Einige Sätze über Reihen von allgemeinen Orthogonalfunktionen

Ohne Zusammenfassung     

Zur additiven Primzahltheorie algebraischer Zahlkörper. III.

Ohne Zusammenfassung     

Untersuchungen zur Silicationenkonstitution in N-(2)Hydroxyethyl- und N-(2)Hydroxypropylpyridiniumsilicatlösungen. Bildung von N-(2)Hydroxypropylpyridiniumsilicathydrat

Investigations on the Silicate Ion Constitution in N-(2)hydroxyethyl- and N-(2)hydroxypropylpyridinium Silicate Solutions Crystallization of N-(2)hydroxypropylpyridinium Silicate Hydrate In N-(2)hydroxyethyl- and N-(2)hydroxypropylpyridinium silicate solutions are present mainly double three-ring and double four-ring silicate ions. With increasing concentration their molar ratio shifts in direction to double four-ring silicate. Simultaneously the amount of the low-condensed silicates decreases. An increasing concentration of the alkali hydroxide destroys the double ring cages. From solutions of N-(2)hydroxypropylpyridinium silicate with molar ratios of the pyridinium base to silicon dioxide of 0.5 to 2 and from solutions with a certain amount of alkali hydroxide an acid- N-(2)hydroxypropylpyridinium-double-four-ring silicate hydrate is obtained by crystallization.     

On the Electronic Structure of Phosphorus- (III)-p-π-Bonded Systems: UV- and PE- Spectroscopic Investigations of Phosphaalkenes

Abstract

UV- and He-I-p.e. spectra of phosphaalkenes 1 are discussed.     

Twistor spinors and gravitational instantons

We construct a complete Riemannian metric on the four-dimensional vector space ⁴ which carries a two-dimensional space of twistor spinor with common zero point. This metric is half-conformally flat but not conformally flat. The construction uses a conformal completion at infinity of theEguchi-Hanson metric on the exterior of a closed ball in ⁴.     

Characterization of depleted uranium oxides fabricated using different processing methods

Identifying both physical and chemical characteristics of Special Nuclear Material (SNM) production processes is the corner stone of nuclear forensics. Typically, processing markers are based on measuring an interdicted sample’s bulk chemical properties, such as the elemental or isotopic composition, or focusing on the chemical and physical morphology of only a few particles. Therefore, it is imperative that known SNM processes be fully characterized from bulk to trace level for each particle size range. This report outlines a series of particle size measurements and fractionation techniques that can be applied to a bulk SNM powders, categorizing both chemical and physical properties in discrete particle size fractions. This will be demonstrated by characterizing the process signatures of a series of different depleted uranium oxides prepared at increasing firing temperatures (350–1100 °C). Results will demonstrate how each oxides’ material density, particle size distribution, and morphology varies.     

Applying microdroplets as sensors for label-free detection of chemical reactions

Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level.     

Druggable Allosteric Sites in β-Propeller Lectins

Carbohydrate-binding proteins (lectins) are auspicious targets in drug discovery to combat antimicrobial resistance; however, their non-carbohydrate drug-like inhibitors are still unavailable. Here, we present a druggable pocket in a β-propeller lectin BambL from Burkholderia ambifaria as a potential target for allosteric inhibitors. This site was identified employing ¹⁹F NMR fragment screening and a computational pocket prediction algorithm SiteMap. The structure–activity relationship study revealed the most promising fragment with a dissociation constant of 0.3±0.1 mM and a ligand efficiency of 0.3 kcal mol^?1 HA^?1 that affected the orthosteric site. This effect was substantiated by site-directed mutagenesis in the orthosteric and secondary pockets. Future drug-discovery campaigns that aim to develop small molecule inhibitors can benefit from allosteric sites in lectins as a new therapeutic approach against antibiotic-resistant pathogens.