全文获取类型
收费全文 | 127篇 |
免费 | 6篇 |
专业分类
化学 | 98篇 |
力学 | 1篇 |
数学 | 17篇 |
物理学 | 17篇 |
出版年
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 4篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 3篇 |
2017年 | 1篇 |
2016年 | 6篇 |
2015年 | 1篇 |
2014年 | 5篇 |
2013年 | 8篇 |
2012年 | 4篇 |
2011年 | 4篇 |
2010年 | 3篇 |
2009年 | 3篇 |
2008年 | 9篇 |
2007年 | 6篇 |
2006年 | 10篇 |
2005年 | 13篇 |
2004年 | 6篇 |
2003年 | 6篇 |
2002年 | 5篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1995年 | 2篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1982年 | 2篇 |
1979年 | 3篇 |
1976年 | 4篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1973年 | 2篇 |
排序方式: 共有133条查询结果,搜索用时 0 毫秒
31.
Agerdnio Andrade de Souza Brenda Lorena Snchez Ortíz Rosemary de Carvalho Rocha Koga Priscila Faimann Sales Divino Bruno da Cunha Ana Luiza Mantovaneli Guerra Gisele Custdio de Souza Jos Carlos Tavares Carvalho 《Molecules (Basel, Switzerland)》2021,26(24)
Plant-derived products may represent promising strategies in the treatment of Neglected Tropical Diseases (NTDs). From this perspective, it is observed that the Amazon phytogeographic region contains the tribe Canarieae of the Burseraceae family, composed of trees and shrubs supplied with resin channels. Its uses in folk medicine are related to aromatic properties, which have numerous medicinal applications and are present in reports from traditional peoples, sometimes as the only therapeutic resource. Despite its economic and pharmacological importance in the region, and although the family is distributed in all tropical and subtropical regions of the world, most of the scientific information available is limited to Asian and African species. Therefore, the present work aimed to review the secondary metabolites with possible pharmacological potential of the species Trattinnickia rhoifolia Willd, popularly known as “Breu sucuruba”. To this end, an identification key was created for chemical compounds with greater occurrence in the literature of the genus Trattinnickia. The most evident therapeutic activities in the consulted studies were antimicrobial, antioxidant, anti-inflammatory, antiviral, antifungal, anesthetic and antiparasitic. An expressive chemical and pharmacological relevance of the species was identified, although its potential is insufficiently explored, mainly in the face of the NTDs present in the Brazilian Amazon. 相似文献
32.
Rosemary J. Armstrong-Chong 《Tetrahedron》2004,60(45):10239-10244
Sequential treatment of ω-bromoalkyl triflates with an alkynyllithium at 0 °C followed by addition of a second alkynyllithium and NaI and heating the reaction mixture provides a simple one-pot access to unsymmetrical diynes in good yields. These diynes may be transformed stereoselectively into diene pheromones such as (Z,Z)- and (E,Z)-3,13-octadecadienyl acetate. 相似文献
33.
Yong Liu Mitchell D. Green Rosemary Marques Tony Pereira Roy Helmy R. Thomas Williamson Wolfgang Bermel Gary E. Martin 《Tetrahedron letters》2014
Difficulties in isolating samples from complex biological matrices and sensitivity limitations have long stymied the utilization of heteronuclear 2D NMR for the characterization of drug metabolites. Small diameter cryogenic NMR probes have largely ameliorated sensitivity limitations and the recently reported pure shift HSQC 2D NMR pulse sequence offers a further and marked improvement in both resolution and sensitivity. Using a 7.4 μg sample of the commercially available metabolite 3-hydroxy carbamazepine dissolved in 30 μL of deuterated solvent and a 600 MHz NMR equipped with a 1.7 mm cryogenic NMR probe, it was possible to acquire high signal-to-noise pure shift HSQC data in just over 30 min. A conventional HSQC spectrum acquired with identical parameters had approximately half the signal-to-noise of the pure shift HSQC spectrum. Collapsing the vicinal homonuclear couplings in the pure shift HSQC spectrum also significantly improves resolution. A practical, real world application of the technique is illustrated with the chromatographically isolated metabolite 3-hydroxy amiodarone from incubation with CYP2J2 recombinant enzyme. High quality pure shift HSQC data were recorded in slightly over 14 h for a 3 μg sample of the metabolite. 相似文献
34.
Dr. Wael E. Houssen Andrew F. Bent Dr. Andrew R. McEwan Nathalie Pieiller Dr. Jioji Tabudravu Dr. Jesko Koehnke Greg Mann Rosemary I. Adaba Dr. Louise Thomas Dr. Usama W. Hawas Dr. Huanting Liu Dr. Ulrich Schwarz‐Linek Prof. Margaret C. M. Smith Prof. James H. Naismith Prof. Marcel Jaspars 《Angewandte Chemie (International ed. in English)》2014,53(51):14171-14174
Heterocycle‐containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine‐derived enzymes and substrates obtained from a family of ribosomally produced and post‐translationally modified peptides called the cyanobactins. The substrate precursor peptide is engineered to have a non‐native protease cleavage site that can be rapidly cleaved. The other enzymes used are heterocyclases that convert Cys or Cys/Ser/Thr into their corresponding azolines. A macrocycle is formed using a macrocyclase enzyme, followed by oxidation of the azolines to azoles with a specific oxidase. The work is exemplified by the production of 17 macrocycles containing 6–9 residues representing 11 out of the 20 canonical amino acids. 相似文献
35.
Desrochers PJ LeLievre S Johnson RJ Lamb BT Phelps AL Cordes AW Gu W Cramer SP 《Inorganic chemistry》2003,42(24):7945-7950
A stable discrete nickel borohydride complex (Tp*NiBH(4) or Tp*NiBD(4)) was prepared using the nitrogen-donor ligand hydrotris(3,5-dimethylpyrazolyl)borate (Tp*-). This complex represents one of the best characterized nickel(II) borohydrides to date. Tp*NiBH(4) and Tp*NiBD(4) are stable toward air, boiling water, and high temperatures (mp > 230 degrees C dec). X-ray crystallographic measurements for Tp*NiBH(4) showed a six-coordinate geometry for the complex, with the nickel(II) center facially coordinated by three bridging hydrogen atoms from borohydride and a tridentate Tp(-) ligand. For Tp*NiBH(4), the empirical formula is C(15)H(26)B(2)N(6)Ni, a = 13.469(9) A, b = 7.740(1) A, c = 18.851(2) A, beta = 107.605(9) degrees, the space group is monoclinic P2(1)/c, and Z = 4. Infrared measurements confirmed the presence of bridging hydrogen atoms; both nu(B[bond]H)(terminal) and nu(B[bond]H)(bridging) are assignable and shifted relative to nu(B-D) of Tp*NiBD(4) by amounts in agreement with theory. Despite their hydrolytic stability, Tp*NiBH(4) and Tp*NiBD(4) readily reduce halocarbon substrates, leading to the complete series of Tp*NiX complexes (X = Cl, Br, I). These reactions showed a pronounced hydrogen/deuterium rate dependence (k(H)/k(D) approximately 3) and sharp isosbestic points in progressive electronic spectra. Nickel K-edge X-ray absorption spectroscopy (XAS) measurements of a hydride-rich nickel center were obtained for Tp*NiBH(4), Tp*NiBD(4), and Tp*NiCl. X-ray absorption near-edge spectroscopy results confirmed the similar six-coordinate geometries for Tp*NiBH(4) and Tp*NiBD(4). These contrasted with XAS results for the crystallographically characterized pseudotetrahedral Tp*NiCl complex. The stability of Tp*Ni-coordinated borohydride is significant given this ion's accelerated decomposition and hydrolysis in the presence of transition metals and simple metal salts. 相似文献
36.
37.
McCoy LF Scholl PF Schleicher RL Groopman JD Powers CD Pfeiffer CM 《Rapid communications in mass spectrometry : RCM》2005,19(16):2203-2210
A method for quantitative analysis of aflatoxin B1-lysine adduct (B1-Lys) in serum by liquid chromatography using tandem mass spectrometry (LC/MS/MS) is presented. The protein in a 250-microL sample was digested in the presence of a stable-isotope internal standard during a 4-h incubation at 37 degrees C with Pronasetrade mark. B1-Lys and the internal standard were extracted using mixed-mode solid-phase extraction cartridges and eluted with 2% formic acid in methanol. Following evaporation and reconstitution, extracts were injected onto a Luna C-18(2) column and eluted with a step gradient of acetonitrile and 0.06% formic acid. The B1-Lys and the internal standard were detected in a positive ionization selective reaction monitoring mode with a ThermoFinnigan TSQ Quantum triple quadrupole mass spectrometer. Calibration curves were linear for concentrations from 0.05-8.0 ng/mL. The method was validated with aflatoxin B1 dosed rat serum diluted to anticipated high and low concentrations. Total imprecision determined from 30 measurements over 15 days was 5.6% and 9.1%, respectively. Recoveries of 78.8 +/- 6.4% for B1-Lys and 85.4 +/- 12.4% for the internal standard were based on the full extraction and reconstitution processes. The method can be used to quantitate B1-Lys at the 0.5 pg/mg albumin level and is suitable for routine analysis. 相似文献
38.
A Counterion‐Directed Approach to the Diels–Alder Paradigm: Cascade Synthesis of Tricyclic Fused Cyclopropanes 下载免费PDF全文
Dr. Emily Kiss Dr. Craig D. Campbell Dr. Russell W. Driver John D. Jolliffe Rosemary Lang Dr. Tetiana Sergeieva Prof. Dr. Sergiy Okovytyy Prof. Dr. Robert S. Paton Prof. Dr. Martin D. Smith 《Angewandte Chemie (International ed. in English)》2016,55(44):13813-13817
An approach to the intramolecular Diels–Alder reaction has led to a cascade synthesis of complex carbocycles composed of three fused rings and up to five stereocenters with complete stereocontrol. Computational analysis reveals that the reaction proceeds by a Michael/Michael/cyclopropanation/epimerization cascade in which size and coordination of the counterion is key. 相似文献
39.
Rosemary Cogan Evans Curry Derald Walling 《International Journal of Mathematical Education in Science & Technology》2013,44(4):619-632
Virtually from its inception psychophysics has been caught on the horns of the dilemma as to the proper form of the fundamental psychophysical law. This paper illustrates an integration of two competing theories. 相似文献
40.
ABSTRACTClusters and shells based on icosahedral symmetry are characterised, constructed from component particles that retain memory of their neighbours in a specific reference structure. This memory provides the particles with ‘addressable’ characteristics, with a ground state corresponding to the structure where all the components are correctly addressed in terms of the local environment. The interparticle potentials have separate attractive and repulsive components, defined by the reference structure. For a single target structure, the relaxation efficiency is mostly determined by the variation of the attractive component for correctly and incorrectly addressed particles. The effects of varying the addressability can be visualised directly in terms of the underlying energy landscape, and follow quantitative predictions from catastrophe theory. A doubly-addressable landscape can be designed within the same framework. In well-defined regions of parameter space, the predicted global minima for aggregates of the target cluster (target monomer) form ‘superclusters’, which can be described in terms of multiple interacting copies of local minima for the monomer. The predicted lowest energy superclusters formed from aggregates of addressable icosahedral clusters and shells are themselves based on icosahedral packing. These hierarchical icosahedral structures could be realised experimentally if particles can be synthesised to match the interactions encoded in the addressable potentials. 相似文献