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51.
Jayesh G. Panchal Ravindra V. Patel Shobhana K. Menon 《Journal of inclusion phenomena and macrocyclic chemistry》2010,67(1-2):201-208
The formation of inclusion complexes with para-sulfonated calix[n]arene (PSC[n]A) was studied for carbamazepine (CBMZ), a poorly water soluble anticonvulsant drug. The effect of PSC[4]A and PSC[6]A on aqueous solubility of carbamazepine was studied extensively. The complete complexation of the drug was achieved after 48 h of shaking with PSC[n]A in water and evaporation of water to get solid complex. The interaction between PSC[n]A and CBMZ in solid state inclusion complexes was accomplished by aqueous phase solubility studies, HPLC, DSC, PXRD, FTIR, UV–Vis, and FT-Raman spectroscopy. The solubility of CBMZ increases as a function of PSC[n]A concentration. The results of the two phase solubility experiments are in good conformity to signify the formation of 1:1 (PSC[6]A:CBMZ) and 2:1 PSC[4]A:CBMZ complexes. The order of dissolution rate of CBMZ is inclusion complex > physical mixture > drug alone. The purpose of this study was to enhance solubility resulting in high dissolution rate and bioavailability of this essentially water insoluble drug. 相似文献
52.
Despite biological variability the spectral characteristics of undiluted human urine show relatively low autofluorescence at short UV (250-300 nm) excitation. However with dilution the fluorescence intensity remarkably increases. This paper examines the mechanisms behind this effect, by using excitation-emission matrices. Corrections for the inner filter effect were made for improved understanding of the spectral patterns. We focused on three major fluorophores (tryptophan, indoxyl sulfate and 5-hydroxyindole-3-acetate) that are excited at these wavelengths, and whose content in urine is strongly linked with various health conditions. Their fluorescence was studied both individually and in combinations. We also examined the effect of ammonium on the fluorescence of these major fluorophores individually and in combinations. Through these studies we have identified the leading effects that reduce the UV fluorescence, namely higher concentration of indoxyl sulfate producing the inner filter effect and concentration quenching and quenching of fluorophores by ammonium. This result will assist in broader utilisation of UV fluorescence in medical diagnostics. 相似文献
53.
Ravindra V. Patel Jayesh G. Panchal V. A. Rana Shobhana K. Menon 《Journal of inclusion phenomena and macrocyclic chemistry》2010,66(3-4):285-295
New liquid crystals based on calix[4]arene Schiff base were prepared by the reaction of tetraamino-calix[4]arene with aldehydes (4-hydroxy benzaldehyde, 2-vanillin, 4-vanillin and 2-hydroxy naphthaldehyde). Dielectric investigations on a magnetically oriented sample forming N, SmA, and SmC phases were carried out. The dielectric constant (ε’ and ε”) and dielectric loss (tan δ) have been determined as a function of frequency (20 Hz–2 MHz). The synthesized derivatives were purified and characterized by FT-IR, 1H-NMR, 13C-NMR and MALDI-TOF MS. All the synthesized compounds were investigated for liquid crystalline properties using DSC (Differential Scanning Calorimetry), DTA (Differential Thermal Analysis) and POM (Polarizing Optical Microscopy) attached with a hot stage. They generally exhibited nematic and typical fanlike or mosaic texture, which suggest the ordered smectic mesophases. Compounds were found to adopt a specific molecular structure due to the rigid bowl like calix[4]arene core, i.e., a cone-like structure with mesogenic units aligned within the molecule. 相似文献
54.
A. S. Menon 《Colloid and polymer science》1937,78(3):272-277
Ohne Zusammenfassung
übersetzt von A. Siehr (Leipzig).
Herrn Prof. H. E. Watson, D. Sc., F. I. C., M. I. Chem. E., m?chte ich an dieser Stelle meinen herzlichsten Dank für seine
wertvolle Hilfe und Anleitung bei der Durchführung dieser Arbeit aussprechen. 相似文献
55.
Twenty three at‐risk high school female students who had failed mathematics and science in a traditional school setting were the subjects of this study that integrated mathematics and science lessons over a period of four weeks. Using a combination of direct instruction, calculations, graphing, hands‐on projects, and discussion, the topic of mechanical advantage was studied, to find out how well students understood the topic. The study found that these students who initially knew very little about mechanical advantage, and who did not see any need to use mathematics in the study of science, indicated an increased understanding of mechanical advantage, and also seemed to realize that integrating mathematics and science enhanced learning. 相似文献
56.
P. Kesava Menon 《Proceedings Mathematical Sciences》1943,17(4):107-113
57.
K.R. Rajesh Shaji Varghese C.S. Menon 《Journal of Physics and Chemistry of Solids》2007,68(4):556-560
A Schottky structure is fabricated using CuPc sandwiched between fluorinated tin oxide (FTO) and aluminium electrodes. The electrical properties of the device are measured at room temperature. Permittivity of the device is calculated from capacitance measurements. The saturation current density, , diode ideality factor, n=3.02 and barrier height, are determined for the Schottky juction. Reverse bias versus is interpreted in terms of Schottky emission. Solar cell parameters are determined from the J-V characteristics. Power conversion efficiency, η of 0.0024% is obtained for the cell. Band gap energy of the material is determined from UV-visible absorption spectrum. 相似文献
58.
Sarah A. Shepherd Chinnan Karthikeyan Jonathan Latham Anna-Winona Struck Mark L. Thompson Binuraj R. K. Menon Matthew Q. Styles Colin Levy David Leys Jason Micklefield 《Chemical science》2015,6(6):3454-3460
Flavin-dependent halogenases are potentially valuable biocatalysts for the regioselective halogenation of aromatic compounds. These enzymes, utilising benign inorganic halides, offer potential advantages over traditional non-enzymatic halogenation chemistry that often lacks regiocontrol and requires deleterious reagents. Here we extend the biocatalytic repertoire of the tryptophan halogenases, demonstrating how these enzymes can halogenate a range of alternative aryl substrates. Using structure guided mutagenesis we also show that it is possible to alter the regioselectivity as well as increase the activity of the halogenases with non-native substrates including anthranilic acid; an important intermediate in the synthesis and biosynthesis of pharmaceuticals and other valuable products. 相似文献
59.
Shobhana K. Menon Nishith R. Modi Bhoomika Mistry Kuldeep Joshi 《Journal of inclusion phenomena and macrocyclic chemistry》2011,71(1-2):121-127
As a part of our investigations to unfold the chemistry of calixresorcinarene, we have focused on the formation of inclusion complex of a poorly soluble (43 μg ml?1 at pH 7) drug mycophenolate mofetil (MMF) an immunosuppressive agent and an inosine monophosphate dehydrogenase (IMPDH) inhibitor with para sulphonatocalix[4]resorcinarene (PSC4R). The complete complexation of the drug was achieved after 48 h of stirring with para sulphonatocalix[4]resorcinarene(PSC[4]R) in water and evaporation of water yield the solid complex. The interaction between para sulphonatocalix[4]resorcinarene(PSC[4]R) and MMF in solid state inclusion complexes was accomplished by aqueous phase solubility studies, Thermal Analysis, HPLC, PXRD, FT-IR, and UV–Vis spectroscopy. The results of the phase solubility experiments are in good conformity to signify the formation of 2:1 PSC4R: MMF complexes. The purpose of this study was to enhance solubility and resulting in high dissolution rate and bioavailability of this essentially water insoluble drug. The results of the in vivo study shows that there is a remarkable change in the toxicity of the pure drug MMF and complex did not produce any mortality up to 2200 mg kg?1. 相似文献
60.
The single- and multi-mode Richtmyer–Meshkov instabilities (RMI) with reshock are numerically analyzed in two- and three-dimensional
domains. Four different types of air/SF
6 interface shapes are investigated in a shock tube configuration, and the predicted post-reshock growth rates are compared
with available empirical models of Mikaelian’s (Physica D 36(3):343–347, 1989) and Charakhch’an’s (J Appl Mech Tech Phys 41(1):23–31, 2000). The simulation of 3D multi-mode RMI shows good agreement with a past experimental study, but other interface types (2D
single-mode, 2D multi-mode and 3D single-mode) result in different growth rates after reshock. Parametric studies are therefore
performed to investigate the sensitivities of the post-reshock growth rates to model the empirical parameters. For single-mode
RMI configurations, the interface shape is found to be only a weak function of the post-reshock growth rate, as also predicted
by previous reshock models. The post-reshock growth rate shows a linear correlation to the velocity jump due to reshock; however,
it is only about a half of the prediction of Charakhch’an’s model even though the growth before reshock compares well with
pre-reshock models. The 3D single-mode post-reshock RMI growth rate is nearly 1.6 times larger than the 2D single-mode RMI.
The parametric studies of multi-mode RMI show two distinctly different growth rates depending on the mixing conditions at
reshock. If the interface remains sharp at the time of reshock, the post-reshock growth rate is as large as the single-mode
cases. However, if the interface is mixed due to non-linear interactions of bubbles and spikes, the growth rates becomes slow
and independent of the interface shapes. Overall, this study provides new insights into the flow features of reshocked RMI
for different initial perturbation types. 相似文献