Charged particle multiplicity distributions ine + e − annihilation at 29 GeV: a comparison with hadronic data

The charged particle multiplicity distributions for two-jet events ine ⁺ e ^? annihilation at 29 GeV have been measured using the High Resolution Spectrometer at PEP. A Poisson distribution describes the data for both the complete event and for the single jets. In addition, no correlation is observed between the multiplicities in the two jets of an event. For fixed values of the prong number of the complete event, the multiplicity sharing between the two jets is in good agreement with a binomial distribution. The rapidity gap distribution is exponential with a slope equal to the mean rapidity density. These observations, which are consistent with a picture of independent emission of single particles, are contrasted to the results from soft hadronic collisions and conclusions are drawn about the nature of clusters.     

An expression for transient thermal stress in a nonhomogeneous plate with temperature variation through thickness

Summary An expression for nonzero thermal stress in a nonhomogeneous flat plate with arbitrary variation in mechanical properties is presented under a transient temperature distribution. Especially an equation for nonzero thermal stress and its numerical calculation showing the effect of nonhomogeneous thermal and mechanical properties on temperature and thermal stress distribution, is given for the case of an exponentially varying thermal conductivity and Young's modulus, but for a homogeneous Poisson's ratio and coefficient of linear thermal expansion.

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Formeln für transiente Wärmespannungen in einer nichthomogenen Platte mit einer über die Dicke veränderlichen Temperatur

Übersicht Es werden Ausdrücke für nichtverschwindende Wärmespannungen in einer inhomogenen ebenen Platte bei beliebiger Ortsabhängigkeit der mechanischen Eigenschaften entwickelt, und zwar für eine transiente Temperaturverteilung. Insbesondere wird eine Gleichung für nichtverschwindende Wärmespannungen angegeben und numerisch ausgewertet, die den Einfluß nichthomogener thermischer und mechanischer Eigenschaften auf die Verteilung von Temperatur und Wärmespannung bei exponentieller Ortsabhängigkeit der Wärmeleitfähigkeit und des E-Moduls darstellt, wobei jedoch die Poissonzahl und der lineare Wärmeausdehnungskoeffizient konstant sind.

     

One-dimensional regular isotropic heisenberg antiferromagnetism in an organic radical p-diethylaminophenyl nitronyl nitroxide [DEAPNN]: Observation of spin-flop at high field

The magnetic properties of the organic radical p-diethylaminophenyl nitronyl nitroxide (DEAPNN; 2-(4'-diethylaminophenyl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxy-3-N-oxide) have been investigated. The magnetization isotherms of DEAPNN measured up to 20.5 T at 1.7 and 4.2 K show a spin-flop phenomenon characteristic of one-dimensional regular isotropic Heisenberg antiferromagnetism. The magnetic susceptibility of DEAPNN is well interpreted by the Heisenberg antiferromagnetism in the whole temperature range of 2–300 K. The exchange coupling constant is determined to be J/k = -2.45 K based on the spin Hamiltonian H = -2JΣS_iS_{i + 1}.     

Triangle contraction in six-membered-ring silicon clusters

We propose the “triangle contraction” as an important reconstruction mechanism of six-membered-ring silicon clusters on the basis of the force and virial analysis for Si₆, Si₁₀, Si₁₄, Si₁₈, Si₂₂, and Si₂₆ clusters. Forces acting on atoms have been calculated using the local-density-functional scheme with linear-combination-of-atomic-orbitals-Xα method. Calculated forces show that most of the (111)-surface equilateral triangles have tendency to contract, indicating the generality of the triangle-contraction mechanism.     

Neutral K1(890) and ρ0 meson production in e+e− annihilation at ;s=29GeV

The production of neutral K¹(890) and ρ⁰ mesons was studied in e⁺e^? annihilation at $\text{s}\text{=29}\text{GeV}$ using the High Resolution Spectrometer at PEP. Differential cross sections are presented as a function of the scaled energy variable z and compared to π⁰ and K⁰ production. The measured multiplicities are 0.84±0.08 ?⁰ mesons and $\text{0.57±0.09 K}{}^{10}\text{(890)}$ mesons per event for a meson momentum greater than 725 MeV/c. The ratios of vector meson to pseudoscalar meson production for (u,d), s and c quark are compared to predictions of the Lund model.     

Synthesis and evaluation of 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydrobenzofuran-2-carboxylic acid ethyl ester derivatives as potent antitumor agents

For the construction of new combinatorial libraries, a lead compound was created by replacing the core structure of a hit compound discovered by screening for cytotoxic agents against a tumorigenic cell line. The newly designed compound maintained biological activity and allowed alternative library construction for antitumor drugs.     

Supervised scoring models with docked ligand conformations for structure-based virtual screening

Protein-ligand docking programs have been used to efficiently discover novel ligands for target proteins from large-scale compound databases. However, better scoring methods are needed. Generally, scoring functions are optimized by means of various techniques that affect their fitness for reproducing X-ray structures and protein-ligand binding affinities. However, these scoring functions do not always work well for all target proteins. A scoring function should be optimized for a target protein to enhance enrichment for structure-based virtual screening. To address this problem, we propose the supervised scoring model (SSM), which takes into account the protein-ligand binding process using docked ligand conformations with supervised learning for optimizing scoring functions against a target protein. SSM employs a rough linear correlation between binding free energy and the root mean square deviation of a native ligand for predicting binding energy. We applied SSM to the FlexX scoring function, that is, F-Score, with five different target proteins: thymidine kinase (TK), estrogen receptor (ER), acetylcholine esterase (AChE), phosphodiesterase 5 (PDE5), and peroxisome proliferator-activated receptor gamma (PPARgamma). For these five proteins, SSM always enhanced enrichment better than F-Score, exhibiting superior performance that was particularly remarkable for TK, AChE, and PPARgamma. We also demonstrated that SSM is especially good at enhancing enrichments of the top ranks of screened compounds, which is useful in practical drug screening.     

siRNA-mediated Knockdown of the Heme Synthesis and Degradation Pathways: Modulation of Treatment Effect of 5-Aminolevulinic Acid-based Photodynamic Therapy in Urothelial Cancer Cell Lines

Photodynamic therapy mediated by 5-aminolevulinic acid (ALA-PDT) has been developed as a therapeutic modality for refractory superficial bladder cancers. Here, in experiments using urothelial cancer cell lines, we investigated the effects of siRNA modulating heme-synthetic and degradation pathways for ALA-PDT. Targeted knockdown of ferrochelatase (FECH) suppressed heme synthesis and significantly increased intracellular protoporphyrin IX (PpIX) accumulation, leading to enhanced phototoxicity in four of five cell lines. Heme oxygenase-1 (HO-1) is recognized as important for cytoprotection against oxidative stress such as PDT. Targeted knockdown of HO-1 leads to decreased intracellular PpIX accumulation, resulting in a failure to enhance ALA-PDT effect in four cell lines. Knockdown of HO-1 caused marked growth inhibition in UM-UC-2 overexpressing HO-1, whereas no inhibitory effect was observed in UM-UC-3 lacking HO-1 expression. Moreover, HO-1 protein levels and (GT) _n repeat polymorphism of the HO-1 gene promoter region were examined with the implication that the constitutive expressions of HO-1 protein were associated with a shorter (GT) _n repeat. Our results suggested that (1) FECH siRNA improved the phototoxicity of ALA-PDT, (2) overexpression of HO-1 was associated with shorter (GT) _n repeat of the promoter region, and (3) siRNA-mediated knockdown of HO-1 could suppress the growth of bladder cancer cells overexpressing HO-1.