Configurationally and conformationally homogeneous cyclicN-aryl sulfimides. II.13C-and1H NMR spectra

The configuration and (in case of mobile ring systems) the preferred conformation in a series of thiane- and ofcis-andtrans-1-thiadecalin-1-N-4-chlorophenyl imides were assigned by means of¹³C- and¹H nmr spectroscopy.¹H nmr criteria known to be valid for determination of the stereochemistry of cyclic sulfoxides may be applied (with limitations) to cyclicN-aryl sulfimides, if both isomers (S–N bond equatorial and axial, respectively) are known. The assignments are easier, and unambiguous for single isomers, by comparison of¹³C nmr chemical shifts of ring carbon atoms of sulfimides and sulfides. The influence of equatorially and axially oriented sulfimide groups on the chemical shifts of neighbouring protons, and on the carbon atoms of the heterocyclic rings are discussed in detail.

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Konfigurativ und konformationell einheitliche cyclische N-Aryl-sulfimide. II.¹³C- und¹H-NMR-Spektroskopie

Zusammenfassung Die Konfiguration und (bei beweglichen Ringsystemen) die bevorzugte Konformation einer Reihe von Thian- und voncis- undtrans-1-Thiadekalin-1-N-4-chlorophenylimiden wurde durch¹³C- und¹H-NMR-Spektroskopie bestimmt. Bekannte¹H-NMR-Kriterien zur Festlegung der Stereochemie cyclischer Sulfoxide sind (mit Einschränkungen) auch bei cyclischenN-Arylsulfimiden anwendbar, wenn beide Isomere (S–N-Bindung äquatorial bzw. axial) bekannt sind. Leichter, und auch bei Vorliegen von nur einem Isomeren eindeutig, gelingt die Zuordnung durch Vergleich der¹³C-NMR-Verschiebungen der Ringkohlenstoffatome von Sulfimiden und Sulfiden. Die Einflüsse äquatorial oder axial orientierter Sulfimidgruppen auf die chemischen Verschiebungen benachbarter Wasserstoffe und der Kohlenstoffe des Heterorings werden diskutiert.

     

Molecular dynamics simulation of titanium dioxide nanoparticle sintering

Nanoparticles have been an area of active research in recent years due to their properties, which can be greatly different from the bulk. In this work, we study the sintering of TiO2 nanoparticles using molecular dynamics simulations. Such sintering occurs in flame reactors where nanotitania is prepared via the chloride process. Decrease in free energy due to reduction in surface area is the main driving force for sintering of particles. Simulations, at various starting temperatures and orientations, indicate that the process of sintering is strongly affected by temperature and initial orientation. Extremely high diffusion of ions in the neck region of sintering nanoparticles supports the idea that solid-state diffusion is significant in metal-oxide nanoparticle sintering. It is found that the dipole-dipole interaction between sintering nanoparticles plays a very important role at temperatures away from the melting point. The duration of the simulation is not enough to observe the complete sintering process, but important initial stages are well studied.     

Nachweis von C (15)-epimeren Coleonen C und D in der Natur und ihre Bedeutung für den sterischen Verlauf der Bildung des Spirocyclopropanrings

Natural Occurrence of C(15)-Epimeric Coleons C and D and its Significance to the Stereochemistry of the Formation of a Spirocyclopropanring In a previous paper some evidence was presented for a predominant occurrence of epimeric coleons ((15S)-coleon C ((15 S)- 1a ), and (15S)-coleon D ((15S)- 2a )) in Plectranthus lanuginosus [1], The proposed structures have now been proven by careful comparison of their physical data with those of the already described C(15)-epimers whose structures were deduced by X-ray analysis of a derived cis-diketone 3 [5], Examination of the epimeric purity of coleons possessing a 2-hydroxy-1-methylethyl side-chain (coleons C , D , H , I , I ′ and derivatives) isolated from seven different species (Coleus, Plectranthus and Solenostemon) has shown that these coleons always occur as a mixture of C(15)-epimers, although in most cases with one predominant epimer. The consequences for the stereochemistry of the postulated in vivo formation of the methyl-substituted spirocyclopropane substructure is discussed.     

A correlational inequality for linear extensions of a poset

Suppose 1, 2, and 3 are pairwise incomparable points in a poset onn≥3 points. LetN (ijk) be the number of linear extensions of the poset in whichi precedesj andj precedesk. Define λ by $$\lambda = \frac{{N(213)N(312)}}{{\left[ {N(123) + N(132)} \right]\left[ {N(231) + N(321)} \right]}}$$ Two applications of the Ahlswede-Daykin evaluation theorem for distributive lattices are used to prove that λ?(n?1)²/(n+1)² for oddn, and λ?(n?2)/(n+2) for evenn. Simple examples show that these bounds are best-possible. Shepp (Annals of Probability, 1982) proved thatP(12)?P(12/13), the so-calledxyz inequality, whereP(ij) is the probability thati precedesj in a randomly chosen linear extension of the poset, thus settling a conjecture of I. Rival and B. Sands. The preceding bounds on λ yield a simple proof ofP(12)<P(12/13), which had also been conjectured by Rival and Sands.     

Preparative uv-laser photochemistry of the azoalkane spiro(2,3-diazabicyclo [2.2.1]hept-2-ene-7′,1-cyclopropane): Trapping of the 1,4-Diradical 2-(3-Cyclopentenyl) ethyl by Molecular Oxygen

Photo-extrusion of nitrogen from the azoalkane 1 in the presence of molecular oxygen gave besides the hydrocarbons 3 and 5, the endoperoxide 10 and hydroperoxide 11, the former via trapping of the 1,4-diradical 4 by triplet oxygen, the latter by ene-reaction-6f hydrocarbon 5 with singlet oxygen.     

Equivariant framability of involutions on homotopy spheres

Let G be the group Z₂. Denote byR ^n,k theR ^n+k with non trivial G-action on the first n coordinates. Let ^n,k be the trivial bundle with fibreR ^n,k. We say that a G-manifold M is (n,k)-framable if t(M)= =^n,k in KO_G(M) with t(M) the tangent bundle of M. We show that if G acts on a homotopy sphere ^n+k such that the fixed point set is a k-dimensional homotopy sphere then is (n,k)-framable.     

A critical evaluation of high performance liquid chromatography-electrospray ionisation-mass spectrometry and capillary electrophoresis-electrospray-mass spectrometry for the detection and determination of small molecules of significance in clinical and forensic science

A critical review of applications for the period 2000-2003, taken from the Web of Knowledge database, of the techniques high performance liquid chromatography-electrospray ionisation-mass spectrometry (HPLC-ESI-MS) and capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) to the detection and determination of small molecules of significance in clinical and forensic science is presented. The molecules of mass less than 500 Da are chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions although other ions such as [M-H](-), [M+Na](+) and [M+NH(4)](+) are also reported. The structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, carbohydrates, benzimidazoles, other heterocycles, sulphonylureas, anthracyclines, sulphonamides, penicillins, cephalosporins, tetracyclines, nitrocatechols, steroids, flavonoids, oxazaphosphorines, cannabinols, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole and time-of-flight mass spectrometers. The review then gives a critical evaluation of these recent HPLC-ESI-MS and CE-ESI-MS analytical methods for the detection and determination of small molecules of clinical and forensic significance. Analytical information on, for example, sample concentration techniques, HPLC and CE separation conditions, recoveries from biological media and limits of detection (LODs) are provided.     

Comparing Intrinsic Reactivities of the First‐ and Second‐Generation Ruthenium Metathesis Catalysts in the Gas Phase

An experimental comparison of the gas‐phase reactivity of the 14‐electron reactive intermediates produced by phosphine dissociation from the first‐ and second‐generation ruthenium metathesis catalysts, (L)Cl₂Ru?CHR (L=PCy₃ or NHC), supports Grubbs's contention that the second‐generation catalysts show hundred‐fold higher phenomenological activity despite a slower phosphine dissociation because of a much more‐favorable partitioning of the 14‐electron active species towards product‐forming steps. The gas‐phase study finds, in ring‐opening metathesis of norbornene as well as acyclic metathesis of ethyl vinyl ether, that the first‐generation systems display evidence for a higher barrier above that for phosphine dissociation; the second‐generation systems, on the other hand, behave as if there is no significantly higher barrier.     

Monte Carlo simulations of the solution structure of simple alcohols in water-acetonitrile mixtures

Monte Carlo simulations have been performed to explore the solution structure of ethyl, isopropyl, isobutyl, and tertiary butyl alcohols in pure water, pure acetonitrile, and different mixtures of the two solvents. The explicit solvent studies in NpT ensembles at T = 298 K illustrate that the solute "discriminates" the solvent's components and that the composition of the first solvation shell differs from that of the bulk solution. Since the polarizable continuum dielectric method (PCM) does not presently model the solvation of molecules with both polar and apolar sites in mixed protic solvents, we suggest a direction for further program development wherein a continuum dielectric method would accept more than one solvent and the solute sites would be solvated by user-defined solvent components. The prevailing solvation model will be determined upon the lowest free energy calculated for a particular solvation pattern of the solute having a specific conformational/tautomeric state. Characterization of equilibrium hydrogen-bond formation becomes a complicated problem that depends on the chemical properties of the solute and its conformation, as well as upon the varying nature of the first solvation shell. For example, while the number of hydrogen bonds to secondary and tertiary alcohol solutes are nearly constant in pure water and in water-acetonitrile mixtures with at least 50% water content, the number of hydrogen bonds to primary alcohols gradually decreases for most of their conformations when acetonitrile content is increased. Nonetheless, the calculations indicate that O-H...O(water) hydrogen bonds are still possible in a small fraction of the arrangements for the solution models with water content of 30% or less. The isopentene solute does not form any observable hydrogen bonds, despite having an electron-rich, double-bond site.