全文获取类型
收费全文 | 2169篇 |
免费 | 69篇 |
国内免费 | 6篇 |
专业分类
化学 | 1558篇 |
晶体学 | 112篇 |
力学 | 55篇 |
数学 | 92篇 |
物理学 | 427篇 |
出版年
2023年 | 16篇 |
2022年 | 49篇 |
2021年 | 40篇 |
2020年 | 38篇 |
2019年 | 46篇 |
2018年 | 35篇 |
2017年 | 59篇 |
2016年 | 84篇 |
2015年 | 42篇 |
2014年 | 58篇 |
2013年 | 197篇 |
2012年 | 111篇 |
2011年 | 135篇 |
2010年 | 88篇 |
2009年 | 73篇 |
2008年 | 117篇 |
2007年 | 96篇 |
2006年 | 96篇 |
2005年 | 73篇 |
2004年 | 59篇 |
2003年 | 50篇 |
2002年 | 52篇 |
2001年 | 28篇 |
2000年 | 32篇 |
1999年 | 25篇 |
1998年 | 14篇 |
1997年 | 15篇 |
1996年 | 19篇 |
1995年 | 21篇 |
1994年 | 24篇 |
1993年 | 22篇 |
1992年 | 24篇 |
1991年 | 24篇 |
1990年 | 15篇 |
1989年 | 17篇 |
1988年 | 15篇 |
1987年 | 19篇 |
1986年 | 23篇 |
1985年 | 17篇 |
1984年 | 27篇 |
1983年 | 21篇 |
1982年 | 28篇 |
1981年 | 30篇 |
1980年 | 22篇 |
1979年 | 23篇 |
1978年 | 20篇 |
1977年 | 11篇 |
1976年 | 13篇 |
1975年 | 18篇 |
1973年 | 16篇 |
排序方式: 共有2244条查询结果,搜索用时 31 毫秒
111.
112.
Domain-based local pair natural orbital methods within the correlation consistent composite approach
Ab initio composite approaches have been utilized to model and predict main group thermochemistry within 1 kcal mol−1, on average, from well-established reliable experiments, primarily for molecules with less than 30 atoms. For molecules of increasing size and complexity, such as biomolecular complexes, composite methodologies have been limited in their application. Therefore, the domain-based local pair natural orbital (DLPNO) methods have been implemented within the correlation consistent composite approach (ccCA) framework, namely DLPNO-ccCA, to reduce the computational cost (disk space, CPU (central processing unit) time, memory) and predict energetic properties such as enthalpies of formation, noncovalent interactions, and conformation energies for organic biomolecular complexes including one of the largest molecules examined via composite strategies, within 1 kcal mol−1, after calibration with 119 molecules and a set of linear alkanes. © 2019 Wiley Periodicals, Inc. 相似文献
113.
114.
One of the key steps in the synthesis of ABT-431 is the diastereoselective cyclization of thieny alcohol 1 to trans amide 2. We report a detailed study of the influence of acids, solvents and temperature over the ratio of cis and trans diastereomers. 相似文献
115.
The synthesis of a benzooxazol-5-yl acetic acid derivative (9) with strong heparanase and angiogenesis inhibitory activity, and thus possible commercial interest, is described in detail. 相似文献
116.
117.
Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole
A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde la-1,malononitrile 2 and 4-hydroxy-6-methylpyrone 3.All the synthesized compounds were screened against six bacterial pathogens,namely B.subtilis,C.tetani,S.pneumoniae,S.typhi,V.cholerae, E.coli and antifungal activity against,two fungal pathogens,A.fumigatus and C.albicans using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs,against most of employed strains. 相似文献
118.
Oxidation of Antitubercular Drug Isoniazid by a Lipopathic Oxidant,Cetyltrimethylammonium Dichromate: A Mechanistic Study
下载免费PDF全文
![点击此处可从《国际化学动力学杂志》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The oxidation of an antitubercular drug isoniazid by a lipopathic oxidant cetyltrimethylammonium dichromate (CTADC) in a nonpolar medium generates isonicotinic acid both in the presence and the absence of acetic acid. The conventional UV–vis spectrophotometric method is used to study the reaction kinetics. The occurrence of the Michaelis–Menten–type kinetics with respect to isoniazid confirms the binding of oxidant and substrate to form a complex before the rate‐determining step. The existence of the inverse solvent kinetic isotope effect, k(H2O)/ k(D2O) = 0.7, in an acid‐catalyzed reaction proposes a multistep reaction mechanism. A decrease in the rate constant with an increase in [CTADC] reveals the formation of reverse micellar–type aggregates of CTADC in nonpolar solvents. In the presence of different ionic and nonionic surfactants, CTADC forms mixed aggregates and controls the reaction due to the charge on the interface and also due to partition of oxidant and substrate in two different domains. High negative entropy of activation (ΔS? = –145 and –159 J K?1 mol?1 in the absence and presence of acetic acid) proposes a more ordered and highly solvated transition state than the reactants. Furthermore, the solvent polarity‐reactivity relationship reveals (i) the presence of less polar and less ionic transition state compared to the reactants during the oxidation, (ii) differential contribution from nonpolar and dipolar aprotic solvents toward the reaction process, and (iii) the existence of polarity/hydrophobic switch at log P = 0.73. A suitable mechanism has been proposed on the basis of experimental results. These results may provide insight into the mechanism of isoniazid oxidation in hydrophobic environment and may assist in understanding the drug resistance in different location. 相似文献
119.
120.
A. L. Roes L. B. Tabak L. Shen E. Nieuwlaar M. K. Patel 《Journal of nanoparticle research》2010,12(6):2011-2028
The goal of our study was to investigate the potential benefits of reinforcing polymer matrices with nanoobjects for structural applications by looking at both the mechanical properties and environmental impacts. For determining the mechanical properties, we applied the material indices defined by Ashby for stiffness and strength. For the calculation of environmental impacts, we applied the life cycle assessment methodology, focusing on non-renewable energy use (NREU). NREU has shown to be a good indicator also for other environmental impacts. We then divided the NREU by the appropriate Ashby index to obtain the ‘functionality-based NREU’. We studied 23 different nanocomposites, based on thermoplastic and thermosetting polymer matrices and organophilic montmorillonite, silica, carbon nanotubes (single-walled and multiwalled) and calcium carbonate as filler. For 17 of these, we saw a decrease of the functionality-based NREU with increasing filler content. We draw the conclusion that the use of nanoobjects as filler can have benefits from both an environmental point of view and with respect to mechanical properties. 相似文献