Lagrangian temperature, velocity, and local heat flux measurement in Rayleigh-Bénard convection

We have developed a small, neutrally buoyant, wireless temperature sensor. Using a camera for optical tracking, we obtain simultaneous measurements of position and temperature of the sensor as it is carried along by the flow in Rayleigh-Bénard convection, at Ra approximately 10;{10}. We report on statistics of temperature, velocity, and heat transport in turbulent thermal convection. The motion of the sensor particle exhibits dynamics close to that of Lagrangian tracers in hydrodynamic turbulence. We also quantify heat transport in plumes, revealing self-similarity and extreme variations from plume to plume.     

Subcritical dynamo bifurcation in the Taylor-Green flow

We report direct numerical simulations of dynamo generation for flow generated using a Taylor-Green forcing. We find that the bifurcation is subcritical and show its bifurcation diagram. We connect the associated hysteretic behavior with hydrodynamics changes induced by the action of the Lorentz force. We show the geometry of the dynamo magnetic field and discuss how the dynamo transition can be induced when an external field is applied to the flow.     

Unsymmetric Cisplatin-Based Pt(IV) Conjugates Containing a PARP-1 Inhibitor Pharmacophore Tested on Malignant Pleural Mesothelioma Cell Lines

Cisplatin is widely employed as a first-line chemotherapeutic agent for many solid tumors, including malignant pleural mesothelioma (MPM). However, its clinical use is limited by heavy side effects and acquired resistance, the latter being mainly related to enhanced DNA repair. Many clinical trials using combinations of platinum drugs and PARP-1 inhibitors (PARPis) have been carried out, with the hope that such combinations might lead to improved therapeutic efficacy against tumors. Here, the synthesis and efficacy in reducing MPM cell viability of four cisplatin-based Pt(IV) prodrugs containing the PARPi 3-aminobenzamide (3-ABA) fragment are described. The most promising conjugate is more effective than cisplatin or cisplatin/3-ABA combination, administered in equimolar doses, in inhibiting PARP-1 activity and inducing apoptosis in BRCA1/2 wild type MPM cells, grown as monolayer or as multicellular spheroids.     

Temporal variations of iodine-127, potassium-40 and technetium-99 concentrations in Fucus serratus in the English Channel

The trends of¹²⁷I,⁴⁰K, and⁹⁹Tc levels were measured for several years inFucus serratus collected in 3 different Channel coastal stations. The results demonstrated cyclic seasonal variations of the levels, with maximum values in winter and minimum values in summer (ranging between 2 and 3). Ash levels evolved with a similar cycle, which allowed to estimate that the cycle thus observed was related to the alga biological activity and not to the releases. Trends of⁹⁹Tc levels were more complex. At Roscoff, a station little exposed to the releases, levels varied with the same annual cycle as natural elements. At Herquemoulin, a station close to the release point, the trend was mainly related to the released activities with a delay of about 1 year. At Wimereux, a distant station more strongly affected by sea currents, the cycle appeared in 1983 and 1984 but was hidden in 1985 and 1986 by the arrival of waters more strongly labelled because of the larger releases that occurred in 1985 (26 TBq), instead of 12 TBq in 1983 and 1984.     

Reflectance Confocal Microscopy for In Vivo Skin Imaging†

Reflectance confocal microscopy (RCM) is a novel noninvasive technique for “in vivo” examination of the skin. In a confocal microscope, near‐ infrared light from a diode laser is focused on a microscopic skin target. As this light passes between cellular structures having different refraction indexes, it is naturally reflected, and this reflected light is then captured and recomposed into a two‐dimensional gray scale image by computer software. Focusing the microscope (adjusting the focal point on the z‐axis) allows images to be obtained of different levels within the skin. Commercially available microscope systems of this type can create images with enough detail for use in histological analysis. The first investigations using these microscopes served to identify the appearance of the various cell populations living in the different layers of normal skin. Today, the main interest has become focused on the use of these microscopes as a diagnostic tool: a means of investigating benign and malignant tumors of melanocytes and keratinocytes, and, more importantly, the findings of this field of study can be used to develop a diagnostic algorithm which would be not only highly sensitive but specific as well. The aim of the paper is to provide an updated literature review and an in‐depth critique of the state‐of‐the‐art of RCM for skin cancer imaging with a critical discussion of the possibilities and limitations for clinical use.