全文获取类型
收费全文 | 32436篇 |
免费 | 1083篇 |
国内免费 | 30篇 |
专业分类
化学 | 22204篇 |
晶体学 | 232篇 |
力学 | 601篇 |
数学 | 4549篇 |
物理学 | 5963篇 |
出版年
2023年 | 269篇 |
2022年 | 228篇 |
2021年 | 399篇 |
2020年 | 562篇 |
2019年 | 506篇 |
2018年 | 704篇 |
2017年 | 658篇 |
2016年 | 1256篇 |
2015年 | 1014篇 |
2014年 | 1024篇 |
2013年 | 2155篇 |
2012年 | 2374篇 |
2011年 | 2530篇 |
2010年 | 1438篇 |
2009年 | 1152篇 |
2008年 | 2088篇 |
2007年 | 2058篇 |
2006年 | 1804篇 |
2005年 | 1600篇 |
2004年 | 1313篇 |
2003年 | 1023篇 |
2002年 | 904篇 |
2001年 | 668篇 |
2000年 | 565篇 |
1999年 | 435篇 |
1998年 | 303篇 |
1997年 | 220篇 |
1996年 | 342篇 |
1995年 | 235篇 |
1994年 | 224篇 |
1993年 | 269篇 |
1992年 | 244篇 |
1991年 | 160篇 |
1990年 | 143篇 |
1989年 | 130篇 |
1988年 | 123篇 |
1987年 | 124篇 |
1986年 | 118篇 |
1985年 | 185篇 |
1984年 | 157篇 |
1983年 | 130篇 |
1982年 | 111篇 |
1981年 | 106篇 |
1980年 | 76篇 |
1979年 | 96篇 |
1978年 | 86篇 |
1977年 | 75篇 |
1976年 | 78篇 |
1975年 | 75篇 |
1973年 | 84篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Xiangfeng Luan Dr. Cristina Martín Pengfei Zhang Qian Li Dr. Isabella Anna Vacchi Prof. Lucia Gemma Delogu Prof. Yiyong Mai Dr. Alberto Bianco 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(42):18673-18679
As an emerging member of the graphene family, structurally defined graphene nanoribbons (GNRs) have shown promising applications in various fields. The evaluation of the degradability of GNRs is particularly important for assessing the persistence level and risk of these materials in living organisms and the environment. However, there is a void in the study of the degradation of GNRs. Here, we report the degradation behavior of GNRs in the presence of human myeloperoxidase (hMPO) or treated with the photo-Fenton (PF) reaction. With the assistance of potassium hydroxide or imidazole, which facilitates the dispersion of GNRs in the aqueous solution, GNRs underwent only partial degradation after 25-hour incubation with hMPO, while, the PF reaction degraded GNRs almost completely after 120 hours. These results indicate that structurally precise GNRs can be efficiently degraded under suitable conditions, providing more opportunities for future applications in different fields. 相似文献
992.
Tingting Ye Dr. Zifu Zhong Prof. Dr. Adolfo García-Sastre Prof. Dr. Michael Schotsaert Prof. Bruno G. De Geest 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(43):19045-19057
The current COVID-19 pandemic has a tremendous impact on daily life world-wide. Despite the ability to dampen the spread of SARS-CoV-2, the causative agent of the diseases, through restrictive interventions, it is believed that only effective vaccines will provide sufficient control over the disease and revert societal live back to normal. At present, a double-digit number of efforts are devoted to the development of a vaccine against COVID-19. Here, we provide an overview of these (pre)clinical efforts and provide background information on the technologies behind these vaccines. In addition, we discuss potential hurdles that need to be addressed prior to mass scale clinical translation of successful vaccine candidates. 相似文献
993.
Oleksandr Romanenko Petr Slepička Petr Malinsky Mariapompea Cutroneo Vladimír Havránek James Stammers Václav Švorčík Anna Macková 《Surface and interface analysis : SIA》2020,52(12):1040-1044
3D microstructures in pure poly(dimethylsiloxane) (PDMS) and PDMS with embedded Au nanoparticles were prepared by ion beam lithography without any further etching. Two mega-electron volts helium and 10 MeV oxygen ions were used for ion microstructuring. Parallel lines of 1 mm in length and 10 μm in thickness were fabricated for investigation of the effect of the nanoparticles presence in the polymer on the surface morphology of the created microstructures. The created microstructures were checked by optical microscope. Infrared (IR) spectrometry was used to study the effect of the ions type and fluence on the chemical changes of the material. Atomic force microscopy was used for the fine detail study as well as for checking the microstructure quality. Analysis revealed an increased radiation resistance of the nanocomposite compared to the pure PDMS. Shrinkage is proportional to the fluence, but the maximum value for both materials is limited by saturation. 3D microstructure in modified PDMS obtained at the same irradiation condition as pure PDMS is characterized by its smaller height. Obtaining the microstructure in nanocomposite of the same height as in pure PDMS by increasing the fluence can be impossible due to saturation of shrinkage and/or radiation-induced heating of the material. 相似文献
994.
Tiago Augusto Donegatti Alnilan Lobato Eliana A. R. Duek Luís Moreira Gonçalves Elisabete Alves Pereira 《Electrophoresis》2020,41(18-19):1576-1583
Aminoglycosides are a relevant class of antibiotics widely used by medics and veterinaries. There are a variety of reasons that make their determination relevant, such as quality control, environment and food contamination assessment, drug-release studies, among others. The lack of a chromophore makes aminoglycoside spectrophotometric detection particularly challenging, often requiring derivatization. In this work, an indirect detection method, making use of imidazole as a probe, applying CZE was successfully tested. It did not require derivatization, which simplified the sample preparation. Suitable figures of merit were obtained; recoveries between 95 and 105%, adequate repeatability and precision, correlation coefficients (r) above 0.998, and limits of detection (LODs) of 3.2 and 11 mg/L for gentamicin and paromomycin, respectively. As a proof-of-concept, it was also applied in a simple controlled release experiment that was well fitted using the Hill equation. 相似文献
995.
César R. García-Jacas Yovani Marrero-Ponce Ricardo Vivas-Reyes José Suárez-Lezcano Felix Martinez-Rios Julio E. Terán Longendri Aguilera-Mendoza 《Journal of computational chemistry》2020,41(12):1209-1227
Advances to the distributed, multi-core and fully cross-platform QuBiLS-MIDAS software v2.0 ( http://tomocomd.com/qubils-midas ) are reported in this article since the v1.0 release. The QuBiLS-MIDAS software is the only one that computes atom-pair and alignment-free geometrical MDs (3D-MDs) from several distance metrics other than the Euclidean distance, as well as alignment-free 3D-MDs that codify structural information regarding the relations among three and four atoms of a molecule. The most recent features added to the QuBiLS-MIDAS software v2.0 are related (a) to the calculation of atomic weightings from indices based on the vertex-degree invariant (e.g., Alikhanidi index); (b) to consider central chirality during the molecular encoding; (c) to use measures based on clustering methods and statistical functions to codify structural information among more than two atoms; (d) to the use of a novel method based on fuzzy membership functions to spherically truncate inter-atomic relations; and (e) to the use of weighted and fuzzy aggregation operators to compute global 3D-MDs according to the importance and/or interrelation of the atoms of a molecule during the molecular encoding. Moreover, a novel module to compute QuBiLS-MIDAS 3D-MDs from their headings was also developed. This module can be used either by the graphical user interface or by means of the software library. By using the library, both the predictive models built with the QuBiLS-MIDAS 3D-MDs and the QuBiLS-MIDAS 3D-MDs calculation can be embedded in other tools. A set of predefined QuBiLS-MIDAS 3D-MDs with high information content and low redundancy on a set comprised of 20,469 compounds is also provided to be employed in further cheminformatics tasks. This set of predefined 3D-MDs evidenced better performance than all the universe of Dragon (v5.5) and PaDEL 0D-to-3D MDs in variability studies, whereas a linear independence study proved that these QuBiLS-MIDAS 3D-MDs codify chemical information orthogonal to the Dragon 0D-to-3D MDs. This set of predefined 3D-MDs would be periodically updated as long as new results be achieved. In general, this report highlights our continued efforts to provide a better tool for a most suitable characterization of compounds, and in this way, to contribute to obtaining better outcomes in future applications. 相似文献
996.
Jennifer Paola Hernández Mancera Francisco Núñez-Zarur Soledad Gutiérrez-Oliva Alejandro Toro-Labbé Ricardo Vivas-Reyes 《Journal of computational chemistry》2020,41(23):2022-2032
Quantum chemical calculations were used to study the mechanism of Diels-Alder reactions involving chiral anthracenes as dienes and a series of dienophiles. The reaction force analysis was employed to obtain a detailed scrutiny of the reaction mechanisms, it has been found that thermodynamics and kinetics of the reactions are quite consistent: the lower the activation energy, the lower the reaction energy, thus following the Bell-Evans-Polanyi principle. It has been found that activation energies are mostly due to structural rearrangements that in most cases represented more than 70% of the activation energy. Electronic activity mostly due to changes in σ and π bonding were revealed by the reaction electronic flux (REF), this property helps identify whether changes on σ or π bonding drive the reaction. Additionally, new global indexes describing the behavior of the electronic activity were introduced and then used to classify the reactions in terms of the spontaneity of their electronic activity. Local natural bond order electronic population analysis was used to check consistency with global REF through the characterization of specific changes in the electronic density that might be responsible for the activity already detected by the REF. Results show that reactions involving acetoxy lactones are driven by spontaneous electronic activity coming from bond forming/strengthening processes; in the case of maleic anhydrides and maleimides it appears that both spontaneous and non-spontaneous electronic activity are quite active in driving the reactions. 相似文献
997.
Víctor Manuel Castor-Villegas José Manuel Guevara-Vela Wilmer E. Vallejo Narváez Ángel Martín Pendás Tomás Rocha-Rinza Alberto Fernández-Alarcón 《Journal of computational chemistry》2020,41(26):2266-2277
Hydrogen bonds (HB) are arguably the most important noncovalent interactions in chemistry. We study herein how differences in connectivity alter the strength of HBs within water clusters of different sizes. We used for this purpose the interacting quantum atoms energy partition, which allows for the quantification of HB formation energies within a molecular cluster. We could expand our previously reported hierarchy of HB strength in these systems (Phys. Chem. Chem. Phys., 2016, 18 , 19557) to include tetracoordinated monomers. Surprisingly, the HBs between tetracoordinated water molecules are not the strongest HBs despite the widespread occurrence of these motifs (e.g., in ice Ih). The strongest HBs within H2O clusters involve tricoordinated monomers. Nonetheless, HB tetracoordination is preferred in large water clusters because (a) it reduces HB anticooperativity associated with double HB donors and acceptors and (b) it results in a larger number of favorable interactions in the system. Finally, we also discuss (a) the importance of exchange-correlation to discriminate among the different examined types of HBs within H2O clusters, (b) the use of the above-mentioned scale to quickly assess the relative stability of different isomers of a given water cluster, and (c) how the findings of this research can be exploited to indagate about the formation of polymorphs in crystallography. Overall, we expect that this investigation will provide valuable insights into the subtle interplay of tri- and tetracoordination in HB donors and acceptors as well as the ensuing interaction energies within H2O clusters. 相似文献
998.
Daniel Hernández-Valdés Ricardo Fernández-Terán Benjamin Probst Bernhard Spingler Roger Alberto 《Helvetica chimica acta》2020,103(10):e2000147
Reduction of CO2 to CO and H2O is a two electron/two proton process. For this process, multinuclear complexes offer advantages by concentrating reduction equivalents more efficiently than mononuclear systems. We present novel complexes with [Re(η6-C6H6)2]+ as scaffold conjugated to one or two catalytically active [Ru(dmbpy)(CO)2Cl2] subunits (dmbpy=5,5′-dimethyl-2,2′-bipyridine). The [Re(η6-C6H6)2]+ scaffold was chosen due to its very high photo- and chemical stability, as well as the multiple degrees of freedom it offers for any conjugated functionalities. High efficiency and selectivity for the reduction of CO2 to CO (over H2 or HCOOH) is reported. TONs and TOFs were found to be comparable or higher than for the catalyst subunit without the rhenium framework. Cooperativity in photo- and electrocatalysis is observed for the complex comprising two catalytic subunits. The synergistic communication between the two catalytic subunits is responsible for the observed enhancement in both photo- and electrocatalytic performance. Confirmation of electronic communication between the two [Ru(dmbpy)(CO)2Cl2] subunits as well as the elucidation of a possible mechanism was supported by electrochemistry, IR-spectroelectrochemistry and DFT studies. 相似文献
999.
Víctor Sánchez Marlon Rodrigues Garcia Michelle Barreto Requena Renan Arnon Romano Leonardo de Boni Francisco E. G. Guimarães Sebastião Pratavieira 《Photochemistry and photobiology》2020,96(6):1208-1214
Photodynamic procedures have been used in many applications, ranging from cancer treatment to microorganism inactivation. Photodynamic reactions start with the activation of a photosensitizing molecule with light, leading to the production of cytotoxic molecules that promote cell death. However, establishing the correct light and photosensitizer dosimetry for a broadband light source remains challenging. In this study, we proposed a theoretical mathematical model for the photodegradation of protoporphyrin IX (PpIX), when irradiated by multi-wavelength light sources. The theoretical model predicts the experimental photobleaching (temporal change in PpIX concentration) of PpIX for different light sources. We showed that photobleaching occurs independently of the light source wavelengths but instead depends only on the number of absorbed photons. The model presented here can be used as an important mathematical approach to better understand current photodynamic therapy protocols and help achieve optimization of the doses delivered. 相似文献
1000.
Álvaro Dávila García Sylvain Bernès Fernando Sartillo-Piscil Rosa Luisa Meza-León 《Journal of heterocyclic chemistry》2020,57(12):4373-4379
The enantiopure synthesis of a truncated tetradenolide is presented. Starting from the versatile Chiron 7,3-lactone-xylofuranose derivative (7,3-LXF), the enantiomerically pure synthesis of the title compound is obtained in six steps with a 40% overall yield. 相似文献