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排序方式: 共有251条查询结果,搜索用时 15 毫秒
121.
Rabe KS Gandubert VJ Spengler M Erkelenz M Niemeyer CM 《Analytical and bioanalytical chemistry》2008,392(6):1059-1073
Cytochrome P450s constitute a highly fascinating superfamily of enzymes which catalyze a broad range of reactions. They are
essential for drug metabolism and promise industrial applications in biotechnology and biosensing. The constant search for
cytochrome P450 enzymes with enhanced catalytic performances has generated a large body of research. This review will concentrate
on two key aspects related to the identification and improvement of cytochrome P450 biocatalysts, namely the engineering and
assaying of these enzymes. To this end, recent advances in cytochrome P450 development are reported and commonly used screening
methods are surveyed. 相似文献
122.
Salzmann I Duhm S Heimel G Rabe JP Koch N Oehzelt M Sakamoto Y Suzuki T 《Langmuir : the ACS journal of surfaces and colloids》2008,24(14):7294-7298
Synchrotron x-ray diffraction reciprocal space mapping was performed on perfluoropentacene (PFP) thin films on SiO2 in order to determine the crystal structure of a novel, substrate-induced thin film phase to be monoclinic with unit cell parameters of a = 15.76 +/- 0.02 A, b = 4.51 +/- 0.02 A, c = 11.48 +/- 0.02 A, and beta = 90.4 +/- 0.1 degrees . Moreover, layered and co-deposited heterostructures of PFP and pentacene (P) were investigated by specular and grazing-incidence x-ray diffraction, atomic force microscopy, and Fourier-transform infrared spectroscopy. For a ca. three-monolayers-thick PFP film grown on a P underlayer, slightly increased lattice spacing was found. In contrast, co-deposited P/PFP films form a new mixed-crystal structure with no detectable degree of phase separation. These results highlight the structural complexity of these technically relevant molecular heterojunctions for use in organic electronics. 相似文献
123.
Wu P Volkmer D Bredenkötter B Kurth DG Rabe JP 《Langmuir : the ACS journal of surfaces and colloids》2008,24(6):2767-2771
We report on the self-assembly of several surfactant-encapsulated clusters (SECs) on the basal plane of graphite consisting of the doughnut-shaped tungstophosphate anion [Na(H2O)P5W30O110] covered by a hydrophobic shell of surfactants. Well-ordered rodlike structures are observed using scanning force microscopy. No such ordering is observed if the surfactant methyltrioctadecylammonium is used for encapsulation, suggesting that the density of alkyl chains around the polyoxometalate cluster is an important factor in determining the order of SEC assemblies on graphite. Coadsorption of tetratetracontane (n-C44H90) and (DODA)14[Na(H2O)P5W30O110] results in single, isolated SECs on a buffer layer of tetratetracontane, as determined by scanning tunneling microscopy. 相似文献
124.
Salzmann I Duhm S Heimel G Oehzelt M Kniprath R Johnson RL Rabe JP Koch N 《Journal of the American Chemical Society》2008,130(39):12870-12871
For the prototypical conjugated organic molecules pentacene and perfluoropentacene, we demonstrate that the surface termination of ordered organic thin films with intramolecular polar bonds (e.g., -H versus -F) can be used to tune the ionization energy. The collective electrostatics of these oriented bonds also explains the pronounced orientation dependence of the ionization energy. Furthermore, mixing of differently terminated molecules on a molecular length scale allows continuously tuning the ionization energy of thin organic films between the limiting values of the two pure materials. Our study shows that surface engineering of organic semiconductors via adjusting the polarity of intramolecular bonds represents a generally viable alternative to the surface modification of substrates to control the energetics at organic/(in)organic interfaces. 相似文献
125.
V. Eckardt H.J. Gebauer P. Joos H. Meyer B. Naroska D. Notz W.J. Podolsky G. Wolf S. Yellin G. Drews H. Nagel E. Rabe 《Physics letters. [Part B]》1973,43(3):240-244
Production and decay characteristics of electroproduced rho mesons were studied in the final state epπ+π?. 相似文献
126.
127.
J. D'Ans G. Dorfmüller J. Großfeld H. Leonhardt Ph. Naoúm A. Berthman G. Jayme R. Korn F. Burgstaller H. Sommer H. Mendrzyk W. Weltzien Karin Windeck-Schulze E. Ristenpart E. Sauer A. Küntzel S. Reissinger W. Esch W. Toeldte H. P. Kaufmann S. Funke W. Halden B. Wurzschmitt H. Thomas E. van Hulle E. Messmer P. Rabe H. van Haasy G. Hamann T. Berglund M. Sartori Gebührenaussehuß für chemische Arbeiten 《Analytical and bioanalytical chemistry》1940,119(11-12):422-425
128.
Hydrolysis of a Lipid Membrane by Single Enzyme Molecules: Accurate Determination of Kinetic Parameters 下载免费PDF全文
Dr. Michael Rabe Dr. Seyed R. Tabaei Dr. Henrik Zetterberg Dr. Vladimir P. Zhdanov Dr. Fredrik Höök 《Angewandte Chemie (International ed. in English)》2015,54(3):1022-1026
The accurate determination of the maximum turnover number and Michaelis constant for membrane enzymes remains challenging. Here, this problem has been solved by observing in parallel the hydrolysis of thousands of individual fluorescently labeled immobilized liposomes each processed by a single phospholipase A2 molecule. The release of the reaction product was tracked using total internal reflection fluorescence microscopy. A statistical analysis of the hydrolysis kinetics was shown to provide the Michaelis–Menten parameters with an accuracy better than 20 % without variation of the initial substrate concentration. The combined single‐liposome and single‐enzyme mode of operation made it also possible to unravel a significant nanoscale dependence of these parameters on membrane curvature. 相似文献
129.