CuBe precipitation in Cu-Be alloys

The decomposition of supersaturated, disordered, solid solutions in the binary Cu-2 wt % Be and the ternary Cu-2 wt % Be-0.6 wt % Co alloys was found to be initiated through the formation of GP zones. The ordered CuBe phase (B2 structure) was found to form from these clusters by continuous ordering. The morphology, the crystallography and the mechanism of formation of the precipitate phase is discussed in this paper.     

Synthesis and mesomorphic characterization of azoesters with a coumarin ring

We have synthesized a homologous series of azoesters consisting of a coumaryl moiety as the end group. Eleven derivatives of this series exhibit mesomorphism. The nematic mesophase is exhibited from ethyl homologue onward, while the smectic phase commences at the pentyl derivative and is exhibited along with the nematic phase up to the hexadecyl derivative. The N-I transition temperatures curves show the usual odd-even effect. All the compounds in this series are thermally stable and exhibit a wide mesomorphic range of nearly 120°C. Their thermal stabilities and other characteristics are discussed.     

Large Eddy Simulation of a Free-Burning Arc Discharge in Argon with a Turbulent Cross Flow and External Field

In most of the numerical approaches proposed for modeling high-intensity plasma-arcs, the effects of turbulence on the arc structure are often excluded because of the intricate physics originating from the interaction of turbulent scales, high-temperature gas dynamics, magnetohydrodynamics (MHD) and chemical kinetics. The goal of this study is threefold: to develop a generic turbulent MHD model to simulate free-burning arc discharges, to validate the code with available experimental data, and to investigate the effect of an external field and turbulent cross flow on the free-burning arc configuration. The governing equations are solved in conservative form using a hybrid scheme that combines a high-order monotonic upwind scheme with a second-order central scheme. The fluid and MHD turbulence are resolved using a large eddy simulation (LES) approach with a recently developed sub-grid closure model. An implicit scheme is used to compute the magnetic diffusion term appearing in the magnetic induction equation to alleviate the severe time-step constraint. The comparison of the model prediction with experimental data for Argon arcs at different current intensities shows generally good agreement. When an external field is applied, the overall shape of the free-burning arc drastically changes. The straightening of the arc indicates the potential for stabilization of a free-burning arc by magnetic forces. Even though the turbulence is significantly attenuated as a result of the thermal expansion near the cathode, it adds an unsteady characteristic to the arc and, in general, has a negative impact on the stabilization of the electrical discharge.     

Electron diffraction studies of variable periodicity in decagonal quasicrystals in aluminium-cobalt alloys

The reciprocal space vectors of the decagonal phase can be generated by a slight distortion of the basis vectors of a regular icosahedron to induce commensuration in one dimension. In different alloys a multiple of this basic periodicity has been observed. In particular, in Al-Co alloys, apart from the basic periodicity, doubling, tripling and quadrupling of this basic underlying periodicity has been observed. Stereographic analysis, simulation and experimental observation of electron diffraction patterns have been used to explore the nature of this varying periodicity in detail.     

Simulation techniques for predicting current and voltage distribution across electrode surface and electrolyte

Journal of Solid State Electrochemistry - One of the prerequisites in all electrochemical processes is to achieve uniform distribution in potential and current across the electrodes and the cell....     

A High-Performance Thin-Layer Chromatographic Method for the Evaluation of Marmelosin from Aegle marmelos Corr. Extract and Its Traditional Formulation from Rat Plasma: Application to Pharmacokinetics

JPC – Journal of Planar Chromatography – Modern TLC - Marmelosin is one of the major phytochemical constituents of Aegle marmelos (L.) Corr. (Rutaceae). Till date, there are no methods...     

Simultaneous quantitation of rosuvastatin and gemfibrozil in human plasma by high-performance liquid chromatography and its application to a pharmacokinetic study

A simple, sensitive and specific high-performance liquid chromatography method is described for simultaneous determination of rosuvastatin (RST) and gemfibrozil (GFZ) in human plasma using celecoxib as an internal standard (IS). The assay procedure involved extraction of RST, GFZ and IS from plasma into acetonitrile. Following separation and evaporation of the organic layer the residue was reconstituted in the mobile phase and injected onto an X-Terra C(18) column (4.6 x 150 mm, 5.0 microm). The chromatographic run time was less than 20 min using flow gradient (0.0-1.60 mL/min) with a mobile phase consisting of 0.01 M ammonium acetate:acetonitrile:methanol (50:40:10, v/v/v) and UV detection at 275 nm. Nominal retention times of RST, GFZ and IS were 6.7, 13.9 and 16.4 min, respectively. Absolute recovery of both analytes and IS was greater than 90%. The lower limit of quantification (LLOQ) of RST and GFZ was 0.03 and 0.30 microg/mL, respectively. Linearity was excellent (r(2) = 0.999) in the 0.03-10 microg/mL and 0.3-100 microg/mL ranges for RST and GFZ, respectively. The inter- and intra-day precisions in the measurement of RST quality control (QC) samples 0.03, 0.09, 2.50 and 8.00 microg/mL were in the range 2.37-9.78% relative standard deviation (RSD) and 0.92-10.08% RSD, respectively. Similarly, the inter- and intra-day precisions in the measurement of GFZ quality control (QC) samples 0.30, 0.90, 25.0 and 80.0 microg/mL were in the ranges 2.79-6.27 and 0.96-9.69% RSD, respectively. Accuracies in the measurement of QC samples for RST and GFZ were in the range 85.43-107.23 and 84.98-102.35% respectively, of the nominal values. RST and GFZ were stable in the array of stability studies viz., bench-top, auto-sampler and freeze-thaw cycles. Stability of RST and GFZ was established for 1 month at -80C. The application of the assay in an oral pharmacokinetic study in rats co-administered with RST and GFZ is described.