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961.
Min Kim Changhu Lee Dae Yun Seo Hyojung Lee Jay D. Horton Jiyoung Park Philipp E. Scherer 《Experimental & molecular medicine》2020,52(10):1766
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and can lead to multiple complications, including non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. The fibrotic liver is characterized by the pathological accumulation of extracellular matrix (ECM) proteins. Type VI collagen alpha3 (Col6a3) is a biomarker of hepatic fibrosis, and its cleaved form, endotrophin (ETP), plays a critical role in adipose tissue dysfunction, insulin resistance, and breast cancer development. Here, we studied the effects of the Col6a3-derived peptide ETP on the progression of chronic liver diseases, such as NASH and liver cancer. We used a doxycycline (Dox)-inducible liver-specific ETP-overexpressing mouse model on a NAFLD-prone (liver-specific SREBP1a transgenic) background. For this, we evaluated the consequences of local ETP expression in the liver and its effect on hepatic inflammation, fibrosis, and insulin resistance. Accumulation of ETP in the liver induced hepatic inflammation and the development of fibrosis with associated insulin resistance. Surprisingly, ETP overexpression also led to the emergence of liver cancer within 10 months in the SREBP1a transgenic background. Our data revealed that ETP can act as a “second hit” during the progression of NAFLD and can play an important role in the development of NASH and hepatocellular carcinoma (HCC). These observations firmly link elevated levels of ETP to chronic liver disease.Subject terms: Metabolic syndrome, Biological techniques 相似文献
962.
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964.
Making use of the operator product expansion, we derive a general class of sum rules for the imaginary part of the single-particle self-energy of the unitary Fermi gas. The sum rules are analyzed numerically with the help of the maximum entropy method, which allows us to extract the single-particle spectral density as a function of both energy and momentum. These spectral densities contain basic information on the properties of the unitary Fermi gas, such as the dispersion relation and the superfluid pairing gap, for which we obtain reasonable agreement with the available results based on quantum Monte-Carlo simulations. 相似文献
965.
Radical‐Induced Hydrosilylation Reactions for the Functionalization of Two‐Dimensional Hydride Terminated Silicon Nanosheets
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Tobias Helbich Alina Lyuleeva Dr. Ignaz M. D. Höhlein Philipp Marx Lavinia M. Scherf Julian Kehrle Prof. Dr. Thomas F. Fässler Prof. Dr. Paolo Lugli Prof. Dr. Bernhard Rieger 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(18):6194-6198
Herein we present the functionalization of freestanding silicon nanosheets (SiNSs) by radical‐induced hydrosilylation reactions. An efficient hydrosilylation of Si?H terminated SiNSs can be achieved by thermal initiation or the addition of diazonium salts with a variety of alkene or alkyne derivatives. The radical‐induced hydrosilylation is applicable for a wide variety of substrates with different functionalities, improving the stability and dispersibility of the functional SiNSs in organic solvents and potentially opening up new fields of application for these hybrid materials. 相似文献
966.
Heiko Minwegen Malte Döntgen Yann Fenard Philipp Morsch Karl Alexander Heufer 《Proceedings of the Combustion Institute》2021,38(1):749-755
As ketene is a crucial intermediate for the high-temperature combustion of oxygenated hydrocarbons in general, an in-depth understanding of its chemistry is a fundamental requirement for the kinetic modeling of bio-based fuels. To gain a profound insight into the decomposition of ketene and subsequent reaction pathways high level ab initio methods were used. DSD-PBEP86/cc-pVTZ level of theory was applied for the geometries and frequencies, while single-point energies were determined at the CCSDT-1a level of theory extrapolated to the basis set limit. The reaction rate parameters for 38 reactions involved in the ketene chemistry including C1 to C4 species like acetylene, ethylene, propyne and allene were computed. For a total of 16 species, the thermochemistry were updated. The calculated rate parameters and the two new species cyclopropenone and 1,4-dioxo-1,3-butadiene were used to update the AramcoMech 3.0 base mechanism, which was then validated against speciation measurements during ketene pyrolysis. A reaction pathway analysis was performed to find the most prominent reactions at the investigated conditions and to discuss the simulation results. A significant improvement in the model’s prediction capability was found when applying the newly calculated reaction rate parameter and thermochemical data. 相似文献
967.
Mathis Baalmann Laura Neises Sebastian Bitsch Hendrik Schneider Lukas Deweid Philipp Werther Nadja Ilkenhans Martin Wolfring Michael J. Ziegler Jonas Wilhelm Harald Kolmar Richard Wombacher 《Angewandte Chemie (International ed. in English)》2020,59(31):12885-12893
Bioorthogonal chemistry holds great potential to generate difficult‐to‐access protein–protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chemistry, use of undesirable catalysts, or often do not result in quantitative product formation. Here we present a highly efficient technology for protein functionalization with commonly used bioorthogonal motifs for Diels–Alder cycloaddition with inverse electron demand (DAinv). With the aim of precisely generating branched protein chimeras, we systematically assessed the reactivity, stability and side product formation of various bioorthogonal chemistries directly at the protein level. We demonstrate the efficiency and versatility of our conjugation platform using different functional proteins and the therapeutic antibody trastuzumab. This technology enables fast and routine access to tailored and hitherto inaccessible protein chimeras useful for a variety of scientific disciplines. We expect our work to substantially enhance antibody applications such as immunodetection and protein toxin‐based targeted cancer therapies. 相似文献
968.
J. Philipp Wagner 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(53):12119-12124
Peroxy radical hydrogen-shifts are pivotal elementary reaction steps in the oxidation of small hydrocarbons in autoignition and the lower atmosphere. Although these reactions are typically associated with a substantial barrier, we demonstrate that the [1,5]H-shift in the peroxy species derived from the 2-hydroxyphenyl radical 1 is so facile that it even proceeds rapidly in an argon matrix at 35 K through a proton-coupled electron transfer mechanism. Hydrogen-bound complexes of o-benzoquinone are identified as the main reaction products by infrared spectroscopy although their formation through O−O bond scission is hampered by a barrier of 11.9 kcal mol−1 at the ROCCSD(T)/cc-pVTZ/UB3LYP/6–311G(d,p) level of theory. 相似文献
969.
Dr. Philipp Gotico Dr. Dooshaye Moonshiram Dr. Cunming Liu Dr. Xiaoyi Zhang Dr. Régis Guillot Dr. Annamaria Quaranta Dr. Zakaria Halime Dr. Winfried Leibl Prof. Ally Aukauloo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(13):2859-2868
Inspired by the sulfur-rich environment found in active hydrogenase enzymes, a Ni-based proton reduction catalyst with pentadentate N2S3 ligand was synthesised. When coupled with [Ru(bpy)3]2+ (bpy=2,2′-bipyridine) as photosensitiser and ascorbate as electron donor in a 1:1 mixture of dimethylacetamide and aqueous ascorbic acid/ascorbate buffer, the catalyst showed improved photocatalytic activity compared with a homologous counterpart bearing a tetradentate N2S2 ligand. The mechanistic pathway of photoinduced hydrogen evolution was comprehensively analysed through optical transient absorption and time-resolved X-ray absorption spectroscopy, which revealed important electronic and structural changes in the catalytic system during photoirradiation. The NiII catalyst undergoes a photoinduced metal-centred reduction to form a NiI intermediate with distorted square-bipyramidal geometry. Further kinetic analyses revealed differences in charge-separation dynamics between the pentadentate and tetradentate forms. 相似文献
970.
Giovanni Luzi Philipp Epple Cornelia Rauh Antonio Delgado 《Archive of Applied Mechanics (Ingenieur Archiv)》2013,83(11):1607-1636
Micro-structured optical fibres (i.e. fibres that contain holes) have assumed a high profile in recent years and given rise to many novel optical devices. The problem of manufacturing such fibres by heating and then drawing a preform is considered for the case of annular capillaries. A fluid mechanics model suggested in the literature that uses asymptotic analysis based on the small aspect ratio of capillaries has been compared with the full 3D set of the N.–St. equations, for modelling the fabrication of capillaries. The final asymptotic equations, analysed in some asymptotic limits, are solved numerically and then compared with the N.–St. solutions, obtained with a commercial finite elements solver. These asymptotic limits give valuable practical information about the control parameters that influence the drawing process, taking into account the effects of surface tension and inner pressure, since those are of essential importance during drawing. It is shown that the asymptotic method delivers reliable results as long as the inner pressure does not exceed too high values. 相似文献