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Journal of Visualization - Interpreting the decision-making of black boxes in machine learning becomes urgent nowadays due to their lack of transparency. One effective way to interpret these models... 相似文献
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Wang Peiwen Hu Eming Wang Qingliang Lei Zhiwu Wang Hongqiang Zhang Yan Hou Wei Zhang Rui 《Journal of Radioanalytical and Nuclear Chemistry》2019,322(2):597-604
Journal of Radioanalytical and Nuclear Chemistry - Both uranium and beryllium are very important strategic metals and have been applied to many fields, such as nuclear industries, atomic energy,... 相似文献
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Yanhong Chao Wenshuai Zhu Jiaxin Chen Peiwen Wu Huaming Li 《Green Chemistry Letters and Reviews》2014,7(4):330-336
Graphene-like layered hexagonal boron nitride (g-BN) was prepared and characterized. The performance of using g-BN as an adsorbent for removal of fluoroquinolone antibiotic gatifloxacin (GTF) from aqueous solution was evaluated. g-BN showed an excellent adsorption capability with notable GTF adsorption ratio of more than 90%. Data of equilibrium adsorption of GTF onto g-BN at different temperatures were represented by Langmuir, Freundlich and Tempkin isotherm models, and Langmuir exhibited the best fitting with the maximum adsorption capacity of 88.5 mg·g?1 at 288 K. GTF adsorption was insignificantly affected by solution pH. Competitive role of Na+ and Ca2+ in the solution inhibited the adsorption of GTF and decreased the adsorption capacity a bit. The adsorption process was spontaneous and exothermic. The adsorption was probably governed by π–π interaction between GTF and g-BN, and electrostatic interaction may also exist in the adsorption process. 相似文献
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微波促进酸性离子液体催化水杨酸酯化 总被引:2,自引:0,他引:2
用自制的硫酸氢1-甲基-3-(3-磺酸基丙基)咪唑([MIMPS]HSO4)酸性离子液体作为水杨酸与醇的酯化反应催化剂,考察了温度、时间、物料配比和离子液体用量等因素对酯化反应的影响,优化的最佳反应条件为: 微波辐射时间20 min,反应温度95 ℃,醇与酸摩尔比3∶1(水杨酸的量为0.02 mol),[MIMPS]HSO4用量10 mmol,水杨酸甲酯的产率和选择性分别为91.9%和99.0%。 离子液体回收循环使用4次,催化效率不变。 与热催化酯化反应相比,微波辐射可缩短反应时间;水杨酸与不同碳链醇的酯化产率随着碳链的增加而降低,同碳链的伯醇酯化率比仲醇高。 相似文献
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Yiran Li Fan Huo Liusheng Chen Haiqi Wang Jianzhuang Wu Peiwen Zhang Nan Feng Wei Li Lan Wang Yichun Wang Prof. Dr. Xiaojian Wang Prof. Dr. Xiaoliang Yang Prof. Dr. Zhiqiang Lu Prof. Dr. Yang Mao Prof. Dr. Chao Yan Prof. Dr. Lin Ding Prof. Dr. Huangxian Ju 《Angewandte Chemie (International ed. in English)》2023,62(26):e202218148
The frequent mutation of KRAS oncogene in some of the most lethal human cancers has spurred incredible efforts to develop KRAS inhibitors, yet only one covalent inhibitor for the KRASG12C mutant has been approved to date. New venues to interfere with KRAS signaling are desperately needed. Here, we report a “localized oxidation-coupling” strategy to achieve protein-specific glycan editing on living cells for disrupting KRAS signaling. This glycan remodeling method exhibits excellent protein and sugar specificity and is applicable to different donor sugars and cell types. Attachment of mannotriose to the terminal galactose/N-acetyl-D-galactosamine epitopes of integrin αvβ3, a membrane receptor upstream of KRAS, blocks its binding to galectin-3, suppresses the activation of KRAS and downstream effectors, and mitigates KRAS-driven malignant phenotypes. Our work represents the first successful attempt to interfere with KRAS activity by manipulating membrane receptor glycosylation. 相似文献
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Xiaowei Jiang De'An Xiong Yingli An Peiwen Zheng Wangqing Zhang Linqi Shi 《Journal of polymer science. Part A, Polymer chemistry》2007,45(13):2812-2819
The synthesis of a thermoresponsive hydrogel of poly(glycidyl methacrylate‐co‐N‐isopropylacrylamide) (PGMA‐co‐PNIPAM) and its application as a nanoreactor of gold nanoparticles are studied. The thermoresponsive copolymer of PGMA‐co‐PNIPAM is first synthesized by the copolymerization of glycidyl methacrylate and N‐isopropylacrylamide using 2,2′‐azobis(isobutyronitrile) as an initiator in tetrahydrofuran at 70 °C and then crosslinked with diethylenetriamine to form a thermoresponsive hydrogel. The lower critical solution temperature (LCST) of the thermoresponsive hydrogel is about 50 °C. The hydrogel exists as 280‐nm spheres below the LCST. The diameter of the spherical hydrogel gradually decreases to a minimum constant of 113 nm when the temperature increases to 75 °C. The hydrogel can act as a nanoreactor of gold nanoparticles because of the coordination of nitrogen atoms of the crosslinker with gold ions, on which a hydrogel/gold nanocomposite is synthesized. The LCST of the resultant hydrogel/gold nanocomposite is similar to that of the hydrogel. The size of the resultant gold nanoparticles is about 15 nm. The hydrogel/gold nanocomposite can act as a smart and recyclable catalyst. At a temperature below the LCST, the thermoresponsive nanocomposite is a homogeneous and efficient catalyst, whereas at a temperature above the LCST, it becomes a heterogeneous one, and its catalytic activity greatly decreases. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 2812–2819, 2007 相似文献
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基于目前研究最广泛的刚性折纸(Tachi-origami)样式,通过改变其初始折叠角度构建出4种不同的蜂窝胞元,并且通过排列分布将其组成夹芯梁。采用商用有限元软件Abaqus/explicit对准静态和爆炸载荷作用下可折叠芯层夹芯梁的力学响应进行研究,分析可折叠芯层的泊松比变化规律、夹芯梁背板挠度以及能量吸收机理;并将夹芯梁与等质量的实体梁进行对比。采用后面板最大挠度作为抗爆性能的评价,结果发现:可折叠芯层在准静态载荷下具有一定的负泊松比效应;夹芯梁的抗爆性能优于实体梁,曲边蜂窝的初始折角对其作为芯层夹芯梁的抗爆性能有较大影响,随着初始折角的逐渐增大,其抗爆性能逐渐下降;当初始折角为直角时对应于方孔直边蜂窝,其抗爆性能最差。 相似文献
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R134a水平管内流动凝结换热的实验研究 总被引:3,自引:0,他引:3
1引言为了保护地球大气环境,在制冷、空调及热泵中应用对大气臭氧层无破坏作用的新型工质是全球性的紧迫任务。目前,比较一致地认为,R134a是最有可能替代R12的新型工质。但是关于R134a的传热性能的研究还不够充分,尤其是对凝结换热,一些现有的关联式还不能很有把握地推广应用于R134a,还必须进行大量的研究工作,以查明R134a的传热特性。Eckels于1991年曾测量了蒸汽干度从0.8到0.l的范围内R134a在水平管内的平均凝结换热系数山。结果表明,R134a的平均凝结换热系数比R12的高约25~35%;并且指出,Shah、Thaviss、Cavallini三个… 相似文献