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971.
H. S. Peiser P. De Bièvre P. R. Goodman H. H. Ku 《Accreditation and quality assurance》1996,1(2):67-70
Under favorable conditions, a retrospective test for reliability of published sets of physical property data becomes possible.
The test and the necessary conditions for its use are discussed. The test is applied, by example, to well-documented, periodically
republished nuclidic (atomic) masses of nine low atomic number nuclides. An index of reliability is suggested and evaluated
for the example.
Revised: 27 November 1995 相似文献
972.
K. Raptis K. Mayer F. Hendrickx P. De Bièvre 《Fresenius' Journal of Analytical Chemistry》1998,361(5):400-403
Preparation of two Isotopic Reference Materials of thorium has been performed, starting from highly enriched 232Th (99.99%) and 230Th (99.8%). After full characterization (chemical and isotopic) of these purified base materials the thorium nitrate was transformed
to thorium dioxide. Accurately weighed amounts of the two isotopes in the dioxide form were subsequently dissolved in nitric
acid and resulted in solutions with amount ratios n(230Th)/n(232Th) close to 10–5 (IRMM-035) and 3 · 10–6 (IRMM-036). These gravimetrically prepared ratios were finally verified by means of Thermal Ionization Mass Spectrometry
(TIMS). The purpose of the Reference Materials is to calibrate thorium isotope amount ratio measurements.
Received: 7 July 1997 / Revised: 1 December 1997 / Accepted: 7 December 1997 相似文献
973.
974.
975.
J. Bičák 《Czechoslovak Journal of Physics》1966,16(2):95-98
The variables of a vector meson field are determined within the framework of the Kibble theory as the functions of the metric tensor, affine connection and their derivatives and a system of differential equations is found for the metric tensor and affine connection which is equivalent to the equations of motion of gravitational and vector meson fields. 相似文献
976.
Jifeng Liu Feiyan Liu Nenling Zhang Yafeng Wang Lijia Yang Yuefeng Bi 《Natural product research》2016,30(3):322-326
Two new seco-prezizaane-type sesquiterpenes, 3,4-dehydroneomajucin (1) and 1,2,3,4-tetradehydroneomajucin (2), were isolated from the fruits of Illicium jiadifengpi. The structure of these compounds was determined using 1D and 2D NMR and ESI-MS. The isolates were evaluated for their anti-hepatitis B virus activities on the Hep G2.2.15 cell line. The inhibitory rates of compounds 1 and 2 on the HBeAg and HBsAg expression were 30.08 ± 3.09% and 11.43 ± 1.92% at a concentrations of 68.00 μM and 7.88 ± 1.21% and 16.96 ± 4.24% at a concentration of 68.50 μM, respectively. 相似文献
977.
Christophe Narth Louis Lagardère Étienne Polack Nohad Gresh Qiantao Wang David R. Bell Joshua A. Rackers Jay W. Ponder Pengyu Y. Ren Jean‐Philip Piquemal 《Journal of computational chemistry》2016,37(5):494-506
We propose a general coupling of the Smooth Particle Mesh Ewald SPME approach for distributed multipoles to a short‐range charge penetration correction modifying the charge‐charge, charge‐dipole and charge‐quadrupole energies. Such an approach significantly improves electrostatics when compared to ab initio values and has been calibrated on Symmetry‐Adapted Perturbation Theory reference data. Various neutral molecular dimers have been tested and results on the complexes of mono‐ and divalent cations with a water ligand are also provided. Transferability of the correction is adressed in the context of the implementation of the AMOEBA and SIBFA polarizable force fields in the TINKER‐HP software. As the choices of the multipolar distribution are discussed, conclusions are drawn for the future penetration‐corrected polarizable force fields highlighting the mandatory need of non‐spurious procedures for the obtention of well balanced and physically meaningful distributed moments. Finally, scalability and parallelism of the short‐range corrected SPME approach are addressed, demonstrating that the damping function is computationally affordable and accurate for molecular dynamics simulations of complex bio‐ or bioinorganic systems in periodic boundary conditions. © 2016 Wiley Periodicals, Inc. 相似文献
978.
Identification and determination of the major constituents in Kai‐Xin‐San by UPLC‐Q/TOF MS and UFLC‐MS/MS method 下载免费PDF全文
Chunxiao Lv Bosai He Zhenyu Sui Qing Li Kaishun Bi 《Journal of mass spectrometry : JMS》2016,51(7):479-490
In order to have overall chemical material information of Kai‐Xin‐San (KXS), the reliable ultra‐high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometer (UHPLC–Q‐TOF‐MS) and ultra‐fast liquid chromatography mass spectrometer (UFLC‐MS/MS) methods were developed for the identification and determination of the major constituents in KXS. Moreover, the UHPLC–Q‐TOF‐MS method was also applied to screen for multiple absorbed components in rat plasma after oral administration of KXS. The UHPLC–Q‐TOF‐MS method was achieved on Agilent 6520 Q‐TOF mass and operated in the negative ion mode. Good separation was performed on a ZORBAX Eclipse Plus C18 column with a gradient elution at a flow rate of 0.2 ml/min. A total of 92 compounds in KXS were identified or tentatively characterized based on their exact molecular weights, fragmentation patterns, and literature data. A total of 26 compounds including 23 prototype components and three metabolites were identified in rat plasma after oral administration of KXS. Then, 16 major bioactive constituents were chosen as the benchmark substances to evaluate the quality of KXS. Their quantitative analyses were performed by a triple quadrupole tandem mass spectrometer (MS/MS) operating in multiple‐reaction monitoring mode(MRM). The analysis was completed with a gradient elution at a flow rate of 0.4 ml/min within 35 min. The simple and fast method was validated and showed good linearity, precision, and recovery. Furthermore, the method was successful applied for the determination of 16 compounds in KXS. All results would provide essential data for identification and quality control of active chemical constituents in KXS. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
979.
A simple HPLC method was developed for determination of quercitrin and isoquercitrin in rat plasma. Reversed-phase HPLC was employed for the quantitative analysis using kaempferol-3-O-beta-D-glucopyranoside-7-O-alpha-L-rhamnoside as an internal standard. Following extraction from the plasma samples with ethyl acetate-isopropanol (95:5, v/v), these two compounds were successfully separated on a Luna C(18) column (250 x 4.6 mm, 5 microm) with isocratic elution of acetonitrile-0.5% aqueous acetic acid (17:83, v/v) as the mobile phase. The flow-rate was set at 1 mL/min and the eluent was detected at 350 nm for both quercitrin and isoquercitrin. The method was linear over the studied ranges of 50-6000 and 50-5000 ng/mL for quercitrin and isoquercitrin, respectively. The intra- and inter-day precisions of the analysis were better than 13.1 and 13.2%, respectively. The lower limits of quantitation for quercitrin and isoquercitrin in plasma were both of 50 ng/mL. The mean extraction recoveries were 73 and 61% for quercitrin and isoquercitrin, respectively. The validated method was successfully applied to pharmacokinetic studies of the two analytes in rat plasma after the oral administration of Hypericum japonicum thunb. ethanol extract. 相似文献
980.
Controlling orientations of immobilized oligopeptides using N-terminal cysteine labels 总被引:1,自引:0,他引:1
This letter reports a strategy of using N-terminal cysteine labels for controlling the immobilization of oligopeptides on aldehyde-terminated surfaces through the formation of stable thiazolidine rings. We also study the effect of cysteine position (either N-terminal or C-terminal) and lysine residue on the immobilization of oligopeptides. On the basis of our ellipsometry and quartz crystal microbalance (QCM) results, we conclude that the proposed immobilization strategy is highly site-specific. It works only when cysteine is in the N-terminal position, and the formation of thiazolidine is much faster than the formation of imines between lysine residues and aldehydes, even in the presence of a reducing agent such as NaBH(3)CN. By labeling an oligopeptide CSNKTRIDEANNKATKML with an N-terminal cysteine, we immobilize this oligopeptide on an aldehyde-terminated surface and investigate the enzymatic activity of trypsin acting on the oligopeptide. It is found that trypsin is able to cleave the immobilized oligopeptide having a single anchoring point at the N-terminal cysteine. No cleavage is observed when the oligopeptide is immobilized through multiple anchoring points at lysine residues. 相似文献