Some Cohen–Macaulay and Unmixed Binomial Edge Ideals

We study unmixed and Cohen-Macaulay properties of the binomial edge ideal of some classes of graphs. We compute the depth of the binomial edge ideal of a generalized block graph. We also characterize all generalized block graphs whose binomial edge ideals are Cohen–Macaulay and unmixed. So that we generalize the results of Ene, Herzog, and Hibi on block graphs. Moreover, we study unmixedness and Cohen–Macaulayness of the binomial edge ideal of some graph products such as the join and corona of two graphs with respect to the original graphs.     

On the coupling of the homotopy perturbation method and Laplace transformation

In this paper, a Laplace homotopy perturbation method is employed for solving one-dimensional non-homogeneous partial differential equations with a variable coefficient. This method is a combination of the Laplace transform and the Homotopy Perturbation Method (LHPM). LHPM presents an accurate methodology to solve non-homogeneous partial differential equations with a variable coefficient. The aim of using the Laplace transform is to overcome the deficiency that is mainly caused by unsatisfied conditions in other semi-analytical methods such as HPM, VIM, and ADM. The approximate solutions obtained by means of LHPM in a wide range of the problem’s domain were compared with those results obtained from the actual solutions, the Homotopy Perturbation Method (HPM) and the finite element method. The comparison shows a precise agreement between the results, and introduces this new method as an applicable one which it needs fewer computations and is much easier and more convenient than others, so it can be widely used in engineering too.     

Composition operators acting on Besov spaces on the real line

We study the composition operator \(T_f(g):= f\circ g\) on Besov spaces \(B_{{p},{q}}^{s}(\mathbb{R })\) . In case \(1 < p< +\infty ,\, 0< q \le +\infty \) and \(s>1+ (1/p)\) , we will prove that the operator \(T_f\) maps \(B_{{p},{q}}^{s}(\mathbb{R })\) to itself if, and only if, \(f(0)=0\) and \(f\) belongs locally to \(B_{{p},{q}}^{s}(\mathbb{R })\) . For the case \(p=q\) , i.e., in case of Slobodeckij spaces, we can extend our results from the real line to \(\mathbb{R }^n\) .     

Le problème de Yamabe avec singularités

Let (Mn,g) be a compact riemannian manifold of dimension n?3. Under some assumptions, we prove that there exists a positive function φ solution of the Yamabe equation

     

SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development

Chemokines and their receptors play important roles in numerous physiological and pathological processes. To develop natural chemokines into receptor probes and inhibitors of pathological processes, the lack of chemokine-receptor selectivity must be overcome. Here, we apply chemical synthesis and the concept of modular modifications to generate unnatural synthetically and modularly modified (SMM)-chemokines that have high receptor selectivity and affinity, and reduced toxicity. A proof of the concept was shown by transforming the nonselective viral macrophage inflammatory protein-II into new analogs with enhanced selectivity and potency for CXCR4 or CCR5, two principal coreceptors for human immunodeficiency virus (HIV)-1 entry. These new analogs provided insights into receptor binding and signaling mechanisms and acted as potent HIV-1 inhibitors. These results support the concept of SMM-chemokines for studying and controlling the function of other chemokine receptors.