Hüseyin Sari  Esin Kasapoglu  Serpil Sakiroglu  Ismail Skmen  Carlos A. Duque 《physica status solidi b》2019,256(8)

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Ruqi Chen  Jun Xu  Meimei Lao  Zhiwei Liang  Yukai Chen  Chujie Zhong  Linjun Huang  Aize Hao  Muhammad Ismail 《固体物理学:研究快报》2019,13(11)

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Hamid Reza Bakhsheshi‐Rad  Xiongbiao Chen  Ahmad Fauzi Ismail  Madzlan Aziz  Elaheh Abdolahi  Fereshteh Mahmoodiyan 《先进技术聚合物》2019,30(5):1333-1339

Bacteria‐caused infection remains an issue in the treatment of bone defects by means of Mg‐Zn‐Ca alloy implants. This study aimed to improve the antibacterial properties of an Mg‐Zn‐Ca alloy by coating with chitosan‐based nanofibers with incorporated silver sulfadiazine (AgSD) and multiwall carbon nanotubes (MWCNTs). AgSD and MWCNTs were prepared at a weight ratio of 1:1 and then added to chitosan at varying concentrations (ie, 0, 0.25, 0.5, and 1.5 wt.%) to form composites. The obtained composites were ejected in nanofiber form using an electrospinning technique and coated on the surface of an Mg‐Zn‐Ca alloy to improve its antibacterial properties. A microstructural examination by scanning electron microscopy (SEM) revealed the diameter of chitosan nanofiber ejected increased with the concentration of AgSD‐MWCNTs. The incorporation of AgSD‐MWCNTs into the chitosan nanofibers was confirmed by Fourier transform infrared spectroscopy (FTIR). Examination of the antibacterial activity shows that chitosan nanofibers with AgSD‐MWCNTs can significantly inhibit the growth and infiltration of Escherichia coli and Staphylococcus aureus. Biocompatibility assay and cell morphology observations demonstrate that AgSD‐MWCNTs incorporated into nanofibers are cytocompatible. Taken together, the results of this study demonstrate the potential application of electrospun chitosan with AgSD‐MWCNTs as an antibacterial coating on Mg‐Zn‐Ca alloy implants for bone treatment.  相似文献   

    

K. Z. Elwakeel  A. A. El-Bindary  A. Ismail  A. M. Morshidy 《Journal of Dispersion Science and Technology》2017,38(7):943-952

Magnetic chitosan was prepared by co-precipitation with polymeric Schiff’s base resulting from the reaction of thiourea with glutaraldehyde. This material has great potential as high-effective sorbent for Remazol Brilliant Blue R (RBBR): maximum sorption capacity reached 0.441?mmol?g^?1 at pH 1.6 and at 25°C. Kinetic plots, pH dependence, isotherm data, and influences of ionic strength were reported. The data from equilibrium sorption experiments are well fitted to the Langmuir isotherm and the pseudo-second-order sorption kinetics indicates that chemisorption controls the process. The distribution coefficient was calculated at different temperatures and the thermodynamic parameters have been calculated: the sorption reaction is endothermic, spontaneous, and increases the entropy of the system. Alkaline solution (0.5?M NaOH) was used for desorbing RBBR from loaded sorbent. The sorbent exhibited good regenerability over several repeated adsorption/desorption cycles.  相似文献   

    

Nadras Othman  Siti Nadzirah Abdul Muttalib  Nur Izzati Ismail 《Macromolecular Symposia》2017,371(1):35-43

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Magda M. F. Ismail  Hanan G. Abdulwahab  Mohamed H. Elnagdi 《Journal of heterocyclic chemistry》2020,57(10):3584-3596

Novel hybrids, pyrazolinylpyrazoles, and pyrazolinyltriazoles were designed, synthesized, and screened for their anticancer activity. Eleven compounds were selected by the National Cancer Institute (NCI)/USA for anticancer screening at single high dose (10⁻⁵ M) in full NCI 60 cell panels. Two compounds: 4-aminopyrazole-5-carbonitrile, 5c (NSC-747630/1) and ethyl 4-aminopyrazole-5- carboxylate, 7d (NSC-747634/1) were the most active candidates of the series and were selected for further evaluation at five dose screening as they displayed significant growth inhibition with full panel median growth inhibition (GI₅₀) 5.47 and 2.24 μM, respectively. Both 5c and 7d hybrids exhibited broad spectrum antitumor activity; however 7d showed moderate selectivity (selectivity ratio 3.6) toward leukemia.  相似文献   

    

Mourad Ismail  Chun-Kong Law 《Studies in Applied Mathematics》2020,145(4):696-718

In this paper, we employ a difference equation approach to study the Plancherel-Rotach asymptotics of -orthogonal polynomials about their largest zeros. Our method for -difference equations is an analogue to the turning point problem for Hermite differential equations. It works well in the toy problems of Stieltjes-Wigert polynomials and -Hermite polynomials.  相似文献   

    

Kuakarun Krusong  Abbas Ismail  Karan Wangpaiboon  Piamsook Pongsawasdi 《Molecules (Basel, Switzerland)》2022,27(4)

Amylomaltase is a well-known glucan transferase that can produce large ring cyclodextrins (LR-CDs) or so-called cycloamyloses via cyclization reaction. Amylomaltases have been found in several microorganisms and their optimum temperatures are generally around 60–70 °C for thermostable amylomaltases and 30–45 °C for the enzymes from mesophilic bacteria and plants. The optimum pHs for mesophilic amylomaltases are around pH 6.0–7.0, while the thermostable amylomaltases are generally active at more acidic conditions. Size of LR-CDs depends on the source of amylomaltases and the reaction conditions including pH, temperature, incubation time, and substrate. For example, in the case of amylomaltase from Corynebacterium glutamicum, LR-CD productions at alkaline pH or at a long incubation time favored products with a low degree of polymerization. In this review, we explore the synthesis of LR-CDs by amylomaltases, structural information of amylomaltases, as well as current applications of LR-CDs and amylomaltases.  相似文献   

    

Eman A. Ahmed  Tahsin Shoala  Abdelsattar Abdelkhalik  Hoda A. S. El-Garhy  Ismail A. Ismail  Amro A. Farrag 《Molecules (Basel, Switzerland)》2022,27(5)

Phytoplasmas are economically important plant pathogenic bacterial diseases, causing severe yield losses worldwide. In this study, we tested nanoformulations such as glycyrrhizic acid ammonium salt (GAS), salicylic acid (SA), and boric acid (BA) as novel antimicrobial agents inducing the resistance against the phytoplasma disease in faba bean. The nanoparticles (NP) were foliar-applied to naturally phytoplasma-infected faba bean with three concentrations from each of SA, GAS, and BA, under field conditions. Nested PCR (using universal primer pairs P1/P7 and R16F2n/R16R2) were reacted positively with all symptomatic samples and gave a product size of approximately 1200 bp, while the healthy plant gave no results. Transmission electron microscopy examinations of phytoplasma-infected faba bean plants treated with different nanoparticles revealed that severe damage occurred in phytoplasma particle’s structure, degradation, malformation, lysis in the cell membrane, and the cytoplasmic leakage followed by complete lysis of phytoplasma cells. Exogenous application of GAS-NP (1.68 µM), SA-NP (0.28 µM), and BA-NP (0.124 µM) suppressed the infection percentage of phytoplasma by 75%, 50%, and 20%, and the disease severity by 84%, 64%, and 54%, respectively. Foliar application of nanoparticles improved Fv/Fm (maximum quantum efficiency of PSII Photochemistry), PI (the performance index), SPAD chlorophyll (the relative chlorophyll content), shoots height, and leaves number, thus inducing recovery of the plant biomass and green pods yield. The most effective treatment was GAS-NP at 1.68 µM that mediated substantial increases in the shoots’ fresh weight, shoots’ dry weight, number of pods per plant, and green pods yield by 230%, 244%, 202% and 178%, respectively, compared to those of infected plants not sprayed with nanoparticles. This study demonstrated the utility of using nanoparticles, particularly GAS-NP at 1.68 µM to suppress the phytoplasma infection.  相似文献   

    

Romaisa Arshad  Waleed A. Ismail  Batool Zara  Rabia Naseer  Sadia Minhas  Moeez Ansari  Fatema Akhter  Saria A. Khokhar  Abdullah Ali Alqahtani  Huda Abutayyem  Haytham Jamil Alswairki  Mohammad Khursheed Alam 《Molecules (Basel, Switzerland)》2022,27(7)

Chronic periodontitis and diabetes mellitus share a two-way relationship, the common factor being the inflammatory-mediated pathway, and various cytokines are released during this inflammatory cascade, one of which being matrix metalloproteinase-9. The aim of this study was to identify whether the levels of matrix metalloproteinase-9 are increased due to type-II diabetes mellitus in chronic periodontitis patients. It was an observational, analytical, case-control study. Thirty subjects were recruited in the test group, who were suffering from type-II diabetes mellitus and chronic periodontitis, and 30 subjects in the control group, who were subjects with chronic periodontitis but systemically healthy. Periodontal parameters, including the plaque score, gingival bleeding index, probing pocket depth and clinical attachment level of the subjects, were measured, saliva samples of all of the subjects were collected and salivary matrix metalloproteinase-9 levels were analyzed by an enzyme-linked immunosorbent assay (ELISA) technique. The statistical analysis was performed using SPSS 24. Overall, the matrix metalloproteinase-9 levels of the diabetic patients with chronic periodontitis were increased almost twofold (156.95 ± 29.80 ng/mL) compared to the levels in the controls (74.96 ± 6.32 ng/mL) (p < 0.001). Similarly, the periodontal parameters were far worse in diabetics with chronic periodontitis compared to the controls. The average gingivitis score for the test subjects was 78.45 ± 8.93%), compared to 29.32 ± 12.96% in the controls (p < 0.001). The mean probing pocket depth for the test group was 5.39 ± 0.60 mm, and, for the control group, it was 4.35 ± 0.31 mm (p < 0.001). For the test subjects, the average clinical attachment level was 5.86 ± 0.58 mm, and it was 4.66 ± 0.32 mm for the controls (p < 0.001). It was ascertained that there is a two-fold increase in the levels of salivary matrix metalloproteinase-9 in the test group compared to the control group. In addition, the level of periodontal apparatus destruction was greater in the test group. This proved that type-II diabetes mellitus influences the levels of matrix metalloproteinase-9 in humans and elevates them, causing further periodontal destruction.  相似文献