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101.
Altland K Benson MD Costello CE Ferlini A Hazenberg BP Hund E Kristen AV Linke RP Merlini G Salvi F Saraiva MJ Singer R Skinner M Winter P 《Electrophoresis》2007,28(12):2053-2064
Mutations of the human transthyretin (TTR) gene have attracted medical interest as a cause of amyloidosis. Recently, we have described in detail an electrophoretic procedure with PAGE followed by IEF in urea gradients for the study of the microheterogeneity of TTR monomers (Altland, K., Winter, P., Sauerborn, M. K., Electrophoresis 1999, 20, 1349-1364). In this paper, we present a study on 49 different mutations of TTR including 33 that result in electrically neutral amino acid substitutions. The aims of the investigation were to test the sensitivity of the procedure to detect TTR variants in patients with TTR amyloidosis and their relatives and to identify some common characteristics that could explain the amyloidogenicity of these variants. We found that all tested amyloidogenic mutations could be detected by our method with the exception of those for which the corresponding variant was absent in plasma samples. Most of the electrically neutral amyloidogenic TTR variants had in common a reduced conformational stability of monomers by the activity of protons and urea. For three variants, e.g. TTR-F64L, TTR-I107V and TTR-V122I, the monomers had a conformational stability close to that of normal monomers but we found experimental and structural arguments for a weakening of the monomer-monomer contact. All types of amyloidogenic mutations affected the stability of TTR tetramers. 相似文献
102.
The article illustrates the advantages of partitioning the total electron density rho(rb), its Laplacian (inverted Delta)2 rho(rb), and the energy density H(rb) in terms of orbital components. By calculating the contributions of the mathematically constructed molecular orbitals to the measurable electron density, it is possible to quantify the bonding or antibonding character of each MO. This strategy is exploited to review the controversial existence of direct Fe-Fe bonding in the triply bridged Fe2(CO)9 system. Although the bond is predicted by electron counting rules, the interaction between the two pseudo-octahedral metal centers can be repulsive because of their fully occupied t(2g) sets. Moreover, previous atoms in molecules (AIM) studies failed to show a Fe-Fe bond critical point (bcp). The present electron density orbital partitioning (EDOP) analysis shows that one sigma bonding combination of the t(2g) levels is not totally overcome by the corresponding sigma* MO, which is partially delocalized over the bridging carbonyls. This suggests the existence of some, albeit weak, direct Fe-Fe bonding. 相似文献
103.
The neutral heteroleptic hexacoordinate silicon(IV) complexes 4 and 5 (SiO(6) skeletons) and the neutral pentacoordinate silicon(IV) complexes 7-9 (SiO(4)N skeletons) were synthesized, starting from the hexacoordinate precursor 2 and the pentacoordinate precursor 6, respectively. In these reactions, two monoanionic cyanato-N ligands are replaced by one dianionic bidentate O,O-chelate ligand. Compounds 4, 5, and 7-9 were characterized by single-crystal X-ray diffraction and solid-state and solution NMR spectroscopy. The chiral silicon(IV) complexes 4, 5, 7, and 8 were obtained as racemic mixtures, whereas 9 was isolated as a cocrystallizate consisting of the two diastereomers, (C,S)-9 and (A,S)-9 (ratio 1:1). The stereodynamics of 5 and 8 were studied by variable-temperature (1)H NMR experiments. 相似文献
104.
Rameshwar Adhikari Matthias Buschnakowski Sven Henning Sylvia Goerlitz Trinh An Huy Werner Lebek Reinhold Godehardt Georg Hannes Michler Ralf Lach Kalman Geiger Konrad Knoll 《Macromolecular rapid communications》2004,25(5):653-658
Summary: The morphology and tensile deformation behaviour of a highly asymmetric styrene/butadiene star block copolymer (polystyrene (PS) content = 74%) containing random PS‐co‐PB (polybutadiene) copolymer as a rubbery phase were investigated. The existence of double yielding, similar to that observed in some semicrystalline polymers, was detected in this nanostructured amorphous polymer. The observed phenomenon may be correlated with two different micromechanical processes taking place at the initial stage of deformation.
105.
Approximation of Metric Spaces by Partial Metric Spaces 总被引:1,自引:0,他引:1
Reinhold Heckmann 《Applied Categorical Structures》1999,7(1-2):71-83
Partial metrics are generalised metrics with non-zero self-distances. We slightly generalise Matthews' original definition of partial metrics, yielding a notion of weak partial metric. After considering weak partial metric spaces in general, we introduce a weak partial metric on the poset of formal balls of a metric space. This weak partial metric can be used to construct the completion of classical metric spaces from the domain-theoretic rounded ideal completion. 相似文献
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110.
Reinhold Tacke 《Angewandte Chemie (International ed. in English)》1999,38(20):3015-3018
6.7 Gigatonnes of silicon are processed each year by marine organisms. Since it was known that silicon is an essential element for many biological systems, significant advances in the biochemistry of this element have been achieved from the classical viewpoint of silicon being a purely inorganic element. This article describes the proteins, genes, and molecular mechanisms of silicon metabolism in diatoms and sponges. These studies may help to reveal the role of silicon for optimal development and growth in many plants and animals as well as initiate the development of new technological methods for the shape-controlled production of new patterned silicone-based materials. 相似文献