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31.
Measuring the efficiency of decision making units 总被引:32,自引:0,他引:32
A nonlinear (nonconvex) programming model provides a new definition of efficiency for use in evaluating activities of not-for-profit entities participating in public programs. A scalar measure of the efficiency of each participating unit is thereby provided, along with methods for objectively determining weights by reference to the observational data for the multiple outputs and multiple inputs that characterize such programs. Equivalences are established to ordinary linear programming models for effecting computations. The duals to these linear programming models provide a new way for estimating extremal relations from observational data. Connections between engineering and economic approaches to efficiency are delineated along with new interpretations and ways of using them in evaluating and controlling managerial behavior in public programs. 相似文献
32.
33.
Nazikian R Berk HL Budny RV Burrell KH Doyle EJ Fonck RJ Gorelenkov NN Holcomb C Kramer GJ Jayakumar RJ La Haye RJ McKee GR Makowski MA Peebles WA Rhodes TL Solomon WM Strait EJ Vanzeeland MA Zeng L 《Physical review letters》2006,96(10):105006
Evidence is presented for a multitude of discrete frequency Alfvén waves in the core of magnetically confined high-temperature fusion plasmas. Multiple diagnostic instruments confirm wave excitation over a wide spatial range from the device size at the longest wavelengths down to the thermal ion Larmor radius. At the shortest scales, the poloidal wavelengths are comparable to the scale length of electrostatic drift wave turbulence. Theoretical analysis confirms a dominant interaction of the modes with particles in the thermal ion distribution traveling well below the Alfvén velocity. 相似文献
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35.
We are concerned with homogenization of stochastic differential equations (SDE) with stationary coefficients driven by Poisson random measures and Brownian motions in the critical case, that is, when the limiting equation admits both a Brownian part as well as a pure jump part. We state an annealed convergence theorem. This problem is deeply connected with homogenization of integral partial differential equations. 相似文献
36.
Schmitz L White AE Carter TA Peebles WA Rhodes TL Burrell KH Solomon W Staebler GM 《Physical review letters》2008,100(3):035002
Core electron-temperature fluctuations [0.5%< or =T[over ]_(e)/T_(e)< or =2%, k_(theta)rho_(s)< or =0.3 in neutral-beam-heated low confinement-mode (L-mode) plasmas] are observed to decrease by at least a factor of 4 in standard and quiescent high-confinement-mode (H-mode and QH-mode) regimes in the DIII-D tokamak (r/a=0.7). These fluctuations are attributed to ion temperature gradient (ITG) modes stabilized by rotational shear at the H-mode transition. The simultaneous reduction in electron heat diffusivity (chi_(e)(QH)/chi_(e)(L)<0.25) suggests that T[over ]_(e) fluctuations can contribute significantly to L-mode electron heat transport. 相似文献
37.
Christopher P. Gordon Neal Dalton Nicholas Vandegraaff John Deadman David I. Rhodes Jonathan A. Coates Stephen G. Pyne Renate Griffith John B. Bremner Paul A. Keller 《Tetrahedron》2018,74(12):1253-1268
As of mid-2017, only one structure of the human immunodeficiency virus (HIV) integrase core domain co-crystallised with an active site inhibitor was reported. In this structure (1QS4), integrase is complexed with a diketo-acid based strand-transfer inhibitor (INSTI). This structure has been a preferred platform for the structure-based design of INSTIs despite concerns relating to structural irregularities arising from crystallographic packing effects. A survey of the current pool of 297 reported integrase catalytic core structures indicated that the anatomy of the active site in the complex structure 1QS4 exhibits subtle variations relative to all other structures examined. Consequently, the 1QS4 structure was employed for docking studies. From the docking of twenty-seven allyltyrosine analogues, a 3-point inhibitor binding motif required for activity was established and successfully utilised in the development of a tripeptide displaying an EC50 value of 10 ± 5 μM in HIV infected human T-cells. Additional docking of “in-house” compound libraries unearthed a methyl ester based nitrile derivative displaying an IC50 value of 0.5 μM in a combined 3′-processing and strand-transfer assay. 相似文献
38.
Timothy P. Boyle Jonathan Coates Paul A. Keller Stephen G. Pyne David I. Rhodes 《Tetrahedron》2008,64(49):11270-11290
As part of a program investigating cyclic peptides with an internal aromatic hydrophobic scaffold as potential novel anti-bacterial agents, we explored the synthesis of simple tyrosine-based systems. These were prepared via key intermediates containing internal allylglycine and allyltyrosine residues for subsequent ring-closing metathesis reactions. Although the resulting anti-bacterial activity against Staphylococcus aureus was modest, this represents a novel and simple route to this class of compounds. One intermediate acyclic dipeptide precursor showed good activity against S. aureus with an MIC of 7.8 μg/mL. 相似文献
39.
François David Antti Kupiainen Rémi Rhodes Vincent Vargas 《Communications in Mathematical Physics》2016,342(3):869-907
In this paper, we rigorously construct Liouville Quantum Field Theory on the Riemann sphere introduced in the 1981 seminal work by Polyakov. We establish some of its fundamental properties like conformal covariance under PSL\({_2(\mathbb{C})}\)-action, Seiberg bounds, KPZ scaling laws, KPZ formula and the Weyl anomaly formula. We also make precise conjectures about the relationship of the theory to scaling limits of random planar maps conformally embedded onto the sphere. 相似文献
40.
The luminescence properties of NaCl are discussed. Attention is focussed predominantly upon the optically stimulated luminescence (OSL) signal (UV emission) of NaCl (420–560 nm stimulation). The results from experiments relevant to geological dating applications, such as signal resetting, dose response and thermal stability, are described. The behaviour of the OSL signal observed was found to be favourable for dating, with both the thermal stability and dose response suggesting a range of at least 10 ka. Signal resetting via optical exposure was found to be extremely rapid and no evidence of either thermoluminescence or OSL signals was found following re-crystallization. The potential for dating natural salt deposits, as found in various arid environments, appears to be good. 相似文献