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4-Aryl-6-methyl-pyrimidine-2(1H)-one scaffolds of Biginelli type were subjected to C–O cross-coupling reactions using symmetrical diaryliodonium salts under transition metal-free conditions to afford 2-aryloxy pyrimidine derivatives in good to excellent yields. 相似文献
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The kinetics of the environmentally important oxidation of sulfur(IV) by oxygen in acetate buffered medium in the presence
of Fe(III) and the pH range 5.27–5.70 has been studied. The results were in agreement with the rate law:
The role of iron(III) appears to be that of production of SO3− radicals in Fe(III)SO32− complex by an internal 1-equivalent redox reaction. Subsequently, a radical mechanism involving oxysulfur radicals, viz.,
SO3−, SO4−, and SO5− operates. Addition of ethanol leads to the introduction of an induction period and decrease in reaction rate, most likely
due to scavenging of SO4− radicals. The value of apparent energy of activation is 45.4 kJ mol−1. 相似文献
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This Letter presents an investigation of the excitation of an upper hybrid wave (UHW) by cross focusing of two intense laser beams in a collisionless hot magnetoplasma, when relativistic and ponderomotive nonlinearities are operative. The electric vectors of the two beams are polarized along uniform static magnetic field and the beams propagate perpendicular to the static magnetic field. Analytical expressions for the beam width of the laser beams, electric vector and power of the excited UHW and energy gain have been obtained. The UHW generation at the difference frequency and particle acceleration has also been studied. The nonlinear coupling between intense laser beams and UHW is so strong that UHW gets excited and a large fraction of the laser beam energy gets transferred to UHW and this UHW accelerates electrons. It has been shown that the presence of a magnetic field affects significantly the power of the UHW and energy gain by the electron in the presence of the UHW. 相似文献
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Prerana B. Jadhav Shailaja B. Jadhav Mehrukh Zehravi Mohammad S. Mubarak Fahadul Islam Philippe Jeandet Sharuk L. Khan Nazmul Hossain Salma Rashid Long Chiau Ming Md. Moklesur Rahman Sarker Mohd Fahami Nur Azlina 《Molecules (Basel, Switzerland)》2023,28(1)
Dipeptidyl peptidase-4 (DPP-IV) inhibitors are known as safe and well-tolerated antidiabetic medicine. Therefore, the aim of the present work was to synthesize some carbohydrazide derivatives (1a–5d) as DPP-IV inhibitors. In addition, this work involves simulations using molecular docking, ADMET analysis, and Lipinski and Veber’s guidelines. Wet-lab synthesis was used to make derivatives that met all requirements, and then FTIR, NMR, and mass spectrometry were used to confirm the structures and perform biological assays. In this context, in vitro enzymatic and in vivo antidiabetic activity evaluations were carried out. None of the molecules had broken the majority of the drug-likeness rules. Furthermore, these molecules were put through additional screening using molecular docking. In molecular docking experiments (PDB ID: 2P8S), many molecules displayed more potent interactions than native ligands, exhibiting more hydrogen bonds, especially those with chloro- or fluoro substitutions. Our findings indicated that compounds 5b and 4c have IC50 values of 28.13 and 34.94 µM, respectively, under in vitro enzymatic assays. On the 21st day of administration to animals, compound 5b exhibited a significant reduction in serum blood glucose level (157.33 ± 5.75 mg/dL) compared with the diabetic control (Sitagliptin), which showed 280.00 ± 13.29 mg/dL. The antihyperglycemic activity showed that the synthesized compounds have good hypoglycemic potential in fasting blood glucose in the type 2 diabetes animal model (T2DM). Taken all together, our findings indicate that the synthesized compounds exhibit excellent hypoglycemic potential and could be used as leads in developing novel antidiabetic agents. 相似文献