Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat

Background  

The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were studied in urethane anaesthetized rats. The epileptic activity of the dentate gyrus was obtained through the repetitive stimulation of the angular bundle and maximal dentate gyrus activation latency, duration and post-stimulus afterdischarge duration were evaluated.     

Combining halogen bonds and hydrogen bonds in the modular assembly of heteromeric infinite 1-D chains

Hydrogen bonds and halogen bonds operate in concert in the directed assembly of infinite 1-D chains in binary co-crystals of iodine iso-nicotinamide (2 : 2), 1 and tetrafluorodiiodobenzene iso-nicotinamide (1 : 2) 2.     

An integral representation approach for valuing American-style installment options with continuous payment plan

In this paper, we present an integral equation approach for the valuation of American-style installment derivatives when the payment plan is assumed to be a continuous function of the asset price and time. The contribution of this study is threefold. First, we show that in the Black-Scholes model the option pricing problem can be formulated as a free boundary problem under very general conditions on payoff structure and payment schedule. Second, by applying a Fourier transform-based solution technique, we derive a system of coupled recursive integral equations for the pair of free boundaries along with an analytic representation of the option price. Third, based on these results, we propose a unified framework which generalizes the existing methods and is capable of dealing with a wide range of monotonic payoff functions and continuous payment plans. Finally, by using the illustrative example of American vanilla installment call options, an explicit pricing formula is obtained for time-varying payment schedules.     

Multinuclear Solid‐State Magnetic Resonance as a Sensitive Probe of Structural Changes upon the Occurrence of Halogen Bonding in Co‐crystals

Although the understanding of intermolecular interactions, such as hydrogen bonding, is relatively well‐developed, many additional weak interactions work both in tandem and competitively to stabilize a given crystal structure. Due to a wide array of potential applications, a substantial effort has been invested in understanding the halogen bond. Here, we explore the utility of multinuclear (¹³C, ^14/15N, ¹⁹F, and ¹²⁷I) solid‐state magnetic resonance experiments in characterizing the electronic and structural changes which take place upon the formation of five halogen‐bonded co‐crystalline product materials. Single‐crystal X‐ray diffraction (XRD) structures of three novel co‐crystals which exhibit a 1:1 stoichiometry between decamethonium diiodide (i.e., [(CH₃)₃N⁺(CH₂)₁₀N⁺(CH₃)₃][2 I^?]) and different para‐dihalogen‐substituted benzene moieties (i.e., p‐C₆X₂Y₄, X=Br, I; Y=H, F) are presented. ¹³C and ¹⁵N NMR experiments carried out on these and related systems validate sample purity, but also serve as indirect probes of the formation of a halogen bond in the co‐crystal complexes in the solid state. Long‐range changes in the electronic environment, which manifest through changes in the electric field gradient (EFG) tensor, are quantitatively measured using ¹⁴N NMR spectroscopy, with a systematic decrease in the ¹⁴N quadrupolar coupling constant (C_Q) observed upon halogen bond formation. Attempts at ¹²⁷I solid‐state NMR spectroscopy experiments are presented and variable‐temperature ¹⁹F NMR experiments are used to distinguish between dynamic and static disorder in selected product materials, which could not be conclusively established using solely XRD. Quantum chemical calculations using the gauge‐including projector augmented‐wave (GIPAW) or relativistic zeroth‐order regular approximation (ZORA) density functional theory (DFT) approaches complement the experimental NMR measurements and provide theoretical corroboration for the changes in NMR parameters observed upon the formation of a halogen bond.     

A closed loop experiment of collective bounce aeroelastic Rotorcraft–Pilot Coupling

This work presents an experimental study that investigated the possibility of destabilising a rotorcraft by coupling the biomechanical behaviour of human subjects with the dynamics of the vehicle. The results of a study focused on the behaviour of pilots holding the collective control inceptor in a flight simulator are discussed. The motion of the flight simulation model was restricted to the heave axis, and augmented to include an elastic mode of vibration in addition to the rigid heave degree of freedom. Four different pilots flew several alternative model configurations with different elastic mode frequency and different collective pitch gearing ratios. This resulted in several observable unstable pilot–vehicle interactions at frequencies that cannot be traced back to the rotorcraft dynamics. Unstable oscillatory events evolving into limit cycle oscillations occurred most often at frequencies related to the biomechanics of the flight simulator occupant. They appeared to be task dependent and, in some cases, the trigger could be attributed to specific events. Additionally, it was found that the presence of collective friction alleviates but does not completely eliminate the unstable interactions between the pilot and the rotorcraft. Although not statistically meaningful because of the small set of human subjects available for the study, the results confirmed that the biomechanics transfer function of the pilot is the most influential aspect of the pilot–vehicle system that gives rise to the adverse vertical bounce phenomenon. Additionally, this study gave useful insight into the vehicle parameters that can adversely influence the involuntary interaction of pilots with rotorcraft.     

An aromatic coupling motif for two-dimensional supramolecular architectures

We show, using scanning tunneling microscopy, how a coupling motif based on self-complementary helical aromatic units is able to drive the formation of a chiral porous supramolecular network and chains based on lateral aromatic interactions in two dimensions.     

2-Iodo-imidazolium receptor binds oxoanions via charge-assisted halogen bonding

A detailed (1)H-NMR study of the anion binding properties of the 2-iodo-imidazolium receptor 1 in DMSO allows to fully attribute the observed affinities to strong charge-assisted C-I···X(-) halogen bonding (XB). Stronger binding was observed for oxoanions over halides. Phosphate, in particular, binds to 1 with an association constant of ca. 10(3) M(-1), which is particularly high for a single X-bond. A remarkably short C-I···O(-) contact is observed in the structure of the salt 1·H(2)PO(4)(-).     

Improved methodology for the preparation of water-soluble maleimide-functionalized small gold nanoparticles

Improved methodology to prepare maleimide-functionalized, water-soluble, small (<3 nm) gold nanoparticles using a retro-Diels-Alder strategy that we developed for similar organic-soluble AuNP's is described. Importantly, our results suggest that a recent paper by Zhu, Waengler, Lennox, and Schirrmacher describing a similar strategy gave results inconsistent with the formation of the titled maleimide-modified AuNP (Zhu, J.; Waengler, C.; Lennox, R. B.; Schirrmacher, R. Langmuir2012, 28, 5508) as the major product, but consistent with the major product being an adduct derived from the hydrolysis of maleimide formed under the conditions used for the required deprotection of the maleimide. Our methodology provides an efficient and accessible route to pure maleimide-modified small AuNP's that circumvents the formation of the hydrolysis product. The maleimide-modified small AuNP's are versatile because they are soluble in water and in a wide range of organic solvents and their reactivity can now be properly exploited as a reactive moiety in Michael addition for bioconjugation studies in aqueous solution.     

Hydrogen and halogen bonding drive the orthogonal self-assembly of an organic framework possessing 2D channels

Orthogonal self-assembly of an open organic framework showing 2D channels has been obtained by combining hydrogen and halogen bonding. The framework is able to host various guest molecules with a diverse set of steric demands and substitution patterns, and survives single-crystal-to-single-crystal guest exchanges from liquid and gas phases.