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71.
Both C(2)-P bond breaking and formation in the S-C-P(+) system do not occur according to the antiperiplanar lone pair hypothesis. Experiments using 2-phosphonio derivatives of 5-tert-butyl-1,3-dithiane and cis-4,6-dimethyl-1,3-dithiane are against the participation of higher-energy boat conformers as reactive intermediates. The results obtained support a possibility of conformational adjustment in the course of the reaction. Stereoelectronic control of the C(2)-P bond breaking and formation results from interplay of several factors. The role of the n(S)-sigma(C(2))(-)(P) and sigma(C(4,6))(-)(S)-sigma(C(2))(-)(P) hyperconjugation, as well as of the repulsive interactions between lone electron pairs pi(S) of endocyclic sulfur atoms and pi-electrons of the phenyl ring(s) connected with phosphorus, is discussed. 相似文献
72.
Małgorzata Olejnik Teresa Szprengier-Juszkiewicz Piotr Jedziniak Jan Żmudzki 《Accreditation and quality assurance》2007,12(12):637-641
In this paper, the case of FAPAS PT 0270 “Doramectin and Oxfendazole in Sheep Liver” is discussed. During evaluation of the
data received from participants (determination of total, oxidised oxfendazole residue and calculation of the sum of oxfendazole
and oxfendazole sulfone residues), significant differences were observed between the results obtained by use of two analytical
approaches. This phenomenon can be explained by the route of oxfendazole metabolism, which results in the presence of fenbendazole
in the sample. This was not predicted by the provider; consequently, not all the necessary tests on the material were conducted.
Due to the high uncertainty of the z-scores in this test, the results of the PT cannot be used for purposes of evaluation, and the benefits of participation in
PT 0270 are questionable. 相似文献
73.
74.
Owczarek E Kwiatkowski W Lemieszewski M Mazur A Rostkowski M Paneth P 《The Journal of organic chemistry》2003,68(21):8232-8235
Nitrogen, deuterium, halogen, and carbon kinetic isotope effects have been modeled for the Menshutkin reaction between methyl halides and substituted N,N-dimethylaniline at the HF/6-31G(d) level of theory augmented by the C-PCM continuum solvent model for several solvents. Systematic changes in geometries of the transition states and Gibbs free energies of activation have been found with phenyl ring substituents, solvent, and the leaving group. Kinetic isotope effects also change systematically; however, these changes are predicted to be small, inside the usual precision of the experimental measurements. On the contrary, no correlation has been found between the kinetic isotope effects and the Hammett constants for para substituents. Thus opposite to previous assumptions, our results indicate that kinetic isotope effects on the Menshutkin reaction cannot be used to predict the position of the transition state on the reaction coordinate. 相似文献
75.
The fragmentation patterns of the thioacyl derivatives of 2-aminothiazole and 2-aminobenzothiazole and of their ‘fixed structure’ imino and amino tautomeric forms give evidence of the predominance of the imino tautomer in the molecular ions of the trifluorothioacetyl compounds. On the other hand, the M+˙ ions of the thioacetyl and thiobenzoyl derivatives are mainly the amino tautomers. A rearrangement with elimination of RCN and formation of the 2-thiazolothione (2-benzothiazolothione) ion is characteristic for ail the compounds investigated. Additional evidence for the interpretation of the main fragmentation paths is provided by the mass spectra of the N-trideuteromethyl and N-deuterated derivatives, high-resolution mass spectrometry being used to determine the elemental composition of some selected peaks. 相似文献
76.
Lucjan Chmielarz Piotr Kustrowski Marek Michalik Barbara Dudek Magdalena Czajka Roman Dziembaj 《Reaction Kinetics and Catalysis Letters》2007,91(2):369-378
Natural phlogophite, pre-treated with acids and intercalated with alumina pillars, was used as catalytic support. Transition
metals (Fe, Cu) were deposited on the surface of the modified clay materials by an ion-exchange method. The obtained samples
were characterized with respect to structure (XRD), texture (BET), composition (EPMA) and chemical nature of the deposited
transition metals species (UV-vis-DRS). The phlogophite based materials have been found to be active and selective catalysts
of the DeNOx process. The Fe-containing samples were catalytically active at lower temperatures than the clays modified with
copper. A competitive ammonia oxidation by oxygen decreased the effectiveness of the DeNOx process in the high temperature
range. 相似文献
77.
Piotr Król Bożena Król Stanisław Pikus Maciej Kozak 《Colloid and polymer science》2006,285(2):169-175
Small angle X-ray scattering and differential scanning calorimetry methods were employed to characterise the internal order of structural phases present in polyurethane coatings obtained as a result of water evaporation from anionomer dispersions. Those anionomers were produced in the reaction of aromatic, cycloaliphatic and aliphatic diisocyanates with polyoxyethylene glycol, 2,2-bis-(hydroxymethyl)propionic acid and 1,6-hexamethylenediamine. The decisive effects were found from ionic and polar structures within the rigid urethane and urea segments on the ordered arrangement degree of the supermolecular structures in the obtained anionomers. That becomes apparent in differential scanning calorimetry thermograms and contributes to improved thermal stability of the produced polyurethane coatings. 相似文献
78.
A new, accurate, sensitive and fast reversed-phase high-performance liquid chromatography (RP-HPLC) as an analytical method for the quantitative determination of 11 drugs in human urine was worked out, optimized and validated. The objects of analysis were imipenem (IMP), paracetamol (PAR), dipyrone (DPR), vancomycin (VCM), amikacin (AMK), fluconazole (FZ), cefazolin (CFZ), prednisolone (PRE), dexamethasone (DEX), furosemide (FUR) and ketoprofen (KET) belonging to four different groups (antibiotics, analgesic, demulcent and diuretic). For HPLC analysis, diode array (DAD) and fluorescence (FL) detectors were used. The separation of analyzed compounds was conducted by means of a LiChroCART® Purospher® C18e (125 mm × 3 mm, particle size 5 μm) analytical column with LiChroCART® LiChrospher® C18 (4 mm × 4 mm, particle size 5 μm) pre-column with gradient elution. Analyzed drugs were determined within 20 min. The mobile phase was comprised of various proportions of methanol, acetonitrile and 0.05% trifluoroacetic acid in water. AMK was separated and determined from human urine using ortho-phthaldialdehyde-3-mercaptopropionic acid (OPA-3-MPA) as a fluorescent reagent by RP-HPLC-FL. The following retention times for drugs IMP, PAR, DPR, VCM, AMK, FZ, CFZ, PRE, DEX, FUR and KET in human urine were found: 4.01 min, 4.86 min, 6.71 min, 8.14 min, 9.46 min, 10.01 min, 10.90 min, 13.34 min, 14.06 min, 16.03 min and 18.98 min, respectively. Excellent linearity was obtained for compounds in the range of concentration: 0.35-42 μg ml−1, 0.5-45 μg ml−1, 4.5-38 μg ml−1, 0.25-25 μg ml−1, 0.5-35 μg ml−1, 0.25-22 μg ml−1, 0.03-52 μg ml−1, 0.15-25 μg ml−1, 0.25-28 μg ml−1, 0.05-18 μg ml−1 and 0.15-35 μg ml−1 for IMP, PAR, DPR, VCM, AMK, FZ, CFZ, PRE, DEX, FUR and KET, respectively. The limits of detection (LOD) and limits of quantification (LOQ) for analyzed drugs were calculated in all cases and recovery studies were also performed. Ten human urine samples obtained from patients treated in hospital have been tested. In analyzed samples, one or more drugs from the 11 examined drugs were detected. The concentrations of examined drugs in urine samples ranged between: 1.5-12 μg ml−1 of PAR, 5.2-11.5 μg ml−1 of DPR, 0.13-9.5 μg ml−1 of CFZ and 0.1-8 μg ml−1 of FUR. This method can be successfully applied to routine determination of all these drugs in human urine samples. 相似文献
79.
Lucjan B. Jerzykiewicz Jzef Utko Piotr Sobota 《Acta Crystallographica. Section C, Structural Chemistry》2007,63(11):m501-m503
The molecule of the title compound, [Mn4Al(CH3)2(C3H7O2)4I5(C4H8O)], contains one AlIII and four MnII ions. Two Mn atoms are five‐coordinate in the form of a trigonal bipyramid or a square pyramid. The two other Mn atoms are six‐coordinate with an octahedral geometry. The fourcoordinate Al atom is linked to the manganese core by μ‐Oalkoxo bridges, forming an almost planar five‐membered ring. 相似文献
80.
Ewa Machalska Grzegorz Zajac Malgorzata Baranska Dorota Kaczorek Robert Kawcki Piotr F. J. Lipiski Joanna E. Rode Jan Cz. Dobrowolski 《Chemical science》2021,12(3):911
Raman optical activity (ROA) spectra recorded for a chiral naphthalene diimide derivative (nBu-NDI–BINAM) dissolved in a series of solvents exhibit strong solute to solvent induced chirality with: (1) dominating bands of solvents, (2) nBu-NDI–BINAM resonance ROA (RROA) bands which are barely visible, (3) monosignate RROA Solvent spectra with an unexpected sign concordant with that of the ECD band of the resonant electronic state, (4) bisignate RROA bands for a few solvents, and (5) superposition of non-resonant and resonant ROA bands of the chiral solvents. The unusual ROA enhancement was explained in terms of resonance energy transfer with resonant Raman emission. The surprising RROA sign-switching was found to be due to specific conformational equilibria where one solute conformer dominates in the ground and the other in the first excited singlet state, and, the signs of the related ECD bands of these two conformers are opposite.Unusual solute to solvent induced chirality in ROA comes from specific conformer equilibria in the ground and the excited states. 相似文献