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51.
Structural Chemistry - A theoretical investigation of the model diazotization/dediazotization of N-aminopiperidine and N-aminomorpholine at the DFT (B3LYP/6-31+G(d)) level indicated that the... 相似文献
52.
A protein''s adaptive response to its substrates is one of the key questions driving molecular physics and physical chemistry. This work employs the recently developed structure-mechanics statistical learning method to establish a mechanical perspective. Specifically, by mapping all-atom molecular dynamics simulations onto the spring parameters of a backbone-side-chain elastic network model, the chemical moiety specific force constants (or mechanical rigidity) are used to assemble the rigidity graph, which is the matrix of inter-residue coupling strength. Using the S1A protease and the PDZ3 signaling domain as examples, chains of spatially contiguous residues are found to exhibit prominent changes in their mechanical rigidity upon substrate binding or dissociation. Such a mechanical-relay picture thus provides a mechanistic underpinning for conformational changes, long-range communication, and inter-domain allostery in both proteins, where the responsive mechanical hotspots are mostly residues having important biological functions or significant mutation sensitivity.Protein residues exhibit specific routes of mechanical relay as the adaptive responses to substrate binding or dissociation. On such physically contiguous connections, residues experience prominent changes in their coupling strengths. 相似文献
53.
Raj K. Bansal Ruchi Mahnot Dinesh C. Sharma Konstantin Karaghiosoff Alfred Schmidpeter 《Heteroatom Chemistry》1992,3(4):351-357
The title compounds 3 and 7 are novel heterocyclic systems incorporating two-coordinate phosphorus. They are obtained in reasonable to good yields from the condensation of suitable 2-ethyl-3-alkylthiazolinium and -benzothiazolium bromides 2 and 6 with phosphorus trichloride in the presence of triethylamine in an aprotic solvent. Intermediate dichlorophosphino-substituted N-ylides can be observed or isolated in some cases. From a 2-methyl-3-alkylthiazolinium bromide ( 2a ), a 1-(dichlorophosphino) substituted 1, 3-azaphospholo[5,1-b]thiazoline ( 4 ) was obtained. The chemical shift of the two-coordinate phosphorus in 1,3-azaphosphole derivatives clearly reflects the influence of the heterocyclic system annulated to its 1,5-bond and of the substituents in its 2-and 4-positions. 相似文献
54.
Gopal Lamichhane Prakash Raj Pandeya Ramakanta Lamichhane Su-jin Rhee Hari Prasad Devkota Hyun-Ju Jung 《Molecules (Basel, Switzerland)》2022,27(3)
Background: Ponciri Fructus, a crude drug consisting of the dried immature fruits of Poncirus trifoliata (L.) Raf., is a popular folk medicine used for the treatment of allergy and gastrointestinal disorders in Korea and China. In this study, the anti-adipogenic activity of extracts and isolated compounds were evaluated using 3T3-L1 preadipocytes. Methods: Dried immature fruits were extracted and fractionated into n-hexane, ethyl acetate (EtOAc), n-butanol and water-soluble fractions. The ethanol extract and fractions were tested for anti-adipogenic activity in the 3T3-L1 cell line. The active fractions (n-hexane and EtOAc fractions) were further subjected to chromatographic techniques to isolate and identify active compounds. Furthermore, the isolated compounds were evaluated for their anti-adipogenic activity. Results: Altogether, seven compounds, including two flavonoids, one phytosteroid and four coumarin derivatives, were isolated. Ethanol extract, n-hexane fraction, EtOAc fraction and three isolated compounds (phellopterin, oxypeucedanin and poncirin) showed significant anti-adipogenic activity as observed by reduced lipid deposition in differentiated 3T3-L1 cells. Further, oxypeucedanin downregulated the key adipogenic markers, such as peroxisome proliferator-activated receptors proteins γ (PPAR-γ), sterol response element binding proteins-1 (SREBP-1), CCAAT/enhancer binding proteins-α (C/EBP-α), adipocyte-specific lipid binding proteins (FABP-4), adipocyte fatty acid binding proteins (aP2), lipoprotein lipase (LPL) and leptin. Conclusion: This study indicated that the ethanol extract, hexane fraction and ethyl acetate fraction of P. trifoliata fruits possess strong anti-adipogenic activity, containing the active compounds such as phellopterin, oxypeucedanin and poncirin. Further research is recommended to explore their efficacy and safety in animal and clinical models. 相似文献
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This paper presents an analysis of diffraction effects taking place at different Schlieren diffracting elements. Two types
of diffraction effects are prominent in the Schlieren schemes. One is diffraction of direct light (source image) at the Schlieren
element, which limits the sensitivity and resolution of Schlieren systems. The second type is the diffraction of light deflected
from the test object at the Schlieren-diffracting element. This second type of diffraction degrades the quality of Schlieren
results. Experimental results showing the effect of diffraction of light deflected from the test object at a phase knife-edge,
corner of a square phase aperture and an optical fiber tip as Schlieren diffracting elements have been presented and discussed.
相似文献
58.
We study spectral distortions of diffuse ultra-high energy (UHE) neutrino flavour fluxes resulting due to physics beyond the Standard Model (SM). Even large spectral differences between flavours at the source are massaged into a common shape at earth by SM oscillations, thus, any significant observed spectral differences are an indicator of new physics present in the oscillation probability during propagation. Lorentz symmetry violation (LV) and neutrino decay are examples, and result in significant distortion of the fluxes and of the well-known bounds on them, which may allow UHE detectors to probe LV parameters, lifetimes and the mass hierarchy over a broad range. 相似文献
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