The diffusion-control limit revisited

We consider nonequilibrium adsorption to a freshly formed surface. Owing to the initial lack of equilibrium, the common diffusion-control assumption is inconsistent at small times. A uniform small-time asymptotic approximation is constructed for a Langmuir-type system in terms of the small parameter epsilon representing the ratio of the respective kinetic and diffusive time scales of the problem. The diffusion-control approximation becomes valid only when t>epsilon. The adsorption results are applied to the calculation of the dynamic surface tension.     

Deuteron formation in nuclear collisions

Deuteron production cross sections are calculated from an intranuclear cascade model for Ne + U and Ar + Ca at 400 MeV/A. In effect, there are no adjustable parameters in this calculation. The parameters of the cascade code are fixed by sum charged inclusive data. Furthermore, the high momentum deuteron inclusive distribution is found to be insensitive to the details of the deuteron wave function. This latter observation leads to a justification of a generalized coalescence formula involving both momentum and spatial coordinates. Satisfactory agreement is found between our calculations and both the untriggered and high multiplicity triggered inclusive spectra of deuterons with energies ?50 MeV/A.     

Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus

Several small molecule vinyl sulfones were found to exhibit irreversible time-dependent inhibition of the Staphylococcus aureus sortase SrtA in vitro. A representative of these compounds was shown to impair the ability of S. aureus bacteria to bind fibronectin-coated surfaces through in vivo inhibition of SrtA-mediated linkage of fibronectin to the cell surface. These data highlight the potential use of small molecule vinyl sulfones as chemotherapeutics to prevent adhesion to and colonization of host tissues during S. aureus infection.     

Temperature dependence of near-resonant vibration ↔ rotation energy transfer

V ? R,T deactivation of the ν₄ (243 cm^?1) level in BCl₃ by HCl has been measured over the range 220–340 K, with an infrared double resonance technique. The deactivation probabilities show an inverse temperature dependence below room temperature, indicating that long-range attractive forces are important in the resonant transfer process. The results are compared with the theory of Sharma and Brau.     

A new multidimensional integral relationship between heat flux and temperature for direct internal assessment of heat flux

This paper derives a new integral relationship between heat flux and temperature in a transient, two-dimensional heat conducting half space. A unified mathematical treatment is proposed that is extendable to higher-dimensional and finite-region geometries. The analytic expression provides the local heat flux perpendicular to the front surface solely based on an embedded line of temperature sensors parallel to the surface. The relationship does not require apriori knowledge of the surface boundary condition. A new sensor strategy is analytically conceived based on the integral relationship for estimating the local, in-depth heat flux without surface instrumentation. It should further be clarified that the integral relationship requires only knowledge of the local, in-depth temperature and heating/cooling rate (time rate of change of temperature). The resulting formulation is mildly ill-posed and either requires digital filtering of the temperature signal to remove high frequency components of noise or the development of direct heating/cooling rate sensors. This paper (a) develops the new mathematical relationship; (b) demonstrates that the proposed relationship reduces to well-known (i) one-dimensional results under the appropriate assumptions; and, (ii) two-dimensional surface results; and, (c) provides a simple numerical example validating the concept.     

Prior exposure to an attenuated <Emphasis Type="Italic">Listeria</Emphasis> vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a <Emphasis Type="Italic">Listeria</Emphasis>vaccine in the induction of immune responses against HIV

Background  

We have evaluated an attenuated Listeria monocytogenes (Lm) candidate vaccine vector in nonhuman primates using a delivery regimen relying solely on oral vaccination. We sought to determine the impact of prior Lm vector exposure on the development of new immune responses against HIV antigens.     

Constraining inverse stefan design problems

A new formulation possessing stable numerical characteristics is presented for inverse Stefan design processes. In such processes, the goal of the analysis is to design transient boundary conditions which produce the desired interfacial surface motion. This subclass of mildly ill-posed mathematical problems is amenable to the proposed solution methodology. This investigation presents a fixed-front differential formulation from which a weighted residual statement is developed. Orthogonal collocation is used to obtain numerical results illustrating the merit of imposing physical constraints in the mathematical model. These mathematical constraints can be viewed as design specifications and are available to the designer or experimentalist. The proposed methodology is flexible and can be generalized to problems involving continuous casting or crystal growth. Finally, symbolic manipulation is used for augmenting the computational methodology.     

Cation distribution in natural ferrites

Mössbauer spectra of jacobsite have been recorded at temperatures of 4.2, 125, 180, 240 and 300 K and with an external magnetic field of 60 kOe applied parallel to the incident radiation at 4.2 K. The results show the presence of two different magnetic hyperfine interactions associated with the iron nuclei. Spectra of samples in external magnetic fields indicate the same sign for the magnetic hyperfine interactions, implying that both iron ions occupy only the octahedral sublattice. These results are compared with data from synthetic stoichiometry manganese ferrite, and a model of cation distribution, assuming the existence of vacancies, is proposed. According to this model, the mineral jacobsite is rich in manganese compared with stoichiometric MnFe₂O₄ ferrite.