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991.
We construct a theory of distributions in the setting of analysis on post-critically finite self-similar fractals, and on
fractafolds and products based on such fractals. The results include basic properties of test functions and distributions,
a structure theorem showing that distributions are locally-finite sums of powers of the Laplacian applied to continuous functions,
and an analysis of the distributions with point support. Possible future applications to the study of hypoelliptic partial
differential operators are suggested. 相似文献
992.
A. Rogers 《Fresenius' Journal of Analytical Chemistry》1907,46(1):49-50
Ohne Zusammenfassung 相似文献
993.
C. D. Lowry Jr M. A. Smith G. B. Murphy E. W. J. Mardles H. Moss T. H. Rogers B. H. Shoemaker R. Heinze M. Marder A. Sippel und R. N. Donaldson 《Fresenius' Journal of Analytical Chemistry》1936,107(3-4):150-152
Ohne Zusammenfassung 相似文献
994.
Sumedh Kamble Peter Valtchev Aiken Dao Thophile Pelras Michael J Rogers Paul B. Savage Fariba Dehghani Aaron Schindeler 《Molecules (Basel, Switzerland)》2021,26(6)
Osteomyelitis and orthopedic infections are major clinical problems, limited by a lack of antibiotics specialized for such applications. In this paper, we describe the design and synthesis of a novel bone-binding antibiotic (BBA-1) and its subsequent structural and functional characterization. The synthesis of BBA-1 was the result of a two-step chemical conjugation of cationic selective antimicrobial-90 (CSA-90) and the bisphosphonate alendronate (ALN) via a heterobifunctional linker. This was analytically confirmed by HPLC, FT-IR, MS and NMR spectroscopy. BBA-1 showed rapid binding and high affinity to bone mineral in an in vitro hydroxyapatite binding assay. Kirby—Baur assays confirmed that BBA-1 shows a potent antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus comparable to CSA-90. Differentiation of cultured osteoblasts in media supplemented with BBA-1 led to increased alkaline phosphatase expression, which is consistent with the pro-osteogenic activity of CSA-90. Bisphosphonates, such as ALN, are inhibitors of protein prenylation, however, the amine conjugation of ALN to CSA-90 disrupted this activity in an in vitro protein prenylation assay. Overall, these findings support the antimicrobial, bone-binding, and pro-osteogenic activities of BBA-1. The compound and related agents have the potential to ensure lasting activity against osteomyelitis after systemic delivery. 相似文献
995.
Profiling of the secretome of human cancer cells: Preparation of supernatant for proteomic analysis 下载免费PDF全文
Linda Joanne Rogers Natalka Suchowerska Alamgir Khan Veronika Polaskova David Robert McKenzie 《Electrophoresis》2014,35(18):2626-2633
Secretomic analysis requires removal of serum proteins from cell‐culture media. We evaluate the proteins washed from cells prepared in bovine serum‐supplemented medium. PBS and serum‐free‐medium (SFM) were the washing solutions. A Bradford assay was used for total protein concentration and a 1D gel and LC‐MS/MS, to assign the protein to human or bovine origin. For both wash solutions, all bovine protein had been removed by the third wash, without compromising the number of living cells. Further washes reduced the number of living cells, especially when using PBS. Proteomic analysis of wash supernatant showed that SFM induced greater lysis of dead cells. Three washes were sufficient to minimize the effects on cell viability, while still removing serum proteins. Washing in SFM resulted in contamination of the wash supernatant with lysed dead cell proteins. Washed cells were incubated in SFM and exposed to ionizing radiation. Analysis of the supernatant showed an increase in human cytoplasmic, plasma membrane, and nuclear protein following irradiation. Secreted proteins were also detected, but in smaller quantities. The significance of these findings extend to in vitro studies of bystander phenomena, since the proteins of lysed dead cells may participate in driving bystander responses. 相似文献
996.
997.
Ionic liquid-in-oil microemulsions 总被引:5,自引:0,他引:5
Eastoe J Gold S Rogers SE Paul A Welton T Heenan RK Grillo I 《Journal of the American Chemical Society》2005,127(20):7302-7303
Phase stability and small-angle neutron scattering (SANS) data show that surfactant-stabilized nanodomains of a typical ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate [bmim][BF4]) may be dispersed by the nonionic surfactant Triton-X100 in cyclohexane. Analyses of these SANS data are consistent with the formation of ionic liquid-in-oil microemulsion droplets. 相似文献
998.
999.
A.R. Brajer T.E. Farley J.W. Kauffman L.K. Young R.J. Williams J.W. Rogers 《Analytica chimica acta》1977,91(2):165-173
Polarographic and spectrophotometric data show that tin(II) chloride is a weak electrolyte in dilute acetonitrile solutions. The dominant species, SnCl2, exists in a labile equilibrium with the ions SnCl+ and SnCl3- Oxidation and reduction of these ionic species is responsible for all observed polarographic plateaux. The dichloro—tin(II) molecule is shown to be a good acceptor species in acetonitrile solution, readily forming 1:1 complexes with ligands such as 4-picoline N-oxide. 相似文献
1000.
Complete structural characterization of dibenzo-18-crown-6·2 CH3NO2 and dibenzo-18-crown-6·2 CH3CN have been carried out, including location and refinement of the methyl hydrogen atoms. Dibenzo-18-crown-6·2 CH3NO2 is monoclinic,P21/c, with (at –150°C)a=9.573(2),b=14.636(2),c=33.471(7) Å, =93.77(2)°, andD
calc=1.37 g cm–3 forZ=8. Interactions between the solvent methyl groups and the crown ethers and other solvent nitro groups associate the 1 : 2 complexes into polymeric chains alongb. The acetonitrile adduct exists as discreet 1 : 2 complexes in the solid state with C–H...O interactions exlusively to the ether. This complex is triclinic,P 1, with (at –150°C)a=9.458(6),b=9.570(5),c=14.404(5) Å, =73.18(4), =79.85(5), =66.82(6)°, andD
calc=1.28 g cm–3 forZ=2.
Supplementary Data relating to this article are deposited with the British Library as Supplementary Publication No. SUP 82070 (22 pages).For part 4, see reference [1]. 相似文献