Sub-Stonean spaces and corona sets

A self-contained account of the theory of sub-Stonean spaces, and their relations to Stonean spaces and Rickart spaces is given. Of particular interest are the corona sets (of the form β(X) for locally compact, σ-compact spaces, because these highly nontrivial sub-Stonean spaces lend themselves to C?ech-cohomological considerations. The theory of sub-Stonean spaces is essential for our solution of the diagonalization problem for C(X)? M_n, found in K. Grove and G. K. Pedersen, Diagonalizing matrices over C(X), submitted for publication.     

Electron capture by tetra- and di-chlorobenzene molecules. Comparative studies by position annihilation and ODESR methods

Experiments on inhibition and anti-inhibition of Ps formation and also on optical detection of ESR spectra in squalene solutions with 1,2,4,5-C₆H₂Cl₄ and p-C₆H₄Cl₂ have demonstrated the presence of short-lived molecular radical-anions (products of the spur electron capture by additives), their lifetimes being longer than roughly 10 ps and shorter than 10–30 ns. The cross section of electron capture by p-C₆H₄Cl₂ in squalane is nearly one-tenth of that by 1,2,4,5-C₆H₂Cl₄ and CCl₄ at concentration ? 0.02 M, while 10% of the electrons cannot be trapped even at 0.25 M p-C₆H₄Cl₂. Probably the electrons in the high-electric-field (0.3–3 MV/cm) regions of the spurs cannot be effectively captured by p-C₆H₄Cl₂, which is a shallow electron trap. Similar effects of the high electric fields of the charged spur series seem to influence the Ps formation appreciably, along with the other effects discussed in previous papers. Several new results can be predicted, by use of this interpretation. Both methods employed are emphasized to be selective with respect to geminate spur particles.     

New synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides.

The 3'-iodonucleoside 4 and the 3'-O-methylsulfonylthymidine 9 have been synthesized by condensation of silylated uracils 2 with methyl 5-O-tert-butyldiphensilyl-2,3-dideoxy-3-iodo-D-threo-pentofuran oside (3) and methyl 5-O-tert-butyldiphenylsilyl-2-deoxy-3-methylsulfonyl-D-erythro- pentofuranoside (8), respectively. The nucleoside 4 and 9 produced the corresponding 2',3'-didehydro-2',3'-dideoxynucleosides 5 in an elimination reaction on treatment with sodium methoxide. The compounds 5b showed no antiviral activity against HIV-1.     

Synthesis of 1-(3-alkyl-2,3-dideoxy-D-pentofuranosyl)uracils with potential anti-HIV activity.

1-(3-Alkyl-2,3-dideoxy-alpha,beta-D-erythro-pentofuranosyl)uracils and 1-(3-alkyl-2,3-dideoxy-alpha,beta-D-threo-pentofuranosyl)uracils have been prepared from (E)-4,5-di-O-acetyl-2,3-dideoxy-aldehydo-D-glycero-pent-2-enose by a Michael addition reaction of the appropriate organocopper reagent followed in subsequent order by glycosidation of the resulting 3-alkyl-4,5-diacetoxypentanal with methanolic hydrogen chloride, protection with p-methoxybenzoyl chloride, and trimethylsilyl triflate catalyzed coupling with 2,4-di-O-(trimethylsilyl)uracil. The nucleosides were deprotected by treatment with 33% methylamine in absolute ethanol and separated by reversed-phase HPLC.     

Isotopic study of the mechanism of ozone formation

The mechanism of ozone formation has been studied using ¹⁶O and ¹⁸O₂. High-resolution microwave spectroscopy was used to measure the amounts of the isotopomeric ozone species formed. The study is hampered by the very rapid exchange process between the reactants, that tends to scramble the isotopes and hence give a 2:1 statistical ratio between the two possible isotopomers. We have found a strategy to come around this difficulty and conclude that the mechanism is a simple end-on-addition.