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51.
A. A. Cowley P. G. Roos H. G. Pugh V. K. C. Cheng R. Woody III 《Nuclear Physics A》1974,220(3):429-437
The 3He(p, 2p)d and 3He(p, pd)p reactions have been compared at three bombarding energies from 65 to 100 MeV. A comparison of plane wave impulse approximation calculations to the experimental data indicates that multiple scattering effects are large and energy dependent but that they primarily produce a uniform reduction in cross section. Although multiple scattering effects are large the ratio of the cross sections for the two reactions is in agreement with that predicted by the impulse approximation. 相似文献
52.
Dr. Yu Cao Dr. David T. Rodgers Dr. Juanjuan Du Insha Ahmad Eric N. Hampton Dr. Jennifer S. Y. Ma Dr. Magdalena Mazagova Dr. Sei‐hyun Choi Dr. Hwa Young Yun Dr. Han Xiao Dr. Pengyu Yang Xiaozhou Luo Dr. Reyna K. V. Lim Holly M. Pugh Dr. Feng Wang Dr. Stephanie A. Kazane Dr. Timothy M. Wright Dr. Chan Hyuk Kim Prof. Peter G. Schultz Dr. Travis S. Young 《Angewandte Chemie (International ed. in English)》2016,55(26):7520-7524
Chimeric antigen receptor T (CAR‐T) cells have demonstrated promising results against hematological malignancies, but have encountered significant challenges in translation to solid tumors. To overcome these hurdles, we have developed a switchable CAR‐T cell platform in which the activity of the engineered cell is controlled by dosage of an antibody‐based switch. Herein, we apply this approach to Her2‐expressing breast cancers by engineering switch molecules through site‐specific incorporation of FITC or grafting of a peptide neo‐epitope (PNE) into the anti‐Her2 antibody trastuzumab (clone 4D5). We demonstrate that both switch formats can be readily optimized to redirect CAR‐T cells (specific for the corresponding FITC or PNE) to Her2‐expressing tumor cells, and afford dose‐titratable activation of CAR‐T cells ex vivo and complete clearance of the tumor in rodent xenograft models. This strategy may facilitate the application of immunotherapy to solid tumors by affording comparable efficacy with improved safety owing to switch‐based control of the CAR‐T response. 相似文献
53.
54.
A key feature of a general nonlinear partially hyperbolic dynamical system is the absence of differentiability of its invariant splitting. In this paper, we show that often partial derivatives of the splitting exist and the splitting depends smoothly on the dynamical system itself. 相似文献
55.
56.
Several bands of nitrous oxide occurring in the region of about 5.3 μm have been measured by using a high resolution vacuum infrared spectrograph. The molecular constants derived from the data have been given along with the basic data. 相似文献
57.
Drent E van Dijk R van Ginkel R van Oort B Pugh RI 《Chemical communications (Cambridge, England)》2002,(9):964-965
Non-alternating ethene-CO copolymerisation is catalysed by a new series of [P-O]Pd catalysts based on o-alkoxy derivatives of diphenylphosphinobenzene sulfonic acid. 相似文献
58.
In this paper we dramatically expand the domain of known stably ergodic, partially hyperbolic dynamical systems. For example,
all partially hyperbolic affine diffeomorphisms of compact homogeneous spaces which have the accessibility property are stably
ergodic. Our main tools are the new concepts – julienne density point and julienne quasi-conformality of the stable and unstable
holonomy maps. Julienne quasi-conformal holonomy maps preserve all julienne density points.
Received June 14, 1999 / final version received October 25, 1999 相似文献
59.
60.
Charles C. Pugh 《Journal of Dynamics and Differential Equations》1992,4(4):545-553
Given a smooth flow and two orbits such that theω-limit set of the first meets theα-limit set of the second, can the flow be C1-perturbed to make the orbits coincide? The answer is shown to be “not always.” 相似文献