Synthesis of a novel copolymer using glycogen and poly(lactide) as a carrier of dual drugs—ornidazole and ofloxacin

Biodegradability and biocompatibility are two crucial prerequisites for a promising therapeutic vehicle. Herein, a novel biocompatible copolymer has been synthesized using glycogen and polylactide (PLA). Glycogen, a naturally occurring biopolymer has been functionalized by methacrylation. On the other hand, lactide has been polymerized through ring opening polymerization (ROP), initiated by hydroxyethyl methacrylate (HEMA) and catalyzed by tin (II) 2‐ethyl hexanoate. Finally, the synthesized two substrates (i.e., glycogen methacrylate and PLA‐HEMA) are covalently connected by free‐radical polymerization, initiated by AIBN. The structure of the developed copolymer has been confirmed using ¹H and ¹³C NMR spectral analyses. The gel characteristics have been evaluated by rheological studies, while the morphological assessment has been investigated by FESEM analysis. In vitro cytocompatibility study reveals that the hydrogel (Gly‐co‐PLA) is biocompatible. The in vitro and in vivo release studies demonstrate the excellent pH‐sensitive control release profile of dual drugs: ornidazole and ofloxacin. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1697–1703     

Isotopic effects on non-linearity, molecular radius and intermolecular free length

Computation of non-linearity parameter (B/A), molecular radius (r _m) and intermolecular free length (L _f) for H₂O, C₆H₆, C₆H₁₂, CH₃OH, C₂H₅OH and their deuterium-substituted compounds have been carried out at four different temperatures, viz., 293.15, 303.15, 313.15 and 323.15 K. The aim of the investigation is an attempt to study the isotopic effects on the non-linearity parameter and the physicochemical properties of the liquids, which in turn has been used to study their effect on the intermolecular interactions produced thereof.     

Applicability of Reddish-Orange Light Emitting Samarium (III) Complexes for Biomedical and Multifunctional Optoelectronic Devices

Six crimson samarium (III) complexes based on β-ketone carboxylic acid and ancillary ligands were synthesized by adopting the grinding technique. All synthesized complexes were investigated via elemental analysis, infrared, UV–Vis, NMR, TG/DTG and photoluminescence studies. Optical properties of these photostimulated samarium (III) complexes exhibit reddish-orange luminescence due to ⁴G_5/2?→?⁶H_7/2 electronic transition at 606 nm of samarium (III) ions. Further, energy bandgap, color purity, CIE color coordinates, CCT and quantum yield of all complexes were determined accurately. Replacement of water molecules by ancillary ligands enriched these complexes (S2-S6) with decay time, quantum yield, luminescence, energy bandgap and biological properties than parent complex (S1). Interestingly, these efficient properties of complexes may find their applications in optoelectronics and lighting systems. In addition to these, the antioxidant and antimicrobial assays were also investigated to explore the applications in biological assays.

     

Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Cyanobacteria (blue-green microalgae) are ubiquitous, Gram-negative photoautotrophic prokaryotes. They are considered as one of the most efficient sources of bioactive secondary metabolites. More than 50% of cyanobacteria are cultivated on commercial platforms to extract bioactive compounds, which have bene shown to possess anticancer activity. The chemically diverse natural compounds or their analogues induce cytotoxicity and potentially kill a variety of cancer cells via the induction of apoptosis, or altering the activation of cell signaling, involving especially the protein kinase-C family members, cell cycle arrest, mitochondrial dysfunctions and oxidative damage. These therapeutic properties enable their use in the pharma and healthcare sectors for the betterment of future generations. This review provides a baseline overview of the anti-cancerous cyanobacterial bioactive compounds, along with recently introduced nanomaterials that could be used for the development of new anticancer drugs to build a healthy future for mankind.     

Palladium acetate assisted synthesis of five-membered N-polyheterocycles

Abstract

The metal-assisted synthesis of heterocyclic compounds is known to be one of the extremely developing as well as significant concepts of organic chemistry. Because of their expensive, complex working of the instrument and difficult procedures, the methodologies used earlier for the heterocycle synthesis were less amicable to the researchers. The Pd(OAc)₂-mediated cyclic reactions have been recognized to be very effective for both the stereoselective as well as regioselective formation of the 5-membered N-bearing heterocyclic compounds. The different uses of palladium acetate, as a catalyst in the formation of 5-membered N-containing polyheterocycles, are covered in this review article.     

Estimation of betulinic acid from wild fruit extracts of Ziziphus mauritiana and Ziziphus nummularia from different regions of North India by a validated high-performance thin-layer chromatography method

JPC – Journal of Planar Chromatography – Modern TLC - The Ziziphus fruits are recognized as a rich source of biologically active compounds, such as polysaccharides, phenolics,...     

Performance evaluation of the phase encoded optical CDMA system

Recently, there has been increasing interest in field of Optical CDMA due to its potential for offering unmatched features at ultra high data rates in field of local and metro area networks. In this paper, a very simple method of Optical CDMA encoding known as the Temporal Phase Encoding is discussed and the performance of the system with this encoding technique is evaluated on the basis of number of users, length of the spreading code for 4-phase and 8-phases. Simulation results for the system are presented for upto seven users. Bit error rate curves are plotted with data rate of 1 Gbps. This has been found that performance improves if normalized threshold higher than 0.5 is used.