Study on the interaction between promethazine hydrochloride and bovine serum albumin by fluorescence spectroscopy

The interaction between promethazine hydrochloride (PMT) and bovine serum albumin (BSA) in vitro was investigated by means of fluorescence spectroscopy and absorption spectroscopy. The fluorescence of BSA was quenched remarkably by PMT and the quenching mechanism was considered as static quenching by forming a complex. The association constants K_a and the number of binding sites n were calculated at different temperatures. The BSA-PMT binding distance was determined to be less than 8 nm, suggesting that energy transfer from BSA to PMT may occur. The thermodynamic parameters of the interaction between PMT and BSA were measured according to the van’t Hoff equation. The enthalpy change (ΔH) and entropy change (ΔS) were calculated to be −23.62 kJ mol⁻¹ and −0.10 J mol⁻¹ K⁻¹, respectively, which indicated that the interaction of PMT with BSA was driven mainly by van der Waals forces and hydrogen bonds. The binding process was a spontaneous process in which Gibbs free energy change (ΔG) was negative. In addition, the results of synchronous fluorescence spectra and three-dimensional fluorescence spectra showed that binding of PMT with BSA can induce conformational changes in BSA.     

Effects of Magnesium Hydroxide on the Flame Retardancy of Ethylene-Vinyl Acetate Copolymers/Nitrile Rubber Blends

The fire-resistant noncorrosive ethylene-vinyl acetate copolymers with vinyl acetate (VA) content > 40 wt.% (EVM)/acrylonitrile-butadiene rubber (NBR)/magnesium hydroxide (MDH) composites were prepared, and the influence of MDH contents on flame retardancy, thermal stability, filler dispersion, and mechanical properties were studied. The flame-retardant effect of three different flame retardants [micro-sized MDH (mMDH), nano-sized MDH (nMDH), and micro-sized aluminum hydroxide (mATH)] was also investigated by cone calorimetry, thermal gravimetric analysis, and rubber process analysis in this paper. The decrease of the heat release rate and total heat release, the increase of residual mass, and the enhancement of thermal stability of the composites were all due to the flame-retardant effect of the MDH. The EVM/NBR vulcanizates had the best flame retardancy when the mMDH content was 180 phr. It was also found that the nMDH, mMDH, and mATH at the same loading had no obvious influence on the limiting oxygen index, while the combustion behaviors measured by the cone calorimeter had significant differences. The addition of ATH prolonged the time to ignition. The mMDH showed a better flame retardancy for EVM/NBR vulcanizates than the nMDH.     

Nonlinear spectral-like schemes for hybrid schemes

In spectral-like resolution-WENO hybrid schemes,if the switch function takes more grid points as discontinuity points,the WENO scheme is often turned on,and the numerical solutions may be too dissipative.Conversely,if the switch function takes less grid points as discontinuity points,the hybrid schemes usually are found to produce oscillatory solutions or just to be unstable.Even if the switch function takes less grid points as discontinuity points,the final hybrid scheme is inclined to be more stable,provided the spectral-like resolution scheme in the hybrid scheme has moderate shock-capturing capability.Following this idea,we propose nonlinear spectral-like schemes named weighted group velocity control(WGVC)schemes.These schemes show not only high-resolution for short waves but also moderate shock capturing capability.Then a new class of hybrid schemes is designed in which the WGVC scheme is used in smooth regions and the WENO scheme is used to capture discontinuities.These hybrid schemes show good resolution for small-scales structures and fine shock-capturing capabilities while the switch function takes less grid points as discontinuity points.The seven-order WGVC-WENO scheme has also been applied successfully to the direct numerical simulation of oblique shock wave-turbulent boundary layer interaction.     

Large Time Asymptotics for the Kadomtsev–Petviashvili Equation

We study the large time asymptotic behavior of solutions to the Kadomtsev–Petviashvili equations $$\left\{\begin{array}{ll} u_{t} + u_{xxx} + \sigma \partial_{x}^{-1}u_{yy} = -\partial_{x}u^{2}, \quad \quad (x, y) \in {\bf R}^{2}, t \in {\bf R},\\ u(0, x, y) = u_{0}( x, y), \, \quad \quad \qquad \qquad (x, y) \in {\bf R}^{2},\end{array}\right.$$ where σ = ±1 and \({\partial_{x}^{-1} = \int_{-\infty}^{x}dx^{\prime} }\) . We prove that the large time asymptotics of the derivative u _x of the solution has a quasilinear character.     

Threshold effects on renormalization group running of neutrino parameters in the low-scale seesaw model

We show that, in the low-scale type-I seesaw model, renormalization group running of neutrino parameters may lead to significant modifications of the leptonic mixing angles in view of so-called seesaw threshold effects. Especially, we derive analytical formulas for radiative corrections to neutrino parameters in crossing the different seesaw thresholds, and show that there may exist enhancement factors efficiently boosting the renormalization group running of the leptonic mixing angles. We find that, as a result of the seesaw threshold corrections to the leptonic mixing angles, various flavor symmetric mixing patterns (e.g., bi-maximal and tri-bimaximal mixing patterns) can be easily accommodated at relatively low energy scales, which is well within the reach of running and forthcoming experiments (e.g., the LHC).     

Magnetization-induced second harmonic generation in a polar ferromagnet

Second harmonic generation (SHG) induced by spontaneous magnetization has been investigated for a polar ferromagnetic crystal of GaFeO3. The Kerr rotation of the second harmonic light becomes gigantic with decreasing temperature below the magnetic transition temperature (approximately =205 K), e.g., as large as 73 degrees at 100 K. The magnetic domains can be visualized by using that large nonlinear Kerr rotation. The spectrum of the magnetization-induced SHG as measured indicates the two-photon resonant electronic process on a Fe3+ ion in the crystal.     

Band-rejection filter based on a Bragg fiber with a defect layer

<正>A novel band-rejection filter based on a Bragg fiber with a defect layer is proposed.A defect layer is introduced in the periodic high/low index layers in the cladding of the Bragg fiber,which results in large confinement loss for some resonant wavelengths inside the band gap range of the Bragg fiber.A segment of the Bragg fiber with a defect layer can be used as a band-rejection filter,whose characteristics are mainly determined by the structure of the Bragg fiber.The simulation results show that the bandwidth of such a band-rejection filter is dependent on the number of the periodic high/low index layers in both sides of the defect layer in the cladding of the Bragg fiber.     

The isotopes259106,260106, and261106

In irradiations of²⁰⁷Pb and²⁰⁸Pb, respectively, with⁵⁴Cr theα-decay of the isotopes²⁵⁹106,²⁶⁰106, and²⁶¹106 could be observed for the first time. For²⁶⁰106 a spontaneous fission branch of (50 _?20 ⁺³⁰ )% was observed. The isotopes were identified by genetic relationships of α-decay after separation in-flight with the velocity filter SHIP and implantation into a position-sensitive silicon surface-barrier detector. The measured partial fission halflife of the doubly even isotope²⁶⁰106 of (7.2 _?2.7 ^+4.8 )ms exceeds the predicted values by at least a factor of 40. This result could be explained by the high shell corrections of the ground state mass, derived from the measured α-decay energies. The experimental results show evidence for an island of purely shell stabilized nuclei in the region of deformed isotopes beyond the actinides.     

On <Emphasis Type="Italic">L</Emphasis><Superscript><Emphasis Type="Italic">1</Emphasis></Superscript>-summability and asymptotic profiles for smooth solutions to Navier–Stokes equations in a 3D exterior domain

The exterior nonstationary problem is studied for the 3D Navier-Stokes equations. The L ¹ -summability is proved for smooth solutions which correspond to initial data satisfying certain symmetry and moment conditions. The result is then applied to show that such solutions decay in time more rapidly than observed in general. Furthermore, an asymptotic expansion is deduced and a lower bound estimate is given for the rates of decay in time. Mathematics Subject Classifications (1991): 35Q30, 76D05.On leave of absence from Institute of Applied Mathematics, Academy of Mathematics and System Sciences. Academia Sinica, Beijing 100080, Peoples Republic of China. Supported by JSPS     

The Dual Properties of Lk-UR and k-SS Space

In this paper, we get some properties in the dual space of Lk-UR and k-SS Banach space.AMS Subject Classification: 46B09