Well-posedness for the nonlocal nonlinear Schrödinger equation

We establish local well-posedness for small initial data in the usual Sobolev spaces Hs(R), s?1, and global well-posedness in H¹(R), for the Cauchy problem associated to the nonlocal nonlinear Schrödinger equation

     

Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors

The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat infectious diseases, including viral infections. Herein, the antiviral effects of the lysine linked dimer des-Cys¹¹, Lys¹²,Lys¹³-(pBthTX-I)₂K ((pBthTX-I)₂K)) and derivatives against SARS-CoV-2 are reported. The lead peptide (pBthTX-I)₂K and derivatives showed attractive inhibitory activities against SARS-CoV-2 (EC₅₀ = 28–65 µM) and mostly low cytotoxic effect (CC₅₀ > 100 µM). To shed light on the mechanism of action underlying the peptides’ antiviral activity, the Main Protease (M^pro) and Papain-Like protease (PL^pro) inhibitory activities of the peptides were assessed. The synthetic peptides showed PL^pro inhibition potencies (IC₅₀s = 1.0–3.5 µM) and binding affinities (K_d = 0.9–7 µM) at the low micromolar range but poor inhibitory activity against M^pro (IC₅₀ > 10 µM). The modeled binding mode of a representative peptide of the series indicated that the compound blocked the entry of the PL^pro substrate toward the protease catalytic cleft. Our findings indicated that non-toxic dimeric peptides derived from the Bothropstoxin-I have attractive cellular and enzymatic inhibitory activities, thereby suggesting that they are promising prototypes for the discovery and development of new drugs against SARS-CoV-2 infection.     

The Mixing Time Evolution of Glauber Dynamics for the Mean-Field Ising Model

We consider Glauber dynamics for the Ising model on the complete graph on n vertices, known as the Curie-Weiss model. It is well-known that the mixing-time in the high temperature regime (β < 1) has order n log n, whereas the mixing-time in the case β > 1 is exponential in n. Recently, Levin, Luczak and Peres proved that for any fixed β < 1 there is cutoff at time with a window of order n, whereas the mixing-time at the critical temperature β = 1 is Θ(n ^3/2). It is natural to ask how the mixing-time transitions from Θ(n log n) to Θ(n ^3/2) and finally to exp (Θ(n)). That is, how does the mixing-time behave when β = β(n) is allowed to tend to 1 as n → ∞. In this work, we obtain a complete characterization of the mixing-time of the dynamics as a function of the temperature, as it approaches its critical point β _c  = 1. In particular, we find a scaling window of order around the critical temperature. In the high temperature regime, β = 1 − δ for some 0 < δ < 1 so that δ ² n → ∞ with n, the mixing-time has order (n/δ) log(δ ² n), and exhibits cutoff with constant and window size n/δ. In the critical window, β = 1± δ, where δ ² n is O(1), there is no cutoff, and the mixing-time has order n ^3/2. At low temperature, β = 1 + δ for δ > 0 with δ ² n → ∞ and δ = o(1), there is no cutoff, and the mixing time has order . Research of J. Ding and Y. Peres was supported in part by NSF grant DMS-0605166.     

Strong Spherical Asymptotics for Rotor-Router Aggregation and the Divisible Sandpile

The rotor-router model is a deterministic analogue of random walk. It can be used to define a deterministic growth model analogous to internal DLA. We prove that the asymptotic shape of this model is a Euclidean ball, in a sense which is stronger than our earlier work (Levine and Peres, Indiana Univ Math J 57(1):431–450, 2008). For the shape consisting of sites, where ω _d is the volume of the unit ball in , we show that the inradius of the set of occupied sites is at least r − O(logr), while the outradius is at most r + O(r ^α ) for any α > 1 − 1/d. For a related model, the divisible sandpile, we show that the domain of occupied sites is a Euclidean ball with error in the radius a constant independent of the total mass. For the classical abelian sandpile model in two dimensions, with n = πr ² particles, we show that the inradius is at least , and the outradius is at most . This improves on bounds of Le Borgne and Rossin. Similar bounds apply in higher dimensions, improving on bounds of Fey and Redig. Yuval Peres is partially supported by NSF grant DMS-0605166.     

Mixing Time of Critical Ising Model on Trees is Polynomial in the Height

In the heat-bath Glauber dynamics for the Ising model on the lattice, physicists believe that the spectral gap of the continuous-time chain exhibits the following behavior. For some critical inverse-temperature β _c , the inverse-gap is O(1) for β < β _c , polynomial in the surface area for β = β _c and exponential in it for β > β _c . This has been proved for \mathbbZ²{\mathbb{Z}^2} except at criticality. So far, the only underlying geometry where the critical behavior has been confirmed is the complete graph. Recently, the dynamics for the Ising model on a regular tree, also known as the Bethe lattice, has been intensively studied. The facts that the inverse-gap is bounded for β < β _c and exponential for β > β _c were established, where β _c is the critical spin-glass parameter, and the tree-height h plays the role of the surface area. In this work, we complete the picture for the inverse-gap of the Ising model on the b-ary tree, by showing that it is indeed polynomial in h at criticality. The degree of our polynomial bound does not depend on b, and furthermore, this result holds under any boundary condition. We also obtain analogous bounds for the mixing-time of the chain. In addition, we study the near critical behavior, and show that for β > β _c , the inverse-gap and mixing-time are both exp[Θ((β − β _c )h)].     

On Coulomb drag in double layer systems

We argue, for a wide class of systems including graphene, that in the low temperature, high density, large separation and strong screening limits the drag resistivity behaves as d(-4), where d is the separation between the two layers. The results are independent of the energy dispersion relation, the dependence on momentum of the transport time, and the electronic wave function structure. We discuss how a correct treatment of the electron-electron interactions in an inhomogeneous dielectric background changes the theoretical analysis of the experimental drag results of Kim et?al (2011 Phys. Rev. B 83 161401). We find that a quantitative understanding of the available experimental data (Kim et?al 2011 Phys. Rev. B 83 161401) for drag in graphene is lacking.     

Convolutions of cantor measures without resonance

Denote by µ _a the distribution of the random sum \((1 - a)\sum\nolimits_{j = 0}^\infty {{w_j}{a^j}} \), where P(ω _j = 0) = P(ω _j = 1) = 1/2 and all the choices are independent. For 0 < a < 1/2, the measure µ _a is supported on C _a , the central Cantor set obtained by starting with the closed united interval, removing an open central interval of length (1 ? 2a), and iterating this process inductively on each of the remaining intervals. We investigate the convolutions µ _a * (µ _b ° S _λ ^?1 ), where S _λ (x) = λx is a rescaling map. We prove that if the ratio log b/ log a is irrational and λ ≠ 0, then

$D({\mu _a} * ({\mu _b} \circ S_\lambda ^{ - 1})) = \min ({\dim _H}({C_a}) + {\dim _H}({C_b}),1)$

, where D denotes any of correlation, Hausdorff or packing dimension of a measure.

We also show that, perhaps surprisingly, for uncountably many values of λ the convolution µ_1/4* (µ_1/3 ° S _λ ^?1 ) is a singular measure, although dim _H (C _1/4) + dim _H (C _1/3) > 1 and log(1/3)/ log(1/4) is irrational.     

A dimension gap for continued fractions with independent digits

Kinney and Pitcher (1966) determined the dimension of measures on [0, 1] which make the digits in the continued fraction expansion i.i.d. variables. From their formula it is not clear that these dimensions are less than 1, but this follows from the thermodynamic formalism for the Gauss map developed by Walters (1978). We prove that, in fact, these dimensions are bounded by 1−10⁻⁷. More generally, we considerf-expansions with a corresponding absolutely continuous measureμ under which the digits form a stationary process. Denote byE _δ the set of reals where the asymptotic frequency of some digit in thef-expansion differs by at leastδ from the frequency prescribed byμ. ThenE _δ has Hausdorff dimension less than 1 for anyδ>0.     

The classic paradoxes of quantum theory

This paper contains four new dialogues among Simplicio, Salviati, and Sagredo, on the fate of Schrödinger's cat, the existence of physical quantities, the paradigm of Einstein, Podolsky, and Rosen, and why a watched kettle may boil, after all.Dedicated to Nathan Rosen, teacher and friend, on the occasion of his 75th birthday.     

The number of infinite clusters in dynamical percolation

Summary. Dynamical percolation is a Markov process on the space of subgraphs of a given graph, that has the usual percolation measure as its stationary distribution. In previous work with O. H?ggstr?m, we found conditions for existence of infinite clusters at exceptional times. Here we show that for ℤ ^d , with p>p _c , a.s. simultaneously for all times there is a unique infinite cluster, and the density of this cluster is θ(p). For dynamical percolation on a general tree Γ, we show that for p>p _c , a.s. there are infinitely many infinite clusters at all times. At the critical value p=p _c , the number of infinite clusters may vary, and exhibits surprisingly rich behaviour. For spherically symmetric trees, we find the Hausdorff dimension of the set T ^k of times where the number of infinite clusters is k, and obtain sharp capacity criteria for a given time set to intersect T ^k . The proof of this capacity criterion is based on a new kernel truncation technique. Received: 5 May 1997 / In revised form: 24 November 1997