Ability of porous graphitic carbon to support electroosmotic flow in capillary electrochromatography

The existence of a cathodic EOF (electroosmotic flow) in the case of a porous graphitic carbon (PGC) partially packed column has been demonstrated. Then, the ability of PGC to afford electroosmosis has been brought to the fore with a fully PGC packed column. Experimental data have shown that PGC particles are negatively charged and their electrophoretic mobility has been evaluated. In order to investigate the conditions of existence of EOF different mobile phases have been tested. An EOF occurs when the conductivity of the PGC packed column is larger than the conductivity of an empty fused-silica capillary operating in the same conditions i.e. when the PGC participates in the electric conduction. Since the local electric fields in the two segments of the column are different, an evaluation of the electroosmotic mobility is not possible and the effect of the operational parameters such as the composition of the mobile phase (acetonitrile ratio and total ionic strength) has been studied in term of electroosmotic velocity V(eo).     

THE ENERGY ASPECT OF THE RECIPROCAL INTERACTIONS OF PAIRS OF TWO DIFFERENT VIBRATION MODES OF A CLAMPED ANNULAR PLATE

The standardized mutual active and reactive sound power of a clamped plate, representing the energy aspect of the reciprocal interactions of two different in vacuo modes, has been computed. It was assumed that the vibrations are axisymmetric, elastic and time harmonic, the plate's transverse deflection is small as compared with the plate's size, and that the vibration velocity is small as compared with the acoustic wavenumber generated. The Kirchhoff-Love theory of a perfectly elastic plate was used. The integral formulae for the mutual sound power were transformed into their Hankel representations which made possible their subsequent computation. A closed path integral was used to express the integral in its Hankel representation to compute the mutual active sound power. The asymptotic stationary phase method was used to compute the two magnitudes, i.e., the mutual active and reactive sound power. The results obtained are the asymptotic formulae valid for the acoustically fast waves. The oscillating as well as the non-oscillating terms have been identified in the formulae to make possible their further separate analysis. The availability of the asymptotic formulae makes possible some fast numerical computations of the mutual sound power. Moreover, the formulae presented herein, together with those for the individual modes known from the literature, make a complete basis for further computations of the total sound power of the plate's damped and forced vibrations in fluid.     

Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7

Mushrooms can be considered a valuable source of natural bioactive compounds with potential polypharmacological effects due to their proven antimicrobial, antiviral, antitumor, and antioxidant activities. In order to identify new potential anticancer compounds, an in-house chemical database of molecules extracted from both edible and non-edible fungal species was employed in a virtual screening against the isoform 7 of the Histone deacetylase (HDAC). This target is known to be implicated in different cancer processes, and in particular in both breast and ovarian tumors. In this work, we proposed the ibotenic acid as lead compound for the development of novel HDAC7 inhibitors, due to its antiproliferative activity in human breast cancer cells (MCF-7). These promising results represent the starting point for the discovery and the optimization of new HDAC7 inhibitors and highlight the interesting opportunity to apply the “drug repositioning” paradigm also to natural compounds deriving from mushrooms.     

Non-local temperature-dependent phase-field models for non-isothermal phase transitions

We propose a model for non-isothermal phase transitions withnon-con-served order parameter driven by a spatially non-localfree energy with respect to both the temperature and the orderparameter. The resulting system of equations is shown to bethermodynamically consistent and to admit a strong solution.     

History of Polymer Education-USA

Prior to 1940 there was little or no education directed toward polymer chemistry. With the contributions of Carothers and others that transformed the practice of polymers into a science-and the leadership of Herman Mark and others in formal graduate and postgraduate education-polymer education took root but rapid expansion and general acceptance by more traditionally oriented academic institutions was slowed by many barriers. Only since 1974 has there been a concerted effort to include education in the basic concepts of polymer chemistry into the undergraduate curriculum. Emphasis is on the development of polymer education in the United States.     

The fractionary Schrödinger equation,Green functions and ultradistributions

In this work, we generalize previous results about the Fractionary Schrödinger Equation within the formalism of the theory of Tempered Ultradistributions. Several examples of the use of this theory are given. In particular we evaluate the Green function for a free particle in the general case, for an arbitrary order of the derivative index.