全文获取类型
收费全文 | 505篇 |
免费 | 18篇 |
专业分类
化学 | 380篇 |
晶体学 | 1篇 |
数学 | 25篇 |
物理学 | 117篇 |
出版年
2023年 | 4篇 |
2022年 | 16篇 |
2021年 | 16篇 |
2020年 | 20篇 |
2019年 | 12篇 |
2018年 | 20篇 |
2017年 | 13篇 |
2016年 | 21篇 |
2015年 | 11篇 |
2014年 | 16篇 |
2013年 | 25篇 |
2012年 | 35篇 |
2011年 | 38篇 |
2010年 | 19篇 |
2009年 | 21篇 |
2008年 | 25篇 |
2007年 | 22篇 |
2006年 | 24篇 |
2005年 | 17篇 |
2004年 | 10篇 |
2003年 | 6篇 |
2002年 | 6篇 |
2001年 | 4篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 5篇 |
1992年 | 8篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 9篇 |
1986年 | 2篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 10篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1972年 | 2篇 |
1970年 | 4篇 |
1969年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有523条查询结果,搜索用时 15 毫秒
71.
Leaf and root extracts of Clerodendrum infortunatum L. have been reported to show anthelmintic efficacy on a cestode parasite Raillietina tetragona. Its leaf showed no toxicity at 1000 mg/kg body weight but root toxicity study was not known. Therefore, our study is to test both leaf and root extracts at 2000 and 3000 mg/kg body weight concentration given orally for 15 days in four groups of Swiss albino mice, keeping another set as control (without plant extract). Weight and behaviour of mice were recorded daily. Feeding, movement pattern were normal in all treatments as that of control. Though body weight increase, there was no change in the relative organ weight. Biochemical and haematological studies revealed no significant change from control and no alteration in histopathological study of liver and kidney from that of control. The plant extracts thus shown to be safe for consumption. 相似文献
72.
Ali Faraat Nandi Utpal Trivedi Manisha Prakash Anuj Dahiya Meenakshi Sahu Puran Lal Kumar Robin Singh Gyanendra Nath 《Journal of Thermal Analysis and Calorimetry》2018,132(1):385-396
Journal of Thermal Analysis and Calorimetry - The aim of this work was to evaluate the quantitative characterization and pharmaceutical compatibility study of teneligliptin (TNG) with the commonly... 相似文献
73.
Nandi P Redko MY Petersen K Dye JL Lefenfeld M Vogt PF Jackson JE 《Organic letters》2008,10(23):5441-5444
A novel method for the desulfonation of secondary amines is described. Alkali metals absorbed into nanostructured silica (M-SG) were found to be useful solid-state reagents for the desulfonation of a range of N,N-disubstituted sulfonamides. M-SG reagents are room-temperature-stable free-flowing powders that retain the chemical reactivity of the parent metal, decreasing the danger and associated cost of using reactive metals. 相似文献
74.
Dey S Pal C Nandi D Giri VS Zaidlewicz M Krzeminski M Smentek L Hess BA Gawronski J Kwit M Babu NJ Nangia A Jaisankar P 《Organic letters》2008,10(7):1373-1376
3,3'-Bipyrroles 3 could be synthesized using a double Michael addition reaction involving diaroyl acetylene 1 and the appropriate 1,3-dicarbonyls 2 using ammonium acetate as a nitrogen source. The axial chirality of bipyrrole was anticipated from the X-ray crystal structure and DFT calculations and confirmed by separating the racemates on a chiral column and subsequent CD spectra of the enantiomers. The absolute configuration of the enantiomers was achieved by theoretical CD spectra calculation using the ZINDO method. 相似文献
75.
Nandi CK Parui PP Schmidt TL Heckel A Brutschy B 《Analytical and bioanalytical chemistry》2008,390(6):1595-1603
We have recently constructed a “DNA strut” consisting of two DNA-binding hairpin polyamides of Dervan-type connected via a
long flexible linker and were able to show that this strut can be used to sequence-selectively connect DNA helices. This approach
provides a second structural element (besides the Watson–Crick base pairing) for the assembly of higher-order DNA nanoarchitectures
from smaller DNA building blocks. Since none of the existing analytical techniques for studying this kind of system were found
suitable for detection and quantification of the formation of the resulting complexes, we chose fluorescence correlation spectroscopy
(FCS). In the present study we show that FCS allowed us in a versatile and fast way to investigate the binding of Dervan polyamides
to DNA. In particular it also shows its power in the quantitative detection of the formation of multimeric complexes and the
in investigation of binding under nonphysiological conditions.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
76.
For sensitive analysis of cancer biomarker carcinoembryonic antigen (CEA), an amperometric sandwich-type aptasensor is proposed based on a signal amplification strategy of Au@Pt bimetallic nanoprobes. As the excellent catalytic activity to hydrogen peroxide (H2O2), core-shell Au@Pt nanoparticles are employed as nanoprobes by conjugating directly with the secondary aptamer of CEA (Apt-II). Due to the synergic recognition effect of dual aptamers and the excellent catalytic activity of nanoprobes, this amperometric sandwich-type aptasensor for CEA exhibits high specificity and good sensitivity with a limit of detection of 0.31 ng/mL, along with a wide linear range from 0.1 ng/mL to 100 ng/mL. 相似文献
77.
Christina Wartmann Dr. Shiny Nandi Dr. Jörg-Martin Neudörfl Prof. Dr. Albrecht Berkessel 《Angewandte Chemie (International ed. in English)》2023,62(35):e202306584
The titanium complex of the cis-1,2-diaminocyclohexane (cis-DACH) derived Berkessel-salalen ligand is a highly efficient and enantioselective catalyst for the asymmetric epoxidation of terminal olefins with hydrogen peroxide (“Berkessel-Katsuki catalyst”). We herein report that this epoxidation catalyst also effects the highly enantioselective hydroxylation of benzylic C−H bonds with hydrogen peroxide. Mechanism-based ligand optimization identified a novel nitro-salalen Ti-catalyst of the highest efficiency ever reported for asymmetric catalytic benzylic hydroxylation, with enantioselectivities of up to 98 % ee, while overoxidation to ketone is marginal. The novel nitro-salalen Ti-catalyst also shows enhanced epoxidation efficiency, as evidenced by e.g. the conversion of 1-decene to its epoxide in 90 % yield with 94 % ee, at a catalyst loading of 0.1 mol-% only. 相似文献
78.
In this paper, for the first time, we report a detailed study of the temperature-dependent solvation dynamics of a probe fluorophore, coumarin-500, in AOT/isooctane reverse micelles (RMs) with varying degrees of hydration (w0) of 5, 10, and 20 at four different temperatures, 293, 313, 328, and 343 K. The average solvation time constant becomes faster with the increase in w0 values at a particular temperature. The solvation dynamics of a RM with a fixed w0 value also becomes faster with the increase in temperature. The observed temperature-induced faster solvation dynamics is associated with a transition of bound- to free-type water molecules, and the corresponding activation energy value for the w0 = 5 system has been found to be 3.4 kcal mol-1, whereas for the latter two systems, it is approximately 5 kcal mol-1. Dynamic light scattering measurements indicate an insignificant change in size with temperature for RMs with w0 = 5 and 10, whereas for a w0 = 20 system, the hydrodynamic diameter increases with temperature. Time-resolved fluorescence anisotropy studies reveal a decrease in the rotational restriction on the probe with increasing temperature for all systems. Wobbling-in-cone analysis of the anisotropy data also supports this finding. 相似文献
79.
Nandi N Thirumoorthy K Vollhardt D 《Langmuir : the ACS journal of surfaces and colloids》2008,24(17):9489-9494
Chiral discrimination in Langmuir monolayers of amphiphilic 1-stearylamine-glycerol is studied using the hybrid quantum mechanical/molecular mechanical method. Using the experimental information about the lattice structure [D. Vollhardt, U. Gehlert, J. Phys. Chem. B. 2002, 106, 4419], the intermolecular interaction profiles for enantiomeric and racemic pair are studied as a function of mutual tilt and azimuth for different values of intermolecular separation. The present study reveals that, at shorter separation, the interaction profile of the racemic pair has deeper minima than the enantiomeric pair, whereas at larger separation the minimum of the enantiomeric pair is deeper. Thus, the theoretical studies reveal an interesting crossover from heterochiral preference to homochiral preference in 1-stearylamine-glycerol monolayers, with the increase in the intermolecular separation corresponding to a larger area per molecule in the monolayer. This predicts that, with gradual compression, the interactions between racemic pair dominate the experimental features, whereas, under nonequilibrium conditions at the beginning of the formation of the condensed phase, the experimental characteristics of homochirality are observable. The study conclusively shows that the chiral structure of the molecule and the lattice packing drive the chiral preference at the mesoscopic level. 相似文献
80.
Thirumoorthy K Nandi N Vollhardt D 《Langmuir : the ACS journal of surfaces and colloids》2007,23(13):6991-6996
The role of dipolar interactions in determining the lipid domain shapes at the air-water interface with a change in the chemical structure of the head groups of lipids is theoretically studied. The phospholipids considered are dipalmitoylphosphatidylcholine (D,L-DPPC) and dipalmitoylphosphatidylethanolamine (DPPE). Despite closely similar chemical structures, the domains of the two lipids are strikingly different. The DPPC domains exhibit elongated arms, while the DPPE domains are nearly round-shaped. To compare the dipolar repulsions in the domains of the two phospholipids, different energy-minimized conformers of DPPC and DPPE are studied using the semiempirical quantum chemical method (PM3). It is found that the dipole moment of DPPC is significantly larger than that of DPPE. The in-plane and out-of-plane components of the dipole moments are calculated using grazing incidence X-ray diffraction data at different surface pressure values, as used in the experiment. The result indicates that the magnitude of the dipolar interaction is significantly larger in DPPC than that in DPPE over the surface pressure range considered. The enhanced dipolar repulsion corroborates well with the difference in the domain shapes in the two phospholipid monolayers. The larger dipolar repulsion in DPPC leads to development of elongated domain arms, while relatively less dipolar repulsion allows a closed shape of the condensed-phase DPPE domains. 相似文献