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121.
Ma Y Luciani T Porter RA Russell AT Johnson D Marston G 《Physical chemistry chemical physics : PCCP》2007,9(37):5084-5087
The mechanism of formation of pinonic and norpinonic acids from alpha-pinene ozonolysis has been investigated by studying the products of the ozonolysis of an enone derived from alpha-pinene using gas chromatography coupled to mass spectrometry. 相似文献
122.
This Highlight covers the chemical ecology of bryozoans, primarily the ecological functions of bryozoan natural products. The Highlight is arranged taxonomically, according to the bryozoan Treatise classification (P. Bock, Bryozoa Homepage, 2006, http://bryozoa.net). 相似文献
123.
Point D Davis WC Christopher SJ Ellisor MB Pugh RS Becker PR Donard OF Porter BJ Wise SA 《Analytical and bioanalytical chemistry》2007,387(7):2343-2355
An accurate, ultra-sensitive and robust method for speciation of mono, di, and tributyltin (MBT, DBT, and TBT) by speciated isotope-dilution gas chromatography-inductively coupled plasma-mass spectrometry (SID-GC-ICPMS) has been developed for quantification of butyltin concentrations in cryogenic biological materials maintained in an uninterrupted cryo-chain from storage conditions through homogenization and bottling. The method significantly reduces the detection limits, to the low pg g(-1) level (as Sn), and was validated by using the European reference material (ERM) CE477, mussel tissue, produced by the Institute for Reference Materials and Measurements. It was applied to three different cryogenic biological materials-a fresh-frozen mussel tissue (SRM 1974b) together with complex materials, a protein-rich material (whale liver control material, QC03LH03), and a lipid-rich material (whale blubber, SRM 1945) containing up to 72% lipids. The commutability between frozen and freeze-dried materials with regard to spike equilibration/interaction, extraction efficiency, and the absence of detectable transformations was carefully investigated by applying complementary methods and by varying extraction conditions and spiking strategies. The inter-method results enabled assignment of reference concentrations of butyltins in cryogenic SRMs and control materials for the first time. The reference concentrations of MBT, DBT, and TBT in SRM 1974b were 0.92 +/- 0.06, 2.7 +/- 0.4, and 6.58 +/- 0.19 ng g(-1) as Sn (wet-mass), respectively; in SRM 1945 they were 0.38 +/- 0.06, 1.19 +/- 0.26, and 3.55 +/- 0.44 ng g(-1), respectively, as Sn (wet-mass). In QC03LH03, DBT and TBT concentrations were 30.0 +/- 2.7 and 2.26 +/- 0.38 ng g(-1) as Sn (wet-mass). The concentration range of butyltins in these materials is one to three orders of magnitude lower than in ERM CE477. This study demonstrated that cryogenically processed and stored biological materials are a promising alternative to conventional freeze-dried materials for organotin speciation analysis, because these are, at present, the best conditions for minimizing degradation of thermolabile species and for long-term archival. Finally, the potential of the analytical method was illustrated by analysis of polar bear (Ursus maritimus) and beluga whale (Delphinapterus leuca) liver samples that had been collected in the Arctic and archived at the Marine Environmental Specimen Bank. Significant concentrations of butyltin compounds were found in the samples and provide the first evidence of the presence of this class of contaminant in the Arctic marine ecosystem. Figure Eye catch image. 相似文献
124.
Davis WC Christopher SJ Pugh RS Donard OF Krupp EA Point D Horvat M Gibicar D Kljakovic-Gaspic Z Porter BJ Schantz MM 《Analytical and bioanalytical chemistry》2007,387(7):2335-2341
This paper describes the development of two independent analytical methods for the extraction and quantification of methylmercury
from marine biota. The procedures involve microwave extraction, followed by derivatization and either headspace solid-phase
microextraction (SPME) with a polydimethylsiloxane (PDMS)-coated silica fiber or back-extraction into iso-octane. The identification
and quantification of the extracted compounds is carried out by capillary gas chromatography/mass spectrometric (GC/MS) and
inductively coupled plasma mass spectrometric (GC/ICP-MS) detection. Both methods were validated for the determination of
methylmercury (MeHg) concentrations in a variety of biological standard reference materials (SRMs) including fresh-frozen
tissue homogenates of SRM 1946 Lake Superior fish tissue and SRM 1974a organics in mussel tissue (Mytilus edulis) and then applied to the certification effort of SRM 1947 Lake Michigan fish tissue and SRM 1974b organics in mussel tissue
(Mytilus edulis). While past certifications of methylmercury in tissue SRMs have been based on two independent methods from the National
Institute of Standards and Technology (NIST) and participating laboratories, the methods described within provide improved
protocols and will allow future certification efforts to be based on at least two independent analytical methods within NIST. 相似文献
125.
Yin H Chacon A Porter NA Masterson DS 《Journal of the American Society for Mass Spectrometry》2007,18(5):807-816
Protein identification is routinely accomplished by peptide sequencing using mass spectrometry (MS) after enzymatic digestion.
Site-specific chemical modification may improve peptide ionization efficiency or sequence coverage in mass spectrometry. We
report herein that amino group of lysine residue in peptides can be selectively modified by reaction with a peroxycarbonate
and the resulting lysine peroxycarbamates undergo homolytic fragmentation under conditions of low-energy collision-induced
dissociation (CID) in electrospray ionization (ESI) and matrix-assisted laser desorption and ionization (MALDI) MS. Selective
modification of lysine residue in peptides by our strategy can induce specific peptide cleavage at or near the lysine site.
Studies using deuterated analogues of modified lysine indicate that fragmentation of the modified peptides involves apparent
free-radical processes that lead to peptide chain fragmentation and side-chain loss. The formation of a-, c-, or z-types of
ions in MS is reminiscent of the proposed free-radical mechanisms in low-energy electron capture dissociation (ECD) processes
that may have better sequence coverage than that of the conventional CID method. This site-specific cleavage of peptides by
free radical- promoted processes is feasible and such strategies may aid the protein sequencing analysis and have potential
applications in top-down proteomics. 相似文献
126.
Transcellular diffusion across the absorptive epithelial cells (enterocytes) of the small intestine is the main route of absorption for most orally administered drugs. The process by which lipophilic compounds transverse the aqueous environment of the cytoplasm, however, remains poorly defined. In the present study, we have identified a structurally diverse group of lipophilic drugs that display low micromolar binding affinities for a cytosolic lipid-binding protein - intestinal fatty acid-binding protein (I-FABP). Binding to I-FABP significantly enhanced the transport of lipophilic drug molecules across a model membrane, and the degree of transport enhancement was related to both drug lipophilicity and I-FABP binding affinity. These data suggest that intracellular lipid-binding proteins such as I-FABP may enhance the membrane transport of lipophilic xenobiotics and facilitate drug access to the enterocyte cytoplasm and cytoplasmic organelles. 相似文献
127.
Hong J Porter DW Sreenivasan R McIntyre PC Bent SF 《Langmuir : the ACS journal of surfaces and colloids》2007,23(3):1160-1165
A new process of applying molecular resists to block HfO2 and Pt atomic layer deposition has been investigated. Monolayer films are formed from octadecyltrichlorosilane (ODTS) or tridecafluoro-1,1,2,2-tetrahydrooctyltrichlorosilane (FOTS) and water vapor on native silicon oxide surfaces and from 1-octadecene on hydrogen-passivated silicon surfaces through a low-pressure chemical vapor deposition process. X-ray photoelectron spectroscopy data indicates that surfaces blocked by these monolayer resists can prevent atomic layer deposition of both HfO2 and Pt successfully. Time-dependent studies show that the ODTS monolayers continue to improve in blocking ability for as long as 48 h of formation time, and infrared spectroscopy measurements confirm an evolution of packing order over these time scales. 相似文献
128.
The reaction of a variety of sulphur nucleophiles [thiourea, S-ethyl mercaptoethylamine (EMEA), glutathione (GSH), dimethylsulphoxide (DMSO) and methionine] with the platinum(II) complex [Pt(dien)Cl]+ has been studied at 25°C using the nucleophiles in large excess. The measurements confirm that the sulphur nucleophiles react directly with the platinum complex and that the solvolytic pathway makes little contribution to the reaction. The reactions were monitored by a combination of conductometric and spectrophotometric methods. The oxygen and nitrogen nucleophiles water and imidazole respectively have also been studied. Reagents such as thiourea, EMEA, methionine and glutathione are some 101–102 more reactive than the nitrogen nucleophile imidazole and some 102–103 more reactive than oxygen nucleophile. In a direct competition between sulphur (kS) and nitrogen (kN) nucleophiles for the platinum substrate, as will occur under biological conditions, the kS/kN ratio is at least 10 so that little of the nitrogen-substituted product will be formed in the reaction. 相似文献
129.
This research extends previous studies regarding the application of supercritical fluid extraction (SFE) for the analysis of oligomers from nylon 6,6 fibers. The effects of CO2 pressure, extraction temperature, CO2-modifier percentage, static extraction time and dynamic extraction time on the SFE efficiency of nylon 6,6 oligomers were examined. Results from the SFE methods for oligomer extractions were compared to results from conventional solvent extraction. The extracted oligomers were identified by high-performance liquid chromatography (HPLC) with coupled on-line atmospheric pressure chemical ionization mass spectrometry and HPLC fractionation coupled with off-line liquid secondary ion mass spectrometry. 相似文献
130.
Jason M. Porter Jay B. Jeffries Ronald K. Hanson 《Journal of Quantitative Spectroscopy & Radiative Transfer》2009,110(18):2135-2147
Quantitative absorption spectra for several hydrocarbon fuels in the liquid phase at are presented. Measurements of toluene, n-dodecane, n-decane, and three samples of gasoline were made over the spectral region 2700–3200 to support the development of mid-infrared laser-absorption diagnostics for measurements of fuel vapor in the presence of liquid films and aerosols. A procedure for quantitative Fourier transform infrared (FTIR) absorption measurements of strongly absorbing liquids is described and the resulting absorption spectra are compared with previously measured absorption spectra in the vapor phase. The measured absorption spectra for liquid gasoline are shown to scale with the volume percent of olefin, alkane, and aromatic hydrocarbons in each sample. Finally, the observed frequency shift of in the spectra of vapor and liquid hydrocarbons is discussed, including the potential for measurements of fuel vapor in the presence of liquid films. 相似文献