arylzinc reagents. The reaction generates γ,γ-diarylcarbonyl derivatives with α-secondary, tertiary, and quaternary carbon centers. The products can be readily converted to aryltetralones, including a precursor to Zoloft, an antidepressant drug. 相似文献
116.
This work is motivated by a problem of optimizing printed circuit board manufacturing using design of experiments. The data are binary, which poses challenges in model fitting and optimization. We use the idea of failure amplification method to increase the information supplied by the data and then use a Bayesian approach for model fitting. The Bayesian approach is implemented using Gaussian process models on a latent variable representation. It is demonstrated that the failure amplification method coupled with a Bayesian approach is highly suitable for optimizing a process with binary data. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
117.
R. Taherzadeh Mousavian S. Sharafi M. R. Roshan M. H. Shariat 《Journal of Thermal Analysis and Calorimetry》2011,104(3):1063-1070
A powder mixture of Al/TiO2/H3BO3 = 10/3/6 in molar ratio was used in this study to form the Al2O3–TiB2 ceramic composite via thermite reactions (combustion synthesis). As no combustion synthesis occurred for an unmilled sample
in a furnace, the mixture was milled in a planetary ball-mill for various milling times, and the as-milled samples were in
situ synthesized in the furnace at a heating rate of 10 °C/min. The differential scanning calorimetry (DSC) measurements were
performed with the same heating rate on the unmilled and the as-milled samples to evaluate the influences of the milling on
the mechanisms and efficiencies of reactions. Although no combustion synthesis occurred for the unmilled sample in the furnace,
two exothermic peaks were detected in its DSC curve after the melting of the Al. For the as-milled samples, significant changes
revealed in the DSC curves, suggest that the milling process before the combustion synthesis changed the mechanisms and efficiencies
of reactions. In addition, the intensity and the temperature of the exothermic peaks in the DSC curves changed by increasing
the milling time. According to the XRD analyses, by enhancing the milling time, the purity of the final products would increase,
confirming that the efficiency of the reactions increased. Finally, the microstructures of the as-milled and as-synthesized
samples were examined by a SEM, and it was shown that the morphology of the reactant powders was altered by increasing the
milling time. 相似文献
118.
Stimulus-responsiveness and drug release from porous silicon films ATRP-grafted with poly(N-isopropylacrylamide) 总被引:1,自引:0,他引:1
Vasani RB McInnes SJ Cole MA Jani AM Ellis AV Voelcker NH 《Langmuir : the ACS journal of surfaces and colloids》2011,27(12):7843-7853
In this report, we employ surface-initiated atom transfer radical polymerization (SI-ATRP) to graft a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAM), of controlled thickness from porous silicon (pSi) films to produce a stimulus-responsive inorganic-organic composite material. The optical properties of this material are studied using interferometric reflectance spectroscopy (IRS) above and below the lower critical solution temperature (LCST) of the PNIPAM graft polymer with regard to variation of pore sizes and thickness of the pSi layer (using discrete samples and pSi gradients) and also the thickness of the PNIPAM coatings. Our investigations of the composite's thermal switching properties show that pore size, pSi layer thickness, and PNIPAM coating thickness critically influence the material's thermoresponsiveness. This composite material has considerable potential for a range of applications including temperature sensors and feedback controlled drug release. Indeed, we demonstrate that modulation of the temperature around the LCST significantly alters the rate of release of the fluorescent anticancer drug camptothecin from the pSi-PNIPAM composite films. 相似文献
119.
Roshan M. Borkar Abhinav Kanwal Bandu Raju Sai Sharanya Pulimamidi Agneesh Pratim Das Subhash Mohan Agarwal Sanjay K. Banerjee Ragampeta Srinivas 《Journal of mass spectrometry : JMS》2023,58(8):e4964
Phlorizin (PRZ) is a natural product that belongs to a class of dihydrochalcones. The unique pharmacological property of PRZ is to block glucose absorption or reabsorption through specific and competitive inhibitors of the sodium/glucose cotransporters (SGLTs) in the intestine (SGLT1) and kidney (SGLT2). This results in glycosuria by inhibiting renal reabsorption of glucose and can be used as an adjuvant treatment for type 2 diabetes. The pharmacokinetic profile, metabolites of the PRZ, and efficacy of metabolites towards SGLTs are unknown. Therefore, the present study on the characterization of hitherto unknown in vivo metabolites of PRZ and pharmacokinetic profiling using liquid chromatography-electrospray ionization tandem mass spectrometry (LC/ESI/MS/MS) and accurate mass measurements is undertaken. Plasma, urine, and feces samples were collected after oral administration of PRZ to Sprague–Dawley rats to identify in vivo metabolites. Furthermore, in silico efficacy of the identified metabolites was evaluated by docking study. PRZ at an intraperitoneal dose of 400 mg/kg showed maximum concentration in the blood to 439.32 ± 8.84 ng/mL at 1 h, while phloretin showed 14.38 ± 0.33 ng/mL at 6 h. The pharmacokinetic profile of PRZ showed that the maximum concentration lies between 1 and 2 h after dosing. Decreased blood glucose levels and maximum excretion of glucose in the urine were observed when the PRZ and metabolites were observed in plasma. The identification and characterization of PRZ metabolites by LC/ESI/MS/MS further revealed that the phase I metabolites of PRZ are hydroxy (mono-, di-, and tri-) and reduction. Phase II metabolites are O-methylated, O-acetylated, O-sulfated, and glucuronide metabolites of PRZ. Further docking study revealed that the metabolites diglucuronide metabolite of mono-hydroxylated PRZ and mono-glucuronidation of PRZ could be considered novel inhibitors of SGLT1 and SGLT2, respectively, which show better binding affinities than their parent compound PRZ and the known inhibitors. 相似文献
120.
Ezio Rizzardo John Chiefari Bill Y.K. Chong Frances Ercole Julia Krstina Justine Jeffery Tam P.T. Le Roshan T.A. Mayadunne Gordon F. Meijs Catherine L. Moad Graeme Moad San H. Thang 《Macromolecular Symposia》1999,143(1):291-307
This paper describes a versatile and effective method for the control of free radical polymerization and its use in the preparation of narrow polydispersity polymers of various architectures. Living character is conferred to conventional free radical polymerization by the addition of a thiocarbonylthio compound of general structure S=C(Z)SR, for example, S=C(Ph)SC(CH3)2Ph. The mechanism involves Reversible Addition-Fragmentation chain Transfer and, for convenience of referral, we have designated it the RAFT polymerization. The process is compatible with a very wide range of monomers including functional monomers such as acrylic acid, hydroxyethyl methacrylate, and dimethylaminoethyl methacrylate. Examples of narrow polydispersity (≤1.2) homopolymers, copolymers, gradient copolymers, end-functional polymers, star polymers, A-B diblock and A-B-A triblock copolymers are presented. 相似文献