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151.
We explored the potential of an emerging laser-based technology, photoacoustic imaging (PAI), for bladder cancer diagnosis through high-resolution imaging of microvasculature in the bladder tissues. Imaging results from ex vivo canine bladders demonstrated the excellent ability of PAI in mapping three-dimensional microvasculature in optically scattering bladder tissues. By comparing the results from human bladder specimens affected by cancer to those from the normal control, the feasibility of PAI to differentiate malignant from benign bladder tissues was also explored. The distinctive morphometric characteristics of tumor microvasculature can be seen in the images from cancer samples, suggesting that PAI may allow in vivo assessment of neoangiogenesis that is closely associated with bladder cancer generation and progression. By presenting subsurface morphological and physiological information in bladder tissues, PAI, when performed in a similar way as in conventional endoscopy, provides an opportunity for improved diagnosis, staging, and treatment guidance of bladder cancer. 相似文献
152.
Flávio B. Gonçalves Gareth O. Roberts 《Methodology and Computing in Applied Probability》2014,16(4):907-930
Exact simulation of SDEs is a very important and challenging problem. In this paper we discuss exact simulation problems for jump-diffusion processes. Motivated by statistical applications, our main contribution is to propose an algorithm that performs exact simulation of a class of jump-diffusion bridges. We also present and discuss the existing methods for forward simulation and propose an extension of one of them to account for unbounded jump rate. Finally, the exact algorithms are compared to competing non-exact ones in some simulated examples. 相似文献
153.
In a previous paper the authors, together with Balwant Singh, introduced an elementwisc characterization of weak subintegrality for an extension A?B of commutative rings. In the present paper we improve our methods for working with this characterization. This leads us to propose two new types of “elementary weakly subintegral extension”. 相似文献
154.
Intercalation-induced changes in DNA supercoiling observed in real-time by atomic force microscopy 总被引:1,自引:0,他引:1
L. H. Pope M. C. Davies C. A. Laughton C. J. Roberts S. J. B. Tendler P. M. Williams 《Analytica chimica acta》1999,400(1-3):27-32
Atomic force microscopy (AFM) has been employed to observe in real-time and in an aqueous environment the process of ethidium bromide induced supercoiling in individual DNA plasmid molecules. Image data reveal both the onset and the progressive presence of plectonemic DNA supercoiling. In addition, significant molecular motion of the surface adsorbed DNA is observed. These data illustrate the potential of AFM in the time-resolved study of biomolecular processes, and hence, provide new insights into biomolecular structure and function. 相似文献
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Stephen G. Davies Ai M. Fletcher Gesine J. Hermann Giovanna Poce Paul M. Roberts Andrew D. Smith Miles J. Sweet James E. Thomson 《Tetrahedron: Asymmetry》2010,21(13-14):1635-1648
The doubly diastereoselective conjugate addition of the antipodes of lithium N-benzyl-N-(α-methylbenzyl)amide to a range of enantiopure N-enoyl oxazolidin-2-ones has been used as a mechanistic probe to determine that the reactive conformation is the anti-s-cis form. The β-amino carbonyl products resulting from these conjugate addition reactions are useful templates for further elaboration into an α,β,α-pseudotripeptide. 相似文献
158.
Using the approach of Rulla (1996 SIAM J. Numer. Anal. 33, 68-87)for analysing the time discretization error and assuming moreregularity on the initial data, we improve on the error boundderived by Barrett and Blowey (1996 IMA J. Numer. Anal. 16,257-287) for a fully practical piecewise linear finite elementapproximation with a backward Euler time discretization of amodel for phase separation of a multi-component alloy. 相似文献
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W. L. Roberts K. P. Link T. M. Stevenson und J. S. Clayton 《Fresenius' Journal of Analytical Chemistry》1943,125(5-6):238-240
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