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101.
Fahadul Islam Saikat Mitra Talha Bin Emran Zidan Khan Nikhil Nath Rajib Das Rohit Sharma Ahmed Abdullah Al Awadh Moon Nyeo Park Bonglee Kim 《Molecules (Basel, Switzerland)》2022,27(17)
Gastric cancer is one of the most common cancers of the gastrointestinal tract. Although surgery is the primary treatment, serious maladies that dissipate to other parts of the body may require chemotherapy. As there is no effective procedure to treat stomach cancer, natural small molecules are a current focus of research interest for the development of better therapeutics. Chemotherapy is usually used as a last resort for people with advanced stomach cancer. Anti-colon cancer chemotherapy has become increasingly effective due to drug resistance and sensitivity across a wide spectrum of drugs. Naturally-occurring substances have been widely acknowledged as an important project for discovering innovative medications, and many therapeutic pharmaceuticals are made from natural small molecules. Although the beneficial effects of natural products are as yet unknown, emerging data suggest that several natural small molecules could suppress the progression of stomach cancer. Therefore, the underlying mechanism of natural small molecules for pathways that are directly involved in the pathogenesis of cancerous diseases is reviewed in this article. Chemotherapy and molecularly-targeted drugs can provide hope to colon cancer patients. New discoveries could help in the fight against cancer, and future stomach cancer therapies will probably include molecularly formulated drugs. 相似文献
102.
Mintu Munda Rhituparna Nandi Vipin R. Gavit Sourav Kundu Sovan Niyogi Alakesh Bisai 《Chemical science》2022,13(39):11666
Concise total syntheses of naturally occurring antiviral indolosesquiterpene alkaloids, xiamycin C (2a), D (2b), E (2c) and F (2d), have been achieved via a late-stage oxidative δ-Csp3–H functionalization of an advanced pentacyclic enone intermediate 8. This strategy takes advantage of ipso-nitration of naturally occurring abietane diterpenoids to synthesize o-bromo nitroarene derivative 11. A Suzuki–Miyaura coupling of 11 with phenylboronic acid followed by Cadogan''s ring closure provided a modular approach to a carbazole ring required for a functionalized pentacyclic core of indolosesquiterpene alkaloids.Enantioenriched enone 8 was synthesized via three key transformations: ipso-nitration of abietane diterpenoids to furnish o-bromo nitroarene 11, Suzuki coupling with phenylboronic acid, and Cadogan''s reductive ring closure to craft a carbazole ring. 相似文献
103.
The melting of isothermally crystallized poly(vinylidene fluoride) (PVF2), produced in the intercrystalline spaces of poly(ethylene terephthalate) (PET) from its blends, showed a unique behavior: the melting temperature decreased with the increasing crystallinity of PVF2 (i.e., with increasing crystallization time) for PVF2 volume fractions of 0.64 and 0.51. The melting temperature of already crystallized PET also decreased as the PVF2 crystallization progressed and the isothermal crystallization temperature of PVF2 increased. Separate reasons were proposed to account for these behaviors. The equilibrium melting temperatures of PVF2 in the blends, measured by the Hoffman–Weeks extrapolation procedure, were used to calculate the polymer–polymer interaction parameter (χ21); only the noncrystallized portion of PET contributing to the mixed amorphous phase was considered. The χ21value (−1.75) was lower than χ12 (−0.14), calculated from the melting temperature depression of PET. However, when they were normalized to the unit volumes of the respective components, the two values were found to be the same. The crystallization rate of PVF2 decreased with an increasing volume fraction of PET in the blend. The Avrami exponent increased for the volume fraction of PVF2 (0.77) and then progressively decreased with an increasing volume fraction of PET. A gradual change in the nature of the regime transition from regime II/regime I to regime III/regime II with increasing PET concentration was observed. The value of the chain-extension factor of PVF2 significantly increased with an increase in the PET concentration in the blends. © 2004 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 42: 2215–2227, 2004 相似文献
104.
105.
Morrison R Schmidt D Procario M Johnson DR Lingel K Rankin P Smith JG Alexander J Artuso M Bebek C Berkelman K Besson D Browder TE Cassel DG Cheu E Coffman DM Drell PS Ehrlich R Galik RS Garcia-Sciveres M Geiser B Gittelman B Gray SW Hartill DL Heltsley BK Honscheid K Kandaswamy J Katayama N Kreinick DL Lewis JD Ludwig GS Masui J Mevissen J Mistry NB Nandi S Ng CR Nordberg E O'Grady C Patterson JR Peterson D Pisharody M Riley D Sapper M Selen M Worden H Worris M Avery P Freyberger A Rodriguez J 《Physical review letters》1991,67(13):1696-1700
106.
Akerib DS Barish B Cowen DF Eigen G Stroynowski R Urheim J Weinstein AJ Morrison R Schmidt D Procario M Johnson DR Lingel K Rankin P Smith JG Alexander J Bebek C Berkelman K Besson D Browder TE Cassel DG Cheu E Coffman DM Drell PS Ehrlich R Galik RS Garcia-Sciveres M Geiser B Gittelman B Gray SW Hartill DL Heltsley BK Honscheid K Kandaswamy J Katayama N Kreinick DL Lewis JD Ludwig GS Masui J Mevissen J Mistry NB Nandi S Ng CR Nordberg E O'Grady C Patterson JR Peterson D Pisharody M Riley D 《Physical review letters》1991,67(13):1692-1695
107.
Daoudi M Ford WT Johnson DR Lingel K Lohner M Rankin P Smith JG Alexander J Bebek C Berkelman K Besson D Browder TE Cassel DG Cheu E Coffman DM Drell PS Ehrlich R Galik RS Garcia-Sciveres M Geiser B Gittelman B Gray SW Hartill DL Heltsley BK Honscheid K Kandaswamy J Katayama N Kim PC Kreinick DL Lewis JD Ludwig GS Masui J Mevissen J Mistry NB Nandi S Ng CR Nordberg E O'Grady C Patterson JR Peterson D Pisharody M Riley D Sapper M Selen M Worden H Worris M Avery P Freyberger A Rodriguez J 《Physical review D: Particles and fields》1992,45(11):3965-3975
108.
109.
Alexander J Artuso M Bebek C Berkelman K Browder T Cassel DG Cheu E Coffman DM Crawford G DeWire JW Drell PS Ehrlich R Galik RS Gittelman B Gray SW Halling AM Hartill DL Heltsley BK Kandaswamy J Katayama N Kreinick DL Lewis JD Ludwig GS Mistry NB Mueller J Nandi S Nordberg E O'Grady C Peterson D Pisharody M Riley D Sapper M Selen M Silverman A Stone S Worden H Worris M Sadoff AJ Avery P Besson D Garren L Yelton J Bowcock T Kinoshita K Pipkin FM Procario M Wilson R Wolinski J Xiao D Zhu Y 《Physical review letters》1990,65(13):1531-1534
110.